PRVA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRVA_MOUSE
• UniProt AC: P32848
• Protein Name: Parvalbumin alpha
• Gene Name: Pvalb
• Organism: Mus musculus (Mouse).
• Sequence Length: 110
• Protein Description: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions..
• Protein Sequence: MSMTDVLSAEDIKKAIGAFAAADSFDHKKFFQMVGLKKKNPDEVKKVFHILDKDKSGFIEEDELGSILKGFSSDARDLSAKETKTLLAAGDKDGDGKIGVEEFSTLVAES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSMTDVLSA ------CCHHHCCCH	30.32	10036163
2	Phosphorylation	------MSMTDVLSA ------CCHHHCCCH	30.32	22210690
4	Phosphorylation	----MSMTDVLSAED ----CCHHHCCCHHH	18.69	22210690
8	Phosphorylation	MSMTDVLSAEDIKKA CCHHHCCCHHHHHHH	29.47	22817900
14	Ubiquitination	LSAEDIKKAIGAFAA CCHHHHHHHHHHHHH	45.64	22790023
24	Phosphorylation	GAFAAADSFDHKKFF HHHHHCCCCCHHHHH	28.04	28464351
28	Ubiquitination	AADSFDHKKFFQMVG HCCCCCHHHHHHHHC	53.79	22790023
28	Acetylation	AADSFDHKKFFQMVG HCCCCCHHHHHHHHC	53.79	21728379
29	Acetylation	ADSFDHKKFFQMVGL CCCCCHHHHHHHHCC	48.25	21728379
29	Ubiquitination	ADSFDHKKFFQMVGL CCCCCHHHHHHHHCC	48.25	22790023
37	Acetylation	FFQMVGLKKKNPDEV HHHHHCCCCCCHHHH	56.63	21728379
37	Ubiquitination	FFQMVGLKKKNPDEV HHHHHCCCCCCHHHH	56.63	22790023
39	Ubiquitination	QMVGLKKKNPDEVKK HHHCCCCCCHHHHHH	72.61	-
46	Ubiquitination	KNPDEVKKVFHILDK CCHHHHHHHHHHHCC	56.14	22790023
53	Ubiquitination	KVFHILDKDKSGFIE HHHHHHCCCCCCCCC	64.71	22790023
53	Acetylation	KVFHILDKDKSGFIE HHHHHHCCCCCCCCC	64.71	21728379
55	Ubiquitination	FHILDKDKSGFIEED HHHHCCCCCCCCCHH	59.21	22790023
55	Acetylation	FHILDKDKSGFIEED HHHHCCCCCCCCCHH	59.21	21728379
56	Phosphorylation	HILDKDKSGFIEEDE HHHCCCCCCCCCHHH	49.41	22210690
66	Phosphorylation	IEEDELGSILKGFSS CCHHHHHHHHHHCCC	37.05	22210690
69	Ubiquitination	DELGSILKGFSSDAR HHHHHHHHHCCCCHH	57.13	22790023
69	Acetylation	DELGSILKGFSSDAR HHHHHHHHHCCCCHH	57.13	21728379
72	Phosphorylation	GSILKGFSSDARDLS HHHHHHCCCCHHHCC	35.66	22817900
73	Phosphorylation	SILKGFSSDARDLSA HHHHHCCCCHHHCCH	32.78	17203969
79	Phosphorylation	SSDARDLSAKETKTL CCCHHHCCHHHHHHH	41.40	17203969
81	Ubiquitination	DARDLSAKETKTLLA CHHHCCHHHHHHHHH	63.64	22790023
83	Phosphorylation	RDLSAKETKTLLAAG HHCCHHHHHHHHHCC	28.73	17203969
84	Ubiquitination	DLSAKETKTLLAAGD HCCHHHHHHHHHCCC	37.96	22790023
85	Phosphorylation	LSAKETKTLLAAGDK CCHHHHHHHHHCCCC	34.13	22210690
92	Ubiquitination	TLLAAGDKDGDGKIG HHHHCCCCCCCCCCC	63.79	22790023
97	Ubiquitination	GDKDGDGKIGVEEFS CCCCCCCCCCHHHHH	40.81	22790023
105	Phosphorylation	IGVEEFSTLVAES-- CCHHHHHHHHCCC--	30.49	-
110	Phosphorylation	FSTLVAES------- HHHHHCCC-------	35.47	22210690

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRVA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRVA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRVA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRVA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Electrospray ionization mass spectrometry: analysis of the Ca2+-binding properties of human recombinant alpha-parvalbumin and ninemutant proteins.";
Troxler H., Kuster T., Rhyner J.A., Gehrig P., Heizmann C.W.;
Anal. Biochem. 268:64-71(1999).
Cited for: SEQUENCE REVISION TO 110, ACETYLATION AT SER-2, AND MASS SPECTROMETRY.
PubMed: 10036163

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-79 AND THR-83,AND MASS SPECTROMETRY.
PubMed: 17203969