SIG12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIG12_MOUSE
• UniProt AC: Q91Y57
• Protein Name: Sialic acid-binding Ig-like lectin 12
• Gene Name: Siglec12
• Organism: Mus musculus (Mouse).
• Sequence Length: 467
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules..
• Protein Sequence: MLLLLLLLLLWGIKGVEGQNPQEVFTLNVERKVVVQEGLCVLVPCNFSYLKKRLTDWTDSDPVHGFWYREGTDRRKDSIVATNNPIRKAVKETRNRFFLLGDPWRNDCSLNIREIRKKDAGLYFFRLERGKTKYNYMWDKMTLVVTALTNTPQILLPETLEAGHPSNLTCSVPWDCGWTAPPIFSWTGTSVSFLSTNTTGSSVLTITPQPQDHGTNLTCQVTLPGTNVSTRMTIRLNVSYAPKNLTVTIYQGADSVSTILKNGSSLPISEGQSLRLICSTDSYPPANLSWSWDNLTLCPSKLSKPGLLELFPVHLKHGGVYTCQAQHALGSQHISLSLSPQSSATLSEMMMGTFVGSGVTALLFLSVCILLLAVRSYRRKPARPAVVAPHPDALKVSVSQNPLVESQADDSSEPLPSILEAAPSSTEEEIHYATLSFHEMKPMNLWGQQDTTTEYSEIKFPQRTAWP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	LCVLVPCNFSYLKKR EEEEEECCHHHHHHH	23.87	-
167	N-linked_Glycosylation	LEAGHPSNLTCSVPW HHCCCCCCCEEECCC	43.77	-
197	N-linked_Glycosylation	SVSFLSTNTTGSSVL EEEEEECCCCCCCEE	32.06	-
216	N-linked_Glycosylation	QPQDHGTNLTCQVTL CCCCCCCCEEEEEEC	37.63	-
227	N-linked_Glycosylation	QVTLPGTNVSTRMTI EEECCCCCCCCCEEE	31.49	-
237	N-linked_Glycosylation	TRMTIRLNVSYAPKN CCEEEEEEEEECCCC	15.73	-
244	N-linked_Glycosylation	NVSYAPKNLTVTIYQ EEEECCCCEEEEEEE	39.63	-
262	N-linked_Glycosylation	SVSTILKNGSSLPIS CHHHHHHCCCCCCCC	52.73	-
287	N-linked_Glycosylation	TDSYPPANLSWSWDN CCCCCCCCCEECCCC	40.14	-
294	N-linked_Glycosylation	NLSWSWDNLTLCPSK CCEECCCCCEECHHH	28.77	-
339	Phosphorylation	QHISLSLSPQSSATL CEEEEEECCCCCCCH	19.95	-
432	Phosphorylation	STEEEIHYATLSFHE CCHHHHEEEEEECCC	13.62	11171044
451	Phosphorylation	NLWGQQDTTTEYSEI CCCCCCCCCCCHHHC	31.14	29472430
452	Phosphorylation	LWGQQDTTTEYSEIK CCCCCCCCCCHHHCC	26.39	29472430
453	Phosphorylation	WGQQDTTTEYSEIKF CCCCCCCCCHHHCCC	34.71	29472430
455	Phosphorylation	QQDTTTEYSEIKFPQ CCCCCCCHHHCCCCC	14.98	11171044
456	Phosphorylation	QDTTTEYSEIKFPQR CCCCCCHHHCCCCCC	26.98	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIG12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIG12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIG12_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SIG12_MOUSE	Siglece	physical	11171044
LG3BP_MOUSE	Lgals3bp	physical	25320078

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.