KCRM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCRM_MOUSE
• UniProt AC: P07310
• Protein Name: Creatine kinase M-type
• Gene Name: Ckm
• Organism: Mus musculus (Mouse).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
• Protein Sequence: MPFGNTHNKFKLNYKPQEEYPDLSKHNNHMAKVLTPDLYNKLRDKETPSGFTLDDVIQTGVDNPGHPFIMTVGCVAGDEESYTVFKDLFDPIIQDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEQEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNEHLGYVLTCPSNLGTGLRGGVHVKLANLSKHPKFEEILTRLRLQKRGTGGVDTAAVGAVFDISNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MPFGNTHNKFKLN --CCCCCCCCCCCCC	27.49	24899341
9	Acetylation	PFGNTHNKFKLNYKP CCCCCCCCCCCCCCC	35.95	21728379
9	Ubiquitination	PFGNTHNKFKLNYKP CCCCCCCCCCCCCCC	35.95	-
11	Methylation	GNTHNKFKLNYKPQE CCCCCCCCCCCCCHH	37.12	-
11	Acetylation	GNTHNKFKLNYKPQE CCCCCCCCCCCCCHH	37.12	21728379
11	Ubiquitination	GNTHNKFKLNYKPQE CCCCCCCCCCCCCHH	37.12	-
14	Phosphorylation	HNKFKLNYKPQEEYP CCCCCCCCCCHHHCC	34.19	28542873
15	Acetylation	NKFKLNYKPQEEYPD CCCCCCCCCHHHCCC	38.87	21728379
15	Ubiquitination	NKFKLNYKPQEEYPD CCCCCCCCCHHHCCC	38.87	-
20	Phosphorylation	NYKPQEEYPDLSKHN CCCCHHHCCCHHHCC	10.99	28542873
24	Phosphorylation	QEEYPDLSKHNNHMA HHHCCCHHHCCCHHH	38.97	23737553
25	Ubiquitination	EEYPDLSKHNNHMAK HHCCCHHHCCCHHHH	58.61	-
25	Acetylation	EEYPDLSKHNNHMAK HHCCCHHHCCCHHHH	58.61	19862969
30	Sulfoxidation	LSKHNNHMAKVLTPD HHHCCCHHHHHCCHH	4.14	21406390
32	Acetylation	KHNNHMAKVLTPDLY HCCCHHHHHCCHHHH	30.15	21728379
32	Ubiquitination	KHNNHMAKVLTPDLY HCCCHHHHHCCHHHH	30.15	-
35	Phosphorylation	NHMAKVLTPDLYNKL CHHHHHCCHHHHHHH	20.11	23737553
39	Phosphorylation	KVLTPDLYNKLRDKE HHCCHHHHHHHCCCC	20.03	28542873
41	Ubiquitination	LTPDLYNKLRDKETP CCHHHHHHHCCCCCC	31.20	-
41	Acetylation	LTPDLYNKLRDKETP CCHHHHHHHCCCCCC	31.20	21728379
100	Phosphorylation	IQDRHGGYKPTDKHK HCCCCCCCCCCCCCC	20.56	28542873
101	Acetylation	QDRHGGYKPTDKHKT CCCCCCCCCCCCCCC	44.72	21728379
101	Ubiquitination	QDRHGGYKPTDKHKT CCCCCCCCCCCCCCC	44.72	-
103	Phosphorylation	RHGGYKPTDKHKTDL CCCCCCCCCCCCCCC	54.23	28464351
105	Ubiquitination	GGYKPTDKHKTDLNH CCCCCCCCCCCCCCC	49.86	-
107	Ubiquitination	YKPTDKHKTDLNHEN CCCCCCCCCCCCCCC	49.85	-
108	Phosphorylation	KPTDKHKTDLNHENL CCCCCCCCCCCCCCC	45.50	22210690
116	Acetylation	DLNHENLKGGDDLDP CCCCCCCCCCCCCCH	72.87	21728379
116	Ubiquitination	DLNHENLKGGDDLDP CCCCCCCCCCCCCCH	72.87	-
125	Phosphorylation	GDDLDPNYVLSSRVR CCCCCHHHEEECCCC	14.25	24899341
128	Phosphorylation	LDPNYVLSSRVRTGR CCHHHEEECCCCCCC	13.17	23737553
129	Phosphorylation	DPNYVLSSRVRTGRS CHHHEEECCCCCCCC	30.54	24899341
138	Ubiquitination	VRTGRSIKGYTLPPH CCCCCCCCCCCCCCC	47.30	-
140	Phosphorylation	TGRSIKGYTLPPHCS CCCCCCCCCCCCCCC	10.49	28464351
141	Phosphorylation	GRSIKGYTLPPHCSR CCCCCCCCCCCCCCH	41.27	28542873
146	S-nitrosylation	GYTLPPHCSRGERRA CCCCCCCCCHHHHHH	3.51	21278135
146	S-palmitoylation	GYTLPPHCSRGERRA CCCCCCCCCHHHHHH	3.51	26165157
146	S-nitrosocysteine	GYTLPPHCSRGERRA CCCCCCCCCHHHHHH	3.51	-
147	Phosphorylation	YTLPPHCSRGERRAV CCCCCCCCHHHHHHH	40.04	28542873
156	Ubiquitination	GERRAVEKLSVEALN HHHHHHHHHCHHHHH	39.19	-
156	Acetylation	GERRAVEKLSVEALN HHHHHHHHHCHHHHH	39.19	21728379
164	Phosphorylation	LSVEALNSLTGEFKG HCHHHHHHCCCCCCC	28.32	22817900
166	Phosphorylation	VEALNSLTGEFKGKY HHHHHHCCCCCCCEE	34.19	19060867
170	Ubiquitination	NSLTGEFKGKYYPLK HHCCCCCCCEEECCC	50.63	-
170	Acetylation	NSLTGEFKGKYYPLK HHCCCCCCCEEECCC	50.63	21728379
172	Acetylation	LTGEFKGKYYPLKSM CCCCCCCEEECCCCC	42.05	21728379
174	Phosphorylation	GEFKGKYYPLKSMTE CCCCCEEECCCCCCH	12.94	22817900
178	Phosphorylation	GKYYPLKSMTEQEQQ CEEECCCCCCHHHHH	38.32	28464351
180	Phosphorylation	YYPLKSMTEQEQQQL EECCCCCCHHHHHHH	41.42	28464351
196	Ubiquitination	DDHFLFDKPVSPLLL CCCCCCCCCCHHHHH	39.73	-
196	Acetylation	DDHFLFDKPVSPLLL CCCCCCCCCCHHHHH	39.73	21728379
199	Phosphorylation	FLFDKPVSPLLLASG CCCCCCCHHHHHHHC	20.54	26824392
223	Ubiquitination	GIWHNDNKSFLVWVN CCEECCCCCEEEEEC	45.51	-
242	Acetylation	LRVISMEKGGNMKEV EEEEEEECCCCHHHH	64.57	21728379
242	Ubiquitination	LRVISMEKGGNMKEV EEEEEEECCCCHHHH	64.57	-
242	Succinylation	LRVISMEKGGNMKEV EEEEEEECCCCHHHH	64.57	26388266
247	Ubiquitination	MEKGGNMKEVFRRFC EECCCCHHHHHHHHH	55.51	-
254	S-nitrosocysteine	KEVFRRFCVGLQKIE HHHHHHHHHHHHHHH	1.94	-
254	S-nitrosylation	KEVFRRFCVGLQKIE HHHHHHHHHHHHHHH	1.94	21278135
254	S-palmitoylation	KEVFRRFCVGLQKIE HHHHHHHHHHHHHHH	1.94	26165157
259	Ubiquitination	RFCVGLQKIEEIFKK HHHHHHHHHHHHHHH	58.07	-
259	Acetylation	RFCVGLQKIEEIFKK HHHHHHHHHHHHHHH	58.07	21728379
265	Ubiquitination	QKIEEIFKKAGHPFM HHHHHHHHHCCCCCC	47.58	-
265	Acetylation	QKIEEIFKKAGHPFM HHHHHHHHHCCCCCC	47.58	21728379
266	Ubiquitination	KIEEIFKKAGHPFMW HHHHHHHHCCCCCCC	49.18	-
282	Phosphorylation	EHLGYVLTCPSNLGT CCCCEEEECCCCCCC	16.60	-
283	S-nitrosylation	HLGYVLTCPSNLGTG CCCEEEECCCCCCCC	2.80	21278135
283	S-nitrosocysteine	HLGYVLTCPSNLGTG CCCEEEECCCCCCCC	2.80	-
285	Phosphorylation	GYVLTCPSNLGTGLR CEEEECCCCCCCCCC	47.00	28464351
298	Ubiquitination	LRGGVHVKLANLSKH CCCCEEEEECCCCCC	27.31	-
298	Acetylation	LRGGVHVKLANLSKH CCCCEEEEECCCCCC	27.31	21728379
304	Acetylation	VKLANLSKHPKFEEI EEECCCCCCCCHHHH	68.07	21728379
304	Ubiquitination	VKLANLSKHPKFEEI EEECCCCCCCCHHHH	68.07	-
307	Acetylation	ANLSKHPKFEEILTR CCCCCCCCHHHHHHH	66.19	21728379
307	Ubiquitination	ANLSKHPKFEEILTR CCCCCCCCHHHHHHH	66.19	-
313	Phosphorylation	PKFEEILTRLRLQKR CCHHHHHHHHHHHHC	33.06	28464351
322	Phosphorylation	LRLQKRGTGGVDTAA HHHHHCCCCCCCHHH	34.49	23737553
327	Phosphorylation	RGTGGVDTAAVGAVF CCCCCCCHHHHHHEE	17.70	23737553
344	Phosphorylation	SNADRLGSSEVEQVQ CCCCCCCCCCCEEEE	28.11	28542873
345	Phosphorylation	NADRLGSSEVEQVQL CCCCCCCCCCEEEEE	43.81	28542873
365	Acetylation	KLMVEMEKKLEKGQS HHHHHHHHHHHCCCC	62.44	21728379
369	Ubiquitination	EMEKKLEKGQSIDDM HHHHHHHCCCCHHHC	73.09	-
372	Phosphorylation	KKLEKGQSIDDMIPA HHHHCCCCHHHCCCC	36.33	27742792
381	Ubiquitination	DDMIPAQK------- HHCCCCCC-------	65.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Trim63	Q38HM4	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCRM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCRM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KCRM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.