MYCD_MOUSE - dbPTM
MYCD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYCD_MOUSE
UniProt AC Q8VIM5
Protein Name Myocardin
Gene Name Myocd
Organism Mus musculus (Mouse).
Sequence Length 935
Subcellular Localization Nucleus speckle . Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.
Protein Description Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters..
Protein Sequence MTLLGSEHSLLIRRKFRSVLQLRLQQRRTQEQLANQGLIPPLKGPTEFHDPRKQLDSAKTEDSLRRKGRNRSDRASLVTMHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVEKNILPMDSSVKEAIKGTEVSLSKAADAFAFEDDSSRDGLSPDQARSEDPQGSTGSTPDIKSTEAPLDTIQDLTPGSESDKNDAASQPGNQSDPGKQVLGPLSTPIPVHTAVKSKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFLQLQILSQQQQQQQQQQQQQQQQQQQQQRFSYPGMHQTHLKEPNEQMARNPNPSSTPLSNTPLSPVKNSISGQTGVSSLKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALVDRLRPFQDCAGNPVPNFGDITTVTFPVTPNTLPSYQSSPTGFYHFGSTSSSPPISPASSDLSAAGSLPDTFTDASPGFGLHASPVPACTDESLLSSLNGGSGPSEPDGLDSEKDKMLVEKQKVINQLTWKLRQEQRQVEELRMQLQKQKSSCSDQKPLPFLATTIKQEDVSSCPFAPQQASGKGQGHSSDSPPPACETAQLLPHCVESSGQTHVLSSTFLSPQCSPQHSPLGGLKSPQHISLPPSPNNHYFLASSSGAQRENHGVSSPSSSQGCAQMTGLQSSDKVGPTFSIPSPTFSKSSSAVSDITQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKIPKIPGSSCSPTAIPPKPSASFEQASSGGQMAFDHYANDSDEHLEVLLNSHSPIGKVSDVTLLKIGSEEPPFDSIMDGFPGKAAEDLFSAHELLPGPLSPMHAQLSPPSVDSSGLQLSFTESPWETMEWLDLTPPSSTPGFSNLTSSGPSIFNIDFLDVTDLNLNSPMDLHLQQW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationLIRRKFRSVLQLRLQ
HHHHHHHHHHHHHHH		30.2522705319
43AcetylationQGLIPPLKGPTEFHD
CCCCCCCCCCCCCCC		69.4915618493
158PhosphorylationFAFEDDSSRDGLSPD
HCCCCCCCCCCCCHH		41.19-
356PhosphorylationPLSNTPLSPVKNSIS
CCCCCCCCCCCCCCC		28.93-
400PhosphorylationRIRGLPVSGTKTALV
HHCCCCCCCCCCHHH		38.5128059163
454PhosphorylationTGFYHFGSTSSSPPI
CCCCCCCCCCCCCCC		24.9516141410
458PhosphorylationHFGSTSSSPPISPAS
CCCCCCCCCCCCCCC		34.1716141410
462PhosphorylationTSSSPPISPASSDLS
CCCCCCCCCCCCCCH		21.8616141410
466PhosphorylationPPISPASSDLSAAGS
CCCCCCCCCCHHCCC		44.6816141410
527AcetylationKDKMLVEKQKVINQL
HHHHHHHHHHHHHHH		48.197720547
570PhosphorylationKPLPFLATTIKQEDV
CCCCEEEEECCHHHH		31.0726643407
571PhosphorylationPLPFLATTIKQEDVS
CCCEEEEECCHHHHH		22.1426643407
624PhosphorylationGQTHVLSSTFLSPQC
CCEEEEECEEECCCC		21.0116141410
628PhosphorylationVLSSTFLSPQCSPQH
EEECEEECCCCCCCC		14.5616141410
632PhosphorylationTFLSPQCSPQHSPLG
EEECCCCCCCCCCCC		23.5016141410
636PhosphorylationPQCSPQHSPLGGLKS
CCCCCCCCCCCCCCC		19.3016141410
701PhosphorylationGPTFSIPSPTFSKSS
CCCCCCCCCCCCCCC		34.60-
812PhosphorylationEVLLNSHSPIGKVSD
HHHHHCCCCCCCCCE		20.3119776005
859PhosphorylationELLPGPLSPMHAQLS
HCCCCCCCCCCEECC		24.2619776005
866PhosphorylationSPMHAQLSPPSVDSS
CCCCEECCCCCCCCC		23.7619776005
893PhosphorylationTMEWLDLTPPSSTPG
CEEECCCCCCCCCCC		32.5911439182
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
454SPhosphorylationKinaseGSK3BP49841
PSP
454SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
458SPhosphorylationKinaseGSK3BP49841
PSP
458SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
462SPhosphorylationKinaseGSK3BP49841
PSP
462SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
466SPhosphorylationKinaseGSK3BP49841
PSP
466SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
624SPhosphorylationKinaseGSK3BP49841
PSP
624SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
628SPhosphorylationKinaseGSK3BP49841
PSP
628SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
632SPhosphorylationKinaseGSK3BP49841
PSP
632SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
636SPhosphorylationKinaseGSK3BP49841
PSP
636SPhosphorylationKinaseGSK3-BETAQ9WV60
Uniprot
812SPhosphorylationKinaseMAPK-FAMILY-GPS
812SPhosphorylationKinaseMAPK3Q63844
Uniprot
812SPhosphorylationKinaseMAPK1P28482
GPS
812SPhosphorylationKinaseMAPK3P27361
GPS
812SPhosphorylationKinaseMAPK1P63085
Uniprot
859SPhosphorylationKinaseMAPK1P63085
Uniprot
859SPhosphorylationKinaseMAPK1P28482
GPS
859SPhosphorylationKinaseMAPK3P27361
GPS
859SPhosphorylationKinaseMAPK3Q63844
Uniprot
859SPhosphorylationKinaseMAPK-FAMILY-GPS
866SPhosphorylationKinaseMAPK1P63085
Uniprot
866SPhosphorylationKinaseMAPK3P27361
GPS
866SPhosphorylationKinaseMAPK3Q63844
Uniprot
866SPhosphorylationKinaseMAPK-FAMILY-GPS
866SPhosphorylationKinaseMAPK1P28482
GPS
893TPhosphorylationKinaseMAPK1P63085
Uniprot
893TPhosphorylationKinaseMAPK3P27361
GPS
893TPhosphorylationKinaseMAPK1P28482
GPS
893TPhosphorylationKinaseMAPK3Q63844
Uniprot
893TPhosphorylationKinaseMAPK-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYCD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYCD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HIF1N_MOUSEHif1anphysical
20211142
EP300_MOUSEEp300physical
15601857
H2A2A_MOUSEHist2h2aa1physical
15601857
H2B2E_MOUSEHist2h2bephysical
15601857
UBR5_MOUSEUbr5physical
20167605
FBX32_MOUSEFbxo32physical
27403897
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYCD_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphorylation of myocardin by extracellular signal-regulatedkinase.";
Taurin S., Sandbo N., Yau D.M., Sethakorn N., Kach J., Dulin N.O.;
J. Biol. Chem. 284:33789-33794(2009).
Cited for: PHOSPHORYLATION AT SER-812; SER-859; SER-866 AND THR-893, ANDMUTAGENESIS OF SER-812; SER-859; SER-866 AND THR-893.
"Glycogen synthase kinase 3beta inhibits myocardin-dependenttranscription and hypertrophy induction through site-specificphosphorylation.";
Badorff C., Seeger F.H., Zeiher A.M., Dimmeler S.;
Circ. Res. 97:645-654(2005).
Cited for: PHOSPHORYLATION AT SER-454; SER-458; SER-462; SER-466: SER-624;SER-628; SER-632 AND SER-636.

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