MYL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYL1_MOUSE
• UniProt AC: P05977
• Protein Name: Myosin light chain 1/3, skeletal muscle isoform
• Gene Name: Myl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 188
• Protein Description: Regulatory light chain of myosin. Does not bind calcium..
• Protein Sequence: MAPKKDVKKPAAAPAPAPAPAPAPAKPKEEKIDLSAIKIEFSKEQQEDFKEAFLLFDRTGECKITLSQVGDVLRALGTNPTNAEVKKVLGNPSNEEMNAKKIEFEQFLPMMQAISNNKDQGGYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKMKEEEVEALLAGQEDSNGCINYEAFVKHIMSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	25.31	27742792
2 (in isoform 2)	Acetylation	-	25.31	-
2	Methylation	------MAPKKDVKK ------CCCHHHCCC	25.31	-
4 (in isoform 2)	Phosphorylation	-	52.66	27742792
8	Ubiquitination	MAPKKDVKKPAAAPA CCCHHHCCCCCCCCC	64.27	22790023
9	Ubiquitination	APKKDVKKPAAAPAP CCHHHCCCCCCCCCC	39.47	22790023
26	Acetylation	APAPAPAKPKEEKID CCCCCCCCCCHHHCC	56.41	21728379
26	Ubiquitination	APAPAPAKPKEEKID CCCCCCCCCCHHHCC	56.41	22790023
28	Ubiquitination	APAPAKPKEEKIDLS CCCCCCCCHHHCCHH	77.21	22790023
31	Ubiquitination	PAKPKEEKIDLSAIK CCCCCHHHCCHHEEE	42.48	22790023
35	Phosphorylation	KEEKIDLSAIKIEFS CHHHCCHHEEECEEC	24.97	28542873
38	Acetylation	KIDLSAIKIEFSKEQ HCCHHEEECEECHHH	35.58	21728379
38	Ubiquitination	KIDLSAIKIEFSKEQ HCCHHEEECEECHHH	35.58	22790023
43	Ubiquitination	AIKIEFSKEQQEDFK EEECEECHHHHHHHH	65.93	22790023
43	Acetylation	AIKIEFSKEQQEDFK EEECEECHHHHHHHH	65.93	21728379
50	Acetylation	KEQQEDFKEAFLLFD HHHHHHHHHHHHHHC	61.53	21728379
50	Ubiquitination	KEQQEDFKEAFLLFD HHHHHHHHHHHHHHC	61.53	22790023
63	Acetylation	FDRTGECKITLSQVG HCCCCCEEEEHHHHH	34.13	21728379
63	Ubiquitination	FDRTGECKITLSQVG HCCCCCEEEEHHHHH	34.13	22790023
65	Phosphorylation	RTGECKITLSQVGDV CCCCEEEEHHHHHHH	13.07	21454597
67	Phosphorylation	GECKITLSQVGDVLR CCEEEEHHHHHHHHH	17.73	24719451
78	Phosphorylation	DVLRALGTNPTNAEV HHHHHHCCCCCCHHH	38.58	28542873
81	Phosphorylation	RALGTNPTNAEVKKV HHHCCCCCCHHHHHH	49.48	28542873
86	Ubiquitination	NPTNAEVKKVLGNPS CCCCHHHHHHHCCCC	28.77	22790023
86	Acetylation	NPTNAEVKKVLGNPS CCCCHHHHHHHCCCC	28.77	21728379
87	Ubiquitination	PTNAEVKKVLGNPSN CCCHHHHHHHCCCCC	48.11	22790023
93	Phosphorylation	KKVLGNPSNEEMNAK HHHHCCCCCHHHHHH	61.96	28542873
100	Acetylation	SNEEMNAKKIEFEQF CCHHHHHHHHCHHHH	49.64	21728379
100	Ubiquitination	SNEEMNAKKIEFEQF CCHHHHHHHHCHHHH	49.64	22790023
101	Acetylation	NEEMNAKKIEFEQFL CHHHHHHHHCHHHHH	45.09	21728379
101	Ubiquitination	NEEMNAKKIEFEQFL CHHHHHHHHCHHHHH	45.09	22790023
118	Ubiquitination	MQAISNNKDQGGYED HHHHHCCCCCCCCHH	56.53	-
123	Phosphorylation	NNKDQGGYEDFVEGL CCCCCCCCHHHHHEE	21.10	22210690
135	Ubiquitination	EGLRVFDKEGNGTVM HEEEEEEECCCCEEE	56.93	22790023
135	Acetylation	EGLRVFDKEGNGTVM HEEEEEEECCCCEEE	56.93	21728379
152	Phosphorylation	ELRHVLATLGEKMKE HHHHHHHHHHHHHCH	31.00	28542873
156	Ubiquitination	VLATLGEKMKEEEVE HHHHHHHHHCHHHHH	54.17	-
156	Acetylation	VLATLGEKMKEEEVE HHHHHHHHHCHHHHH	54.17	-
158	Ubiquitination	ATLGEKMKEEEVEAL HHHHHHHCHHHHHHH	73.39	-
172	Phosphorylation	LLAGQEDSNGCINYE HHCCCCCCCCCCCHH	34.08	22817900
175	S-nitrosylation	GQEDSNGCINYEAFV CCCCCCCCCCHHHHH	1.82	21278135
175	S-nitrosocysteine	GQEDSNGCINYEAFV CCCCCCCCCCHHHHH	1.82	-
178	Phosphorylation	DSNGCINYEAFVKHI CCCCCCCHHHHHHHH	6.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Trim63	Q38HM4	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.