GLU2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLU2B_MOUSE
• UniProt AC: O08795
• Protein Name: Glucosidase 2 subunit beta
• Gene Name: Prkcsh
• Organism: Mus musculus (Mouse).
• Sequence Length: 521
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins..
• Protein Sequence: MLLLLLLLLPLCWAVEVKRPRGVSLSNHHFYEESKPFTCLDGTATIPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGTDEYNSGTVCENTCREKGRKEKESLQQLAEVTREGFRLKKILIEEWKTAREEKQSKLLELQAGKKSLEDQVETLRAAKEEAERPEKEAKDQHRKLWEEQQAAAKARREQERAASAFQELDDNMDGMVSLAELQTHPELDTDGDGALSEEEAQALLSGDTQTDTTSFYDRVWAAIRDKYRSEVPPTDIPVPEETEPKEEKPPVLPPTEEEEEEEEEPEEEEEEEEEEEEAPPPLQPPQPPSPTEDEKMPPYDEETQAIIDAAQEARSKFEEVERSLKEMEESIRSLEQEISFDFGPSGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKHGGSPTSLGTWGSWAGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAACPEPPPEAPSDGDHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	VKRPRGVSLSNHHFY CCCCCCCCCCCCCCC	28.98	27841257
62	Phosphorylation	YCDCKDGSDEPGTAA CCCCCCCCCCCCCCC	49.27	26525534
72	N-linked_Glycosylation	PGTAACPNGSFHCTN CCCCCCCCCCEEECC	59.64	-
89	Phosphorylation	YKPLYILSSRVNDGV CCCEEEEECCCCCCC	13.41	-
103	Phosphorylation	VCDCCDGTDEYNSGT CCCCCCCCCCCCCCC	16.65	26525534
142	Succinylation	REGFRLKKILIEEWK HHCHHHHHHHHHHHH	47.54	23806337
142	Acetylation	REGFRLKKILIEEWK HHCHHHHHHHHHHHH	47.54	23806337
149	Acetylation	KILIEEWKTAREEKQ HHHHHHHHHHHHHHH	35.27	22826441
157	Phosphorylation	TAREEKQSKLLELQA HHHHHHHHHHHHHHH	36.02	28059163
166	Succinylation	LLELQAGKKSLEDQV HHHHHHCCCCHHHHH	42.05	23806337
166	Acetylation	LLELQAGKKSLEDQV HHHHHHCCCCHHHHH	42.05	23806337
166	Succinylation	LLELQAGKKSLEDQV HHHHHHCCCCHHHHH	42.05	-
168	Phosphorylation	ELQAGKKSLEDQVET HHHHCCCCHHHHHHH	40.24	26824392
180 (in isoform 2)	Acetylation	-	55.92	-
180	Acetylation	VETLRAAKEEAERPE HHHHHHHHHHHHCHH	55.92	23201123
196	Acetylation	EAKDQHRKLWEEQQA HHHHHHHHHHHHHHH	56.69	19849947
342	Phosphorylation	LQPPQPPSPTEDEKM CCCCCCCCCCCCCCC	51.65	30635358
344	Phosphorylation	PPQPPSPTEDEKMPP CCCCCCCCCCCCCCC	61.48	30635358
368	Phosphorylation	DAAQEARSKFEEVER HHHHHHHHHHHHHHH	49.06	24719451
376	Phosphorylation	KFEEVERSLKEMEES HHHHHHHHHHHHHHH	30.22	-
383	Phosphorylation	SLKEMEESIRSLEQE HHHHHHHHHHHHHHH	15.25	-
427	Phosphorylation	LCPFKLVSQKPKHGG HCCCCEECCCCCCCC	42.81	-
452	Acetylation	WAGPDHDKFSAMKYE CCCCCCCCCCCCEEE	37.49	22826441
457	Acetylation	HDKFSAMKYEQGTGC CCCCCCCEEECCCCC	45.40	22826441
469	N-linked_Glycosylation	TGCWQGPNRSTTVRL CCCCCCCCCCCCEEE	58.31	-
514	Phosphorylation	EPPPEAPSDGDHDEL CCCCCCCCCCCCCCC	62.36	26525534

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
89	S	Phosphorylation	Kinase	PKC	-	Uniprot
376	S	Phosphorylation	Kinase	PKC	-	Uniprot
383	S	Phosphorylation	Kinase	PKC	-	Uniprot
427	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLU2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLU2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI67_MOUSE	Trim67	physical	22337885
TRIM9_MOUSE	Trim9	physical	22337885
PLPR4_MOUSE	Lppr4	physical	22337885

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.