MLC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLC1_MOUSE
• UniProt AC: Q8VHK5
• Protein Name: Membrane protein MLC1
• Gene Name: Mlc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 382
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.
• Protein Description: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx..
• Protein Sequence: MTREGQFREELGYDRMPTLERGRQDAGRQDPGSYTPDSKPKDLQLSKRLPPCFSYKTWVFSVLMGSCLLVTSGFSLYLGNVFPSEMDYLRCAAGSCIPSAIVSFAVGRRNVSAIPNFQILFVSTFAVTTTCLIWFGCKLILNPSAININFNLILLLLLELLMAATVIISARSSEEPCKKKKGSISDGSNILDEVTFPARVLKSYSVVEVIAGVSAVLGGVIALNVEEAVSGPHLSVTFFWILVACFPSAIASHVTAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSVMRVVEIFKDYPPAIKSYDVLLLLLLLLLLLQGGLNTGTAIQCVSFKVSARLQAASWDPQSCPQERPAGEVVRGPLKEFDKEKAWRAVVVQMAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LGYDRMPTLERGRQD HCCCCCCCHHHHCCC	31.72	21183079
33	Phosphorylation	AGRQDPGSYTPDSKP CCCCCCCCCCCCCCC	31.08	29899451
35	Phosphorylation	RQDPGSYTPDSKPKD CCCCCCCCCCCCCCC	23.47	25521595
39	Ubiquitination	GSYTPDSKPKDLQLS CCCCCCCCCCCCCHH	64.56	27667366
41	Ubiquitination	YTPDSKPKDLQLSKR CCCCCCCCCCCHHCC	74.86	27667366
47	Ubiquitination	PKDLQLSKRLPPCFS CCCCCHHCCCCCCCC	67.55	27667366
52	S-palmitoylation	LSKRLPPCFSYKTWV HHCCCCCCCCHHHHH	3.14	28680068
63	Ubiquitination	KTWVFSVLMGSCLLV HHHHHHHHHCHHEHH	2.89	27667366
65	Ubiquitination	WVFSVLMGSCLLVTS HHHHHHHCHHEHHCC	15.85	27667366
69	Ubiquitination	VLMGSCLLVTSGFSL HHHCHHEHHCCCCEE	4.66	27667366
71	Ubiquitination	MGSCLLVTSGFSLYL HCHHEHHCCCCEEEC	24.09	27667366
77	Ubiquitination	VTSGFSLYLGNVFPS HCCCCEEECCCCCHH	16.03	27667366
169	Phosphorylation	MAATVIISARSSEEP HHHHHHHHCCCCCCH	13.40	-
181	Ubiquitination	EEPCKKKKGSISDGS CCHHHCCCCCCCCCC	67.76	27667366
183	Phosphorylation	PCKKKKGSISDGSNI HHHCCCCCCCCCCCH	28.00	25521595
185	Phosphorylation	KKKKGSISDGSNILD HCCCCCCCCCCCHHH	37.30	22324799
188	Phosphorylation	KGSISDGSNILDEVT CCCCCCCCCHHHHCC	26.20	25521595
195	Phosphorylation	SNILDEVTFPARVLK CCHHHHCCCCHHHHC	23.12	22324799
205	Ubiquitination	ARVLKSYSVVEVIAG HHHHCCCCHHHHHHC	27.12	27667366
211	Ubiquitination	YSVVEVIAGVSAVLG CCHHHHHHCHHHHHC	19.94	27667366
350	S-palmitoylation	ASWDPQSCPQERPAG CCCCCCCCCCCCCCC	3.21	28680068
365	Ubiquitination	EVVRGPLKEFDKEKA CCCCCCHHHCCHHHH	60.51	27667366
369	Ubiquitination	GPLKEFDKEKAWRAV CCHHHCCHHHHHHHH	67.45	27667366
389	Ubiquitination	Q-------------- C--------------		27667366
393	Ubiquitination	------------------ ------------------		27667366
395	Ubiquitination	-------------------- --------------------		27667366
399	Ubiquitination	------------------------ ------------------------		27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MLC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MLC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MLC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.