dbPTM

HBB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HBB2_MOUSE
UniProt AC	P02089
Protein Name	Hemoglobin subunit beta-2
Gene Name	Hbb-b2
Organism	Mus musculus (Mouse).
Sequence Length	147
Subcellular Localization
Protein Description	Involved in oxygen transport from the lung to the various peripheral tissues..
Protein Sequence	MVHLTDAEKSAVSCLWAKVNPDEVGGEALGRLLVVYPWTQRYFDSFGDLSSASAIMGNPKVKAHGKKVITAFNEGLKNLDNLKGTFASLSELHCDKLHVDPENFRLLGNAIVIVLGHHLGKDFTPAAQAAFQKVVAGVATALAHKYH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVHLTDAEK ------CCCCCHHHH	5.21	-
5	Phosphorylation	---MVHLTDAEKSAV ---CCCCCHHHHHHH	20.48	21183079
9	Ubiquitination	VHLTDAEKSAVSCLW CCCCHHHHHHHHHHE	45.49	22790023
10	Phosphorylation	HLTDAEKSAVSCLWA CCCHHHHHHHHHHEE	25.96	19060867
13	Phosphorylation	DAEKSAVSCLWAKVN HHHHHHHHHHEEECC	11.83	19060867
14	S-palmitoylation	AEKSAVSCLWAKVNP HHHHHHHHHEEECCH	2.71	28526873
14	S-nitrosylation	AEKSAVSCLWAKVNP HHHHHHHHHEEECCH	2.71	24895380
18	Ubiquitination	AVSCLWAKVNPDEVG HHHHHEEECCHHHCC	30.84	-
18	Acetylation	AVSCLWAKVNPDEVG HHHHHEEECCHHHCC	30.84	21728379
18	Succinylation	AVSCLWAKVNPDEVG HHHHHEEECCHHHCC	30.84	-
18	Malonylation	AVSCLWAKVNPDEVG HHHHHEEECCHHHCC	30.84	26073543
18	Succinylation	AVSCLWAKVNPDEVG HHHHHEEECCHHHCC	30.84	23806337
31	Dimethylation	VGGEALGRLLVVYPW CCHHHHHHHEEEEEC	26.21	-
36	Phosphorylation	LGRLLVVYPWTQRYF HHHHEEEEECCHHHH	5.88	27180971
39	Phosphorylation	LLVVYPWTQRYFDSF HEEEEECCHHHHHCC	9.92	23737553
41	Methylation	VVYPWTQRYFDSFGD EEEECCHHHHHCCCC	27.06	-
42	Phosphorylation	VYPWTQRYFDSFGDL EEECCHHHHHCCCCC	11.26	24925903
45	Phosphorylation	WTQRYFDSFGDLSSA CCHHHHHCCCCCCCH	22.64	24925903
50	Phosphorylation	FDSFGDLSSASAIMG HHCCCCCCCHHHHCC	28.70	24925903
51	Phosphorylation	DSFGDLSSASAIMGN HCCCCCCCHHHHCCC	33.27	24925903
53	Phosphorylation	FGDLSSASAIMGNPK CCCCCCHHHHCCCCC	21.92	24925903
56	Oxidation	LSSASAIMGNPKVKA CCCHHHHCCCCCHHC	4.19	17242355
60	Ubiquitination	SAIMGNPKVKAHGKK HHHCCCCCHHCCCCC	61.44	-
60	Acetylation	SAIMGNPKVKAHGKK HHHCCCCCHHCCCCC	61.44	23806337
60	Succinylation	SAIMGNPKVKAHGKK HHHCCCCCHHCCCCC	61.44	23806337
60	Succinylation	SAIMGNPKVKAHGKK HHHCCCCCHHCCCCC	61.44	-
67	Ubiquitination	KVKAHGKKVITAFNE CHHCCCCCHHHHHHH	43.38	22790023
67	Phosphoglycerylation	KVKAHGKKVITAFNE CHHCCCCCHHHHHHH	43.38	-
77	Acetylation	TAFNEGLKNLDNLKG HHHHHHHHCHHHHCC	67.34	7617255
77	Ubiquitination	TAFNEGLKNLDNLKG HHHHHHHHCHHHHCC	67.34	22790023
83	Acetylation	LKNLDNLKGTFASLS HHCHHHHCCHHHHHH	63.26	7753599
83	Malonylation	LKNLDNLKGTFASLS HHCHHHHCCHHHHHH	63.26	26073543
83	Ubiquitination	LKNLDNLKGTFASLS HHCHHHHCCHHHHHH	63.26	-
83	Phosphoglycerylation	LKNLDNLKGTFASLS HHCHHHHCCHHHHHH	63.26	-
85	Phosphorylation	NLDNLKGTFASLSEL CHHHHCCHHHHHHHH	17.91	22324799
88	Phosphorylation	NLKGTFASLSELHCD HHCCHHHHHHHHCCC	28.39	24925903
90	Phosphorylation	KGTFASLSELHCDKL CCHHHHHHHHCCCCC	35.30	24925903
94	S-nitrosocysteine	ASLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	-
96	Acetylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	160873
96	Ubiquitination	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	22790023
105	Methylation	HVDPENFRLLGNAIV CCCHHHHHHHHCEEE	40.35	24129315
105	Asymmetric dimethylarginine	HVDPENFRLLGNAIV CCCHHHHHHHHCEEE	40.35	-
121	Ubiquitination	VLGHHLGKDFTPAAQ EECCCCCCCCCHHHH	56.90	-
121	Acetylation	VLGHHLGKDFTPAAQ EECCCCCCCCCHHHH	56.90	7669929
124	Phosphorylation	HHLGKDFTPAAQAAF CCCCCCCCHHHHHHH	23.35	27742792
133	Ubiquitination	AAQAAFQKVVAGVAT HHHHHHHHHHHHHHH	32.02	-
133	Acetylation	AAQAAFQKVVAGVAT HHHHHHHHHHHHHHH	32.02	7684881
140	Phosphorylation	KVVAGVATALAHKYH HHHHHHHHHHHHHCC	21.57	19060867
145	Ubiquitination	VATALAHKYH----- HHHHHHHHCC-----	39.14	-
145	Acetylation	VATALAHKYH----- HHHHHHHHCC-----	39.14	109327
145	Malonylation	VATALAHKYH----- HHHHHHHHCC-----	39.14	26073543
146	Phosphorylation	ATALAHKYH------ HHHHHHHCC------	11.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HBB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HBB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HBB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HBB2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HBB2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-42 AND SER-45, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-36, AND MASSSPECTROMETRY.	18034455 [Abstract]