HBB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBB1_MOUSE
• UniProt AC: P02088
• Protein Name: Hemoglobin subunit beta-1
• Gene Name: Hbb-b1
• Organism: Mus musculus (Mouse).
• Sequence Length: 147
• Protein Description: Involved in oxygen transport from the lung to the various peripheral tissues..
• Protein Sequence: MVHLTDAEKAAVSCLWGKVNSDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNAKVKAHGKKVITAFNDGLNHLDSLKGTFASLSELHCDKLHVDPENFRLLGNMIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVHLTDAEK ------CCCCCHHHH	5.21	-
5	Phosphorylation	---MVHLTDAEKAAV ---CCCCCHHHHHHH	20.48	21183079
9	Ubiquitination	VHLTDAEKAAVSCLW CCCCHHHHHHHHHHH	43.28	-
13	Phosphorylation	DAEKAAVSCLWGKVN HHHHHHHHHHHCCCC	9.96	17242355
14	S-nitrosylation	AEKAAVSCLWGKVNS HHHHHHHHHHCCCCC	2.73	24895380
14	S-palmitoylation	AEKAAVSCLWGKVNS HHHHHHHHHHCCCCC	2.73	28526873
18	Succinylation	AVSCLWGKVNSDEVG HHHHHHCCCCCCCCC	27.02	23806337
18	Malonylation	AVSCLWGKVNSDEVG HHHHHHCCCCCCCCC	27.02	26073543
18	Ubiquitination	AVSCLWGKVNSDEVG HHHHHHCCCCCCCCC	27.02	27667366
18	Succinylation	AVSCLWGKVNSDEVG HHHHHHCCCCCCCCC	27.02	-
18	Acetylation	AVSCLWGKVNSDEVG HHHHHHCCCCCCCCC	27.02	21728379
21	Phosphorylation	CLWGKVNSDEVGGEA HHHCCCCCCCCCHHH	37.83	27742792
31	Dimethylation	VGGEALGRLLVVYPW CCHHHHHHHEEEEEC	26.21	-
36	Phosphorylation	LGRLLVVYPWTQRYF HHHHEEEEECCHHHH	5.88	27180971
39	Phosphorylation	LLVVYPWTQRYFDSF HEEEEECCHHHHHCC	9.92	23737553
41	Methylation	VVYPWTQRYFDSFGD EEEECCHHHHHCCCC	27.06	-
42	Phosphorylation	VYPWTQRYFDSFGDL EEECCHHHHHCCCCH	11.26	24925903
45	Phosphorylation	WTQRYFDSFGDLSSA CCHHHHHCCCCHHHH	22.64	24925903
50	Phosphorylation	FDSFGDLSSASAIMG HHCCCCHHHHHHHHC	28.70	24925903
51	Phosphorylation	DSFGDLSSASAIMGN HCCCCHHHHHHHHCC	33.27	24925903
53	Phosphorylation	FGDLSSASAIMGNAK CCCHHHHHHHHCCCE	21.92	25521595
56	Oxidation	LSSASAIMGNAKVKA HHHHHHHHCCCEEEE	3.19	17242355
60	Acetylation	SAIMGNAKVKAHGKK HHHHCCCEEEECCCE	48.55	23806337
60	Succinylation	SAIMGNAKVKAHGKK HHHHCCCEEEECCCE	48.55	-
60	Ubiquitination	SAIMGNAKVKAHGKK HHHHCCCEEEECCCE	48.55	27667366
60	Succinylation	SAIMGNAKVKAHGKK HHHHCCCEEEECCCE	48.55	23806337
62	Acetylation	IMGNAKVKAHGKKVI HHCCCEEEECCCEEE	33.68	7612865
62	Ubiquitination	IMGNAKVKAHGKKVI HHCCCEEEECCCEEE	33.68	-
67	Acetylation	KVKAHGKKVITAFND EEEECCCEEEEECCC	43.38	22733758
67	Ubiquitination	KVKAHGKKVITAFND EEEECCCEEEEECCC	43.38	-
70	Phosphorylation	AHGKKVITAFNDGLN ECCCEEEEECCCCCH	28.34	27180971
81	Phosphorylation	DGLNHLDSLKGTFAS CCCHHHHHHCHHHHH	38.04	25521595
83	Ubiquitination	LNHLDSLKGTFASLS CHHHHHHCHHHHHHH	60.91	-
83	Acetylation	LNHLDSLKGTFASLS CHHHHHHCHHHHHHH	60.91	23954790
83	Malonylation	LNHLDSLKGTFASLS CHHHHHHCHHHHHHH	60.91	26073543
85	Phosphorylation	HLDSLKGTFASLSEL HHHHHCHHHHHHHHH	17.91	22324799
88	Phosphorylation	SLKGTFASLSELHCD HHCHHHHHHHHHCCC	28.39	24925903
90	Phosphorylation	KGTFASLSELHCDKL CHHHHHHHHHCCCCC	35.30	24925903
94	S-palmitoylation	ASLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	28526873
94	S-nitrosylation	ASLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	22178444
94	S-nitrosocysteine	ASLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	-
96	Malonylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	25418362
96	Acetylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	23954790
96	Ubiquitination	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	-
105	Methylation	HVDPENFRLLGNMIV CCCHHHHHHHHHEEE	40.35	-
105	Asymmetric dimethylarginine	HVDPENFRLLGNMIV CCCHHHHHHHHHEEE	40.35	-
121	Ubiquitination	VLGHHLGKDFTPAAQ EECCCCCCCCCHHHH	56.90	-
121	Acetylation	VLGHHLGKDFTPAAQ EECCCCCCCCCHHHH	56.90	156751
124	Phosphorylation	HHLGKDFTPAAQAAF CCCCCCCCHHHHHHH	23.35	27742792
133	Ubiquitination	AAQAAFQKVVAGVAT HHHHHHHHHHHHHHH	32.02	-
133	Acetylation	AAQAAFQKVVAGVAT HHHHHHHHHHHHHHH	32.02	21728379
140	Phosphorylation	KVVAGVATALAHKYH HHHHHHHHHHHHHCC	21.57	19060867
145	Malonylation	VATALAHKYH----- HHHHHHHHCC-----	39.14	26073543
145	Phosphoglycerylation	VATALAHKYH----- HHHHHHHHCC-----	39.14	-
145	Ubiquitination	VATALAHKYH----- HHHHHHHHCC-----	39.14	27667366
145	Acetylation	VATALAHKYH----- HHHHHHHHCC-----	39.14	21728379
146	Phosphorylation	ATALAHKYH------ HHHHHHHCC------	11.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBB1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBB1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HBB1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HBB1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-81, AND MASSSPECTROMETRY.
PubMed: 17242355

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.
PubMed: 15345747