MYH3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYH3_MOUSE
• UniProt AC: P13541
• Protein Name: Myosin-3
• Gene Name: Myh3
• Organism: Mus musculus (Mouse).
• Sequence Length: 1940
• Subcellular Localization: Cytoplasm, myofibril. Thick filaments of the myofibrils.
• Protein Description: Muscle contraction..
• Protein Sequence: MSSDTEMEVFGIAAPFLRKSEKERIEAQNQPFDAKTYCFVVDSKEEYVKGKIKSSQDGKVTVETEDSRTLVVKPEDVYAMNPPKFDKIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGKAEAHFSLVHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAKLITRTQAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETIAKLTREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYSQLQSKVEDEQTLSLQLQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEATVATLRKKHADSAAELAEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSVESVSKSKANLEKICRTLEDQLSEARGKNEEMQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQIEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAALKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKSIHELEKSRKQMELEKADIQMALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQGALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETIKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLTQLQSEVEDACRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKRNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	QPFDAKTYCFVVDSK CCCCCCEEEEEEECH	5.33	-
51	Acetylation	KEEYVKGKIKSSQDG HHHHHCCEEEECCCC	41.04	6567435
54	Phosphorylation	YVKGKIKSSQDGKVT HHCCEEEECCCCCEE	36.38	-
55	Phosphorylation	VKGKIKSSQDGKVTV HCCEEEECCCCCEEE	27.56	-
59	Acetylation	IKSSQDGKVTVETED EEECCCCCEEEEECC	42.92	6568921
69	Phosphorylation	VETEDSRTLVVKPED EEECCCCEEEECHHH	28.05	22871156
73	Acetylation	DSRTLVVKPEDVYAM CCCEEEECHHHHCCC	34.90	7618823
130	"N6,N6,N6-trimethyllysine"	CVTVNPYKWLPVYNP EEEECCCCCCCCCCH	43.44	-
130	Methylation	CVTVNPYKWLPVYNP EEEECCCCCCCCCCH	43.44	-
174	Phosphorylation	LTDRENQSILITGES ECCCCCCEEEEECCC	30.83	27742792
178	Phosphorylation	ENQSILITGESGAGK CCCEEEEECCCCCCC	31.30	27742792
181	Phosphorylation	SILITGESGAGKTVN EEEEECCCCCCCCCC	34.98	27742792
185	Ubiquitination	TGESGAGKTVNTKRV ECCCCCCCCCCHHHH	49.09	-
195	Phosphorylation	NTKRVIQYFATIAAT CHHHHHHHHHHHHHH	5.53	22807455
236	Phosphorylation	EAFGNAKTVRNDNSS HHHCCCEEECCCCCC	23.45	-
243	Phosphorylation	TVRNDNSSRFGKFIR EECCCCCCCCCEEEE	37.57	26824392
247	Acetylation	DNSSRFGKFIRIHFG CCCCCCCEEEEEEEC	34.60	22826441
255	Phosphorylation	FIRIHFGTTGKLASA EEEEEECCCCCCCCC	31.28	23375375
256	Phosphorylation	IRIHFGTTGKLASAD EEEEECCCCCCCCCC	32.47	28464351
261	Phosphorylation	GTTGKLASADIETYL CCCCCCCCCCHHHHH	36.59	28542873
271	Ubiquitination	IETYLLEKSRVTFQL HHHHHHHCCEEEEEE	43.46	-
275	Phosphorylation	LLEKSRVTFQLKAER HHHCCEEEEEEEEEC	12.45	28464351
279	Ubiquitination	SRVTFQLKAERSYHI CEEEEEEEEECHHHH	37.10	-
354	Phosphorylation	KSGLYKLTGAVMHYG CCCHHHHHHHHHHHC	20.95	28542873
364	Ubiquitination	VMHYGNMKFKQKQRE HHHHCCCCHHHHHHH	54.10	22790023
368	Ubiquitination	GNMKFKQKQREEQAE CCCCHHHHHHHHHCC	52.49	-
379	Phosphorylation	EQAEPDGTEVADKTA HHCCCCCCCHHHHHH	34.37	23375375
406	Ubiquitination	ALCFPRVKVGNEYVT HHHCCCEEECCEEEC	45.78	-
411	Phosphorylation	RVKVGNEYVTKGQTV CEEECCEEECCCCCH	19.88	21183079
413	Phosphorylation	KVGNEYVTKGQTVDQ EECCEEECCCCCHHH	28.67	23737553
429	Phosphorylation	HHAVNALSKSVYEKL HHHHHHHCHHHHHHH	22.07	24899341
450	Phosphorylation	RINQQLDTKLPRQHF HHHHHHCCCCCHHHH	42.97	28542873
503	Ubiquitination	VLEQEEYKKEGIEWT EECHHHHHHCCCCEE	47.86	-
554	Phosphorylation	TSFKNKLYDQHLGKS CHHHHHHHHHCCCCC	18.37	22817900
566	Ubiquitination	GKSNNFQKPKVVKGK CCCCCCCCCCEECCC	42.54	-
599	Ubiquitination	SGWLEKNKDPLNETV ECHHHCCCCCCCCHH	72.32	-
605	Phosphorylation	NKDPLNETVVGLYQK CCCCCCCHHHHHHHH	21.30	28464351
610	Phosphorylation	NETVVGLYQKSSNRL CCHHHHHHHHHHHHH	14.15	28542873
641	Ubiquitination	KKKVAKKKGSSFQTV CEECCCCCCCCHHHH	64.42	-
643	Phosphorylation	KVAKKKGSSFQTVSA ECCCCCCCCHHHHHH	36.54	24899341
644	Phosphorylation	VAKKKGSSFQTVSAL CCCCCCCCHHHHHHH	30.00	24899341
647	Phosphorylation	KKGSSFQTVSALFRE CCCCCHHHHHHHHHH	17.89	28542873
649	Phosphorylation	GSSFQTVSALFRENL CCCHHHHHHHHHHHH	23.73	29899451
665	Phosphorylation	KLMSNLRTTHPHFVR HHHHHHHCCCCCEEE	32.40	24899341
666	Phosphorylation	LMSNLRTTHPHFVRC HHHHHHCCCCCEEEE	27.29	24899341
729	Phosphorylation	RYRVLNASAIPEGQF HHHCCCHHHCCCCCC	26.17	24723360
739	Phosphorylation	PEGQFIDSKKACEKL CCCCCCCCHHHHHHH	31.10	24723360
740	Acetylation	EGQFIDSKKACEKLL CCCCCCCHHHHHHHH	40.41	15608929
740	Ubiquitination	EGQFIDSKKACEKLL CCCCCCCHHHHHHHH	40.41	22790023
741	Ubiquitination	GQFIDSKKACEKLLA CCCCCCHHHHHHHHH	63.32	-
749	Phosphorylation	ACEKLLASIDIDHTQ HHHHHHHHCCCCCCC	22.29	28464351
763	Ubiquitination	QYKFGHTKVFFKAGL CCCCCCCHHHHHHCH	31.22	22790023
767	Ubiquitination	GHTKVFFKAGLLGTL CCCHHHHHHCHHHHH	30.04	-
817	Phosphorylation	ESIFCIQYNIRAFMN HHEEEEEEHHHHHHC	7.82	28464351
842	Ubiquitination	FKIKPLLKSAETEKE HHHHHHHHCHHHHHH	56.13	-
848	Acetylation	LKSAETEKEMATMKE HHCHHHHHHHHHHHH	61.28	7626381
859	Acetylation	TMKEEFQKTKDELAK HHHHHHHHHHHHHHH	63.96	7626393
938	Phosphorylation	EEINAELTAKKRKLE HHHHHHHHHHHHHHH	28.12	28464351
940	Ubiquitination	INAELTAKKRKLEDE HHHHHHHHHHHHHHH	48.12	-
943	Ubiquitination	ELTAKKRKLEDECSE HHHHHHHHHHHHHHH	66.17	-
949	Phosphorylation	RKLEDECSELKKDID HHHHHHHHHHHHCHH	43.87	27742792
952	Acetylation	EDECSELKKDIDDLE HHHHHHHHHCHHHHH	44.33	1910155
952	Ubiquitination	EDECSELKKDIDDLE HHHHHHHHHCHHHHH	44.33	-
953	Ubiquitination	DECSELKKDIDDLEL HHHHHHHHCHHHHHH	72.96	-
961	Phosphorylation	DIDDLELTLAKVEKE CHHHHHHHHHHHHHH	18.46	22210690
964	Ubiquitination	DLELTLAKVEKEKHA HHHHHHHHHHHHHHC	54.78	-
967	Ubiquitination	LTLAKVEKEKHATEN HHHHHHHHHHHCCHH	75.05	-
998	Ubiquitination	AKLTREKKALQEAHQ HHHHHHHHHHHHHHH	49.96	22790023
1007	Phosphorylation	LQEAHQQTLDDLQAE HHHHHHHHHHHHHHH	26.11	28542873
1026	Phosphorylation	NSLSKLKSKLEQQVD HHHHHHHHHHHHHHH	53.56	25777480
1037	Phosphorylation	QQVDDLESSLEQEKK HHHHHHHHHHHHHHH	47.74	25777480
1038	Phosphorylation	QVDDLESSLEQEKKL HHHHHHHHHHHHHHH	26.92	25777480
1055	Ubiquitination	DLERNKRKLEGDLKL HHHHHHHHHHHHHHH	53.12	-
1088	Phosphorylation	LKKKDFEYSQLQSKV HHHHHHCHHHHHHHC	11.17	-
1093	Phosphorylation	FEYSQLQSKVEDEQT HCHHHHHHHCCCHHH	47.46	24899341
1148	Phosphorylation	ARELEELSERLEEAG HHHHHHHHHHHHHCC	24.77	-
1223	Phosphorylation	QKLEKEKSEFKLEID HHHHHHHHCCCEEHH	49.73	23737553
1248	Ubiquitination	KSKANLEKICRTLED HCHHHHHHHHHHHHH	50.72	22790023
1270	Phosphorylation	KNEEMQRSLSELTTQ CCHHHHHHHHHHHHH	21.25	24899341
1272	Phosphorylation	EEMQRSLSELTTQKS HHHHHHHHHHHHHHH	31.63	24899341
1279	Phosphorylation	SELTTQKSRLQTEAG HHHHHHHHHHHHHHH	28.53	24899341
1283	Phosphorylation	TQKSRLQTEAGELSR HHHHHHHHHHHHHHH	32.18	24899341
1305	Phosphorylation	IVSQLSRSKQAFTQQ HHHHHHHHHHHHHHH	26.24	-
1310	Phosphorylation	SRSKQAFTQQIEELK HHHHHHHHHHHHHHH	23.68	28464351
1317	Acetylation	TQQIEELKRQLEEEN HHHHHHHHHHHHHHH	41.18	19863017
1317	Ubiquitination	TQQIEELKRQLEEEN HHHHHHHHHHHHHHH	41.18	22790023
1327	Ubiquitination	LEEENKAKNALAHAL HHHHHHHHHHHHHHH	44.34	-
1336	Phosphorylation	ALAHALQSSRHDCDL HHHHHHHHCHHHHHH	30.14	24899341
1337	Phosphorylation	LAHALQSSRHDCDLL HHHHHHHCHHHHHHH	22.22	27742792
1363	Phosphorylation	AELQRALSKANSEVA HHHHHHHHHHHHHHH	28.83	22817900
1364	Ubiquitination	ELQRALSKANSEVAQ HHHHHHHHHHHHHHH	53.06	-
1367	Phosphorylation	RALSKANSEVAQWRT HHHHHHHHHHHHHHH	38.00	27742792
1374	Phosphorylation	SEVAQWRTKYETDAI HHHHHHHHHHHHHHH	34.71	27742792
1375	Acetylation	EVAQWRTKYETDAIQ HHHHHHHHHHHHHHH	32.30	21728379
1375	Ubiquitination	EVAQWRTKYETDAIQ HHHHHHHHHHHHHHH	32.30	-
1376	Phosphorylation	VAQWRTKYETDAIQR HHHHHHHHHHHHHHH	24.37	23737553
1378	Phosphorylation	QWRTKYETDAIQRTE HHHHHHHHHHHHHHH	27.86	28542873
1384	Phosphorylation	ETDAIQRTEELEEAK HHHHHHHHHHHHHHH	19.89	28464351
1391	Acetylation	TEELEEAKKKLAQRL HHHHHHHHHHHHHHH	54.44	19863027
1391	Ubiquitination	TEELEEAKKKLAQRL HHHHHHHHHHHHHHH	54.44	-
1392	Ubiquitination	EELEEAKKKLAQRLQ HHHHHHHHHHHHHHC	61.13	-
1414	Phosphorylation	AVNAKCASLEKTKQR HHHHHHHCHHHHHHH	46.67	22210690
1417	Ubiquitination	AKCASLEKTKQRLQG HHHHCHHHHHHHHHH	67.33	-
1418	Phosphorylation	KCASLEKTKQRLQGE HHHCHHHHHHHHHHH	24.04	-
1438	Phosphorylation	VDVERANSLAAALDK HCHHHHHHHHHHHHH	20.57	24899341
1452	Ubiquitination	KKQRNFDKVLAEWKT HHHHCHHHHHHHHHH	34.70	22790023
1477	Phosphorylation	AALKESRSLSTELFK HHHHHHHHHHHHHHH	35.63	27742792
1479	Phosphorylation	LKESRSLSTELFKLK HHHHHHHHHHHHHHH	22.53	24899341
1480	Phosphorylation	KESRSLSTELFKLKN HHHHHHHHHHHHHHH	41.84	27742792
1484	Ubiquitination	SLSTELFKLKNAYEE HHHHHHHHHHHHHHH	71.78	-
1567	Phosphorylation	LRIQLELTQVKSEID HHHHHHHHHHHHHHH	23.18	20469934
1571	Phosphorylation	LELTQVKSEIDRKIA HHHHHHHHHHHHHHH	40.71	22210690
1608	Phosphorylation	ALDAEVRSRNEAIRL HHHHHHHCHHHHHHH	44.63	25367039
1654	Phosphorylation	VQGQLKDTQLHLDDA HCCCCCCCCHHHHHH	31.29	28464351
1692	Phosphorylation	EVEELRATLEQTERA HHHHHHHHHHHHHHH	25.13	28542873
1696	Phosphorylation	LRATLEQTERARKLA HHHHHHHHHHHHHHH	20.33	28464351
1733	Phosphorylation	HTKKKLETDLTQLQS HCCHHHHHCHHHHHH	46.90	24719451
1736	Phosphorylation	KKLETDLTQLQSEVE HHHHHCHHHHHHHHH	30.00	24719451
1758	Ubiquitination	NAEEKAKKAITDAAM HHHHHHHHHHHHHHH	50.29	-
1761	Phosphorylation	EKAKKAITDAAMMAE HHHHHHHHHHHHHHH	25.17	28464351
1776	Phosphorylation	ELKKEQDTSAHLERM HHHHHHCCHHHHHHH	27.75	28464351
1777	Phosphorylation	LKKEQDTSAHLERMK HHHHHCCHHHHHHHH	23.21	28464351
1785	Ubiquitination	AHLERMKKNLEQTVK HHHHHHHHHHHHHHH	58.38	-
1792	Ubiquitination	KNLEQTVKDLQHRLD HHHHHHHHHHHHHHH	56.99	27667366
1807	Ubiquitination	EAEQLALKGGKKQIQ HHHHHHHHCCHHHHH	61.07	27667366
1810	Ubiquitination	QLALKGGKKQIQKLE HHHHHCCHHHHHHHH	50.61	-
1811	Ubiquitination	LALKGGKKQIQKLET HHHHCCHHHHHHHHH	56.77	-
1853	Phosphorylation	RRVKELTYQSEEDRK HHHHHHHCCCHHHHC	23.75	-
1916	Phosphorylation	ERADIAESQVNKLRA HHHHHHHHHHHHHHH	30.33	23737553
1920	Ubiquitination	IAESQVNKLRAKTRD HHHHHHHHHHHHHCC	40.26	-
1929	Phosphorylation	RAKTRDFTSSRMVVH HHHHCCCCCCCEEEE	30.04	24899341
1938	Phosphorylation	SRMVVHESEE----- CCEEEECCCC-----	31.95	24899341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYH3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYH3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYH3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLC1_MOUSE	Mlc1	physical	20352047
DNJB1_HUMAN	DNAJB1	physical	26496610
NCBP1_HUMAN	NCBP1	physical	26496610
PRDX1_HUMAN	PRDX1	physical	26496610
RL10_HUMAN	RPL10	physical	26496610
SEM3B_HUMAN	SEMA3B	physical	26496610
MYH13_HUMAN	MYH13	physical	26496610
BAG2_HUMAN	BAG2	physical	26496610
EPN4_HUMAN	CLINT1	physical	26496610
DNJB4_HUMAN	DNAJB4	physical	26496610
PRDX5_HUMAN	PRDX5	physical	26496610
ERGI1_HUMAN	ERGIC1	physical	26496610
K2013_HUMAN	KIAA2013	physical	26496610
LAMA1_HUMAN	LAMA1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.