PLPR4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPR4_MOUSE
• UniProt AC: Q7TME0
• Protein Name: Phospholipid phosphatase-related protein type 4 {ECO:0000250|UniProtKB:Q7Z2D5}
• Gene Name: Plppr4 {ECO:0000312|MGI:MGI:106530}
• Organism: Mus musculus (Mouse).
• Sequence Length: 766
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus (By similarity)..
• Protein Sequence: MQRAGSSGARGECDISGAGRLRLEQAARLGGRTVHTSPGGGLGARQAAGMSAKERPKGKVIKDSVTLLPCFYFVELPILASSVVSLYFLELTDVFKPVHSGFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEPNINAGGCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKENSYIVEDICSGSDLTVINSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSSKLLKPLLVFTFIICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEDSMLQHRDALRSLTDLNQDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKESMVTFSNTLPRANTPSVEDPVRRNASIHASMDSARSKQLLTQWKSKNESRKMSLQVMDTEPEGQSPPRSIEMRSSSEPSRVGVNGDHHVPGNQYLKIQPGTVPGCNNSMPGGPRVSIQSRPGSSQLVHIPEETQENISTSPKSSSARAKWLKAAEKTVACNRSNNQPRIMQVIAMSKQQGVLQSSPKNAEGSTVTCTGSIRYKTLTDHEPSGIVRVEAHPENNRPIIQIPSSTEGEGSGSWKWKAPEKSSLRQTYELNDLNRDSESCESLKDSFGSGDRKRSNIDSNEHHHHGITTIRVTPVEGSEIGSETLSVSSSRDSTLRRKGNIILIPERSNSPENTRNIFYKGTSPTRAYKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MQRAGSSGARGEC --CCCCCCCCCCCCC		22324799
7	Phosphorylation	-MQRAGSSGARGECD -CCCCCCCCCCCCCC		22324799
20	Methylation	CDISGAGRLRLEQAA CCCCCCCCCCHHHHH		18964473
20	Dimethylation	CDISGAGRLRLEQAA CCCCCCCCCCHHHHH		-
33	Phosphorylation	AARLGGRTVHTSPGG HHHHCCCEEECCCCC		22817900
36	Phosphorylation	LGGRTVHTSPGGGLG HCCCEEECCCCCCHH		22324799
37	Phosphorylation	GGRTVHTSPGGGLGA CCCEEECCCCCCHHH		22324799
51	Phosphorylation	ARQAAGMSAKERPKG HHHHCCCCCCCCCCC		-
167	S-palmitoylation	PNINAGGCNFNSFLR CCCCCCCCCHHHHHH		28680068
215	N-linked_Glycosylation	FLTVCKPNYTSLNVS EEEEECCCCEEEEEE		-
218	Phosphorylation	VCKPNYTSLNVSCKE EECCCCEEEEEEECC		14729942
220	N-linked_Glycosylation	KPNYTSLNVSCKENS CCCCEEEEEEECCCE		-
269	N-linked_Glycosylation	VYVSMYFNSTLTDSS HHHHHHHCCCCCCHH		-
347	Phosphorylation	QHRDALRSLTDLNQD HHHHHHHHHHHCCCC		25521595
349	Phosphorylation	RDALRSLTDLNQDPS HHHHHHHHHCCCCHH		20047950
356	Phosphorylation	TDLNQDPSRVLSAKN HHCCCCHHHHHHCCC		-
362	Ubiquitination	PSRVLSAKNGSSGDG HHHHHHCCCCCCCCC		22790023
363	N-linked_Glycosylation	SRVLSAKNGSSGDGI HHHHHCCCCCCCCCC		-
365	Phosphorylation	VLSAKNGSSGDGIAH HHHCCCCCCCCCCCC		29899451
366	Phosphorylation	LSAKNGSSGDGIAHT HHCCCCCCCCCCCCC		29899451
385	Phosphorylation	NRNHRDASSLTNLKR CCCCCCHHHHHCHHH		29899451
386	Phosphorylation	RNHRDASSLTNLKRA CCCCCHHHHHCHHHH		25521595
391	Ubiquitination	ASSLTNLKRANADVE HHHHHCHHHHCCCEE		22790023
401	Phosphorylation	NADVEIITPRSPMGK CCCEEEECCCCCCCC		-
404	Phosphorylation	VEIITPRSPMGKESM EEEECCCCCCCCCCE		25521595
408	Ubiquitination	TPRSPMGKESMVTFS CCCCCCCCCCEEEEC		22790023
410	Phosphorylation	RSPMGKESMVTFSNT CCCCCCCCEEEECCC		26804993
413	Phosphorylation	MGKESMVTFSNTLPR CCCCCEEEECCCCCC		20415495
413	O-linked_Glycosylation	MGKESMVTFSNTLPR CCCCCEEEECCCCCC		55412503
415	Phosphorylation	KESMVTFSNTLPRAN CCCEEEECCCCCCCC		29899451
417	Phosphorylation	SMVTFSNTLPRANTP CEEEECCCCCCCCCC		22324799
433	N-linked_Glycosylation	VEDPVRRNASIHASM CCCCHHHCCCCCCCC		-
435	Phosphorylation	DPVRRNASIHASMDS CCHHHCCCCCCCCCC		19060867
439	Phosphorylation	RNASIHASMDSARSK HCCCCCCCCCCHHHH		22324799
442	Phosphorylation	SIHASMDSARSKQLL CCCCCCCCHHHHHHH		22817900
446	Ubiquitination	SMDSARSKQLLTQWK CCCCHHHHHHHHHHH		27667366
456	N-linked_Glycosylation	LTQWKSKNESRKMSL HHHHHCCCHHHCCEE		-
460	Ubiquitination	KSKNESRKMSLQVMD HCCCHHHCCEEEEEC		22790023
462	Phosphorylation	KNESRKMSLQVMDTE CCHHHCCEEEEECCC		25521595
474	Phosphorylation	DTEPEGQSPPRSIEM CCCCCCCCCCCCEEE		25521595
515	N-linked_Glycosylation	PGTVPGCNNSMPGGP CCCCCCCCCCCCCCC		-
542	Phosphorylation	LVHIPEETQENISTS EEECCHHHHHCCCCC		22817900
545	N-linked_Glycosylation	IPEETQENISTSPKS CCHHHHHCCCCCCCC		-
547	Phosphorylation	EETQENISTSPKSSS HHHHHCCCCCCCCHH		22324799
548	Phosphorylation	ETQENISTSPKSSSA HHHHCCCCCCCCHHH		25521595
549	Phosphorylation	TQENISTSPKSSSAR HHHCCCCCCCCHHHH		25521595
570	N-linked_Glycosylation	AEKTVACNRSNNQPR HHHHHHCCCCCCCCC		-
593	Phosphorylation	KQQGVLQSSPKNAEG HHCCCCCCCCCCCCC		29899451
594	Phosphorylation	QQGVLQSSPKNAEGS HCCCCCCCCCCCCCC		25521595
608	Phosphorylation	STVTCTGSIRYKTLT CEEEECCEEEEEECC		22817900
647	Phosphorylation	SSTEGEGSGSWKWKA CCCCCCCCCCCCCCC		29899451
649	Phosphorylation	TEGEGSGSWKWKAPE CCCCCCCCCCCCCCC		25521595
657	Ubiquitination	WKWKAPEKSSLRQTY CCCCCCCCCCCCEEE		27667366
659	Phosphorylation	WKAPEKSSLRQTYEL CCCCCCCCCCEEEEH		-
673	Phosphorylation	LNDLNRDSESCESLK HHHCCCCCHHHHHHH		29899451
675	Phosphorylation	DLNRDSESCESLKDS HCCCCCHHHHHHHHH		29899451
678	Phosphorylation	RDSESCESLKDSFGS CCCHHHHHHHHHCCC		29899451
682	Phosphorylation	SCESLKDSFGSGDRK HHHHHHHHCCCCCCC		22324799
685	Phosphorylation	SLKDSFGSGDRKRSN HHHHHCCCCCCCCCC		22817900
691	Phosphorylation	GSGDRKRSNIDSNEH CCCCCCCCCCCCCCC		29899451
695	Phosphorylation	RKRSNIDSNEHHHHG CCCCCCCCCCCCCCC		26370283
705	Phosphorylation	HHHHGITTIRVTPVE CCCCCCCEEEEEECC		26370283
718	Phosphorylation	VEGSEIGSETLSVSS CCCCCCCCEEEEEEC		29899451
720	Phosphorylation	GSEIGSETLSVSSSR CCCCCCEEEEEECCC		29899451
722	Phosphorylation	EIGSETLSVSSSRDS CCCCEEEEEECCCCC		29899451
724	Phosphorylation	GSETLSVSSSRDSTL CCEEEEEECCCCCCC		29899451
725	Phosphorylation	SETLSVSSSRDSTLR CEEEEEECCCCCCCC		29899451
726	Phosphorylation	ETLSVSSSRDSTLRR EEEEEECCCCCCCCC		23527152
729	Phosphorylation	SVSSSRDSTLRRKGN EEECCCCCCCCCCCE		29899451
730	Phosphorylation	VSSSRDSTLRRKGNI EECCCCCCCCCCCEE		29899451
744	Phosphorylation	IILIPERSNSPENTR EEEECCCCCCCCCCC		29899451
746	Phosphorylation	LIPERSNSPENTRNI EECCCCCCCCCCCCC		25521595
750	Phosphorylation	RSNSPENTRNIFYKG CCCCCCCCCCCCCCC		22324799

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPR4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPR4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPR4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI67_MOUSE	Trim67	physical	22337885
GLU2B_MOUSE	Prkcsh	physical	22337885

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.