MSI1H_HUMAN - dbPTM
MSI1H_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSI1H_HUMAN
UniProt AC O43347
Protein Name RNA-binding protein Musashi homolog 1
Gene Name MSI1
Organism Homo sapiens (Human).
Sequence Length 362
Subcellular Localization Cytoplasm. Nucleus.
Protein Description RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity)..
Protein Sequence METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLPSAPVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHSLGGPLIATAFTNGYH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------METDAPQP
-------CCCCCCCC		12.9621406692
3Phosphorylation-----METDAPQPGL
-----CCCCCCCCCC		35.8424173317
6Ubiquitination--METDAPQPGLASP
--CCCCCCCCCCCCC		43.6522817900
12PhosphorylationAPQPGLASPDSPHDP
CCCCCCCCCCCCCCC		33.9922617229
15PhosphorylationPGLASPDSPHDPCKM
CCCCCCCCCCCCHHH		27.7627050516
28PhosphorylationKMFIGGLSWQTTQEG
HHHHCCCCHHCCHHH		22.0327050516
41UbiquitinationEGLREYFGQFGEVKE
HHHHHHHCCCCCEEE		22.4723000965
44UbiquitinationREYFGQFGEVKECLV
HHHHCCCCCEEEEEE		30.7923000965
47UbiquitinationFGQFGEVKECLVMRD
HCCCCCEEEEEEECC		38.1132015554
58UbiquitinationVMRDPLTKRSRGFGF
EECCCCCCCCCCCCC		56.94-
76UbiquitinationMDQAGVDKVLAQSRH
CCHHCHHHHHHHCHH		36.4221890473
81PhosphorylationVDKVLAQSRHELDSK
HHHHHHHCHHHHCCC		29.9628188228
93UbiquitinationDSKTIDPKVAFPRRA
CCCCCCHHHCCCCCC		42.31-
103UbiquitinationFPRRAQPKMVTRTKK
CCCCCCCCCEECCEE		33.6427667366
144UbiquitinationDAMLMFDKTTNRHRG
CEEEEEECCCCCCCC		46.0823000965
145PhosphorylationAMLMFDKTTNRHRGF
EEEEEECCCCCCCCE		31.0220068231
191PhosphorylationAQPKEVMSPTGSARG
CCCCCCCCCCCCCCC		25.2029255136
193O-linked_GlycosylationPKEVMSPTGSARGRS
CCCCCCCCCCCCCCC		36.1429237092
193PhosphorylationPKEVMSPTGSARGRS
CCCCCCCCCCCCCCC		36.1429255136
195O-linked_GlycosylationEVMSPTGSARGRSRV
CCCCCCCCCCCCCCC		19.7829237092
195PhosphorylationEVMSPTGSARGRSRV
CCCCCCCCCCCCCCC		19.7829255136
197MethylationMSPTGSARGRSRVMP
CCCCCCCCCCCCCCC		42.6316187475
199MethylationPTGSARGRSRVMPYG
CCCCCCCCCCCCCCC		18.7554557433
201MethylationGSARGRSRVMPYGMD
CCCCCCCCCCCCCHH		27.65115484083
251PhosphorylationPEFRVERTPLPSAPV
CCCEEEECCCCCCCC		18.70-
255PhosphorylationVERTPLPSAPVLPEL
EEECCCCCCCCCCCC		53.54-
299PhosphorylationTMAPPPGSTPSRTGG
CCCCCCCCCCCCCCC		42.8132142685
300PhosphorylationMAPPPGSTPSRTGGF
CCCCCCCCCCCCCCC		31.0624719451
302PhosphorylationPPPGSTPSRTGGFLG
CCCCCCCCCCCCCCC		42.4327732954
310PhosphorylationRTGGFLGTTSPGPMA
CCCCCCCCCCCCHHH		26.6727732954
311PhosphorylationTGGFLGTTSPGPMAE
CCCCCCCCCCCHHHH		31.0027732954
312PhosphorylationGGFLGTTSPGPMAEL
CCCCCCCCCCHHHHH		27.9127732954
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSI1H_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSI1H_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSI1H_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
AGO2_HUMANAGO2physical
24778252
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSI1H_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-12 AND SER-191, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-12 AND SER-191, AND MASS SPECTROMETRY.

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