SEM3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM3B_HUMAN
• UniProt AC: Q13214
• Protein Name: Semaphorin-3B
• Gene Name: SEMA3B
• Organism: Homo sapiens (Human).
• Sequence Length: 749
• Subcellular Localization: Secreted. Endoplasmic reticulum. Accumulates in the endoplasmic reticulum.
• Protein Description: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons..
• Protein Sequence: MGRAGAAAVIPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIAADRVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKRRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWTFQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPLRRLSLHVLSATQAERLARAEEAAPAAPPGPKLWYRDFLQLVEPGGGGSANSLRMCRPQPALQSLPLESRRKGRNRRTHAPEPRAERGPRSATHW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	GLGSAAPSPPRLRLS HCCCCCCCCCCEEEE	42.69	17081983
82	N-linked_Glycosylation	VASLNLDNISKRAKK EEECCHHHHHHHHHH	43.53	UniProtKB CARBOHYD
124	N-linked_Glycosylation	VKLLHAYNRTHLLAC HHHHHHCCCCCEEEC	43.06	UniProtKB CARBOHYD
190	Phosphorylation	EELYSGVAADLMGRD HHHHHCHHHHHCCCC	9.97	-
204	Phosphorylation	DFTIFRSLGQRPSLR CCEEHHCCCCCCCCC	6.21	-
261	Phosphorylation	APALGRLSVSRVGQI CHHHCCCCHHHHHHH	19.38	24719451
268	O-linked_Glycosylation	SVSRVGQICRNDVGG CHHHHHHHHHCCCCC	1.64	-
314	Phosphorylation	LQDVFLLSSRDHRTP HHHEEECCCCCCCCC	26.02	24719451
315	Phosphorylation	QDVFLLSSRDHRTPL HHEEECCCCCCCCCC	41.52	24719451
324 (in isoform 2)	Phosphorylation	-	14.38	20049867
341 (in isoform 2)	Phosphorylation	-	2.97	20049867
427	N-linked_Glycosylation	LFLQVGANYTFTQIA EEEEECCCEEEEHHH	30.37	UniProtKB CARBOHYD
462	Phosphorylation	GTVLKVISVPKGSRP CCEEEEEECCCCCCC	35.04	24719451
490	Phosphorylation	EDSAAVTSMQISSKR CCCCCCEEEEECCCC	11.33	22210691
494	Phosphorylation	AVTSMQISSKRHQLY CCEEEEECCCCCEEE	16.96	22210691
533	Phosphorylation	CCLARDPYCAWDGVA HHCCCCCCCCCCCEE	10.09	24719451
547	Phosphorylation	ACTRFQPSAKRRFRR ECCCCCCCHHHHHHH	35.32	24719451
611	Phosphorylation	TFQRAGVTAHTQVLA EHHHCCCCCHHHHHH	16.29	22210691
611	O-linked_Glycosylation	TFQRAGVTAHTQVLA EHHHCCCCCHHHHHH	16.29	OGP
666	O-linked_Glycosylation	SLHVLSATQAERLAR HHHHHCHHHHHHHHH	25.57	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM3B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SEM3B_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.