GMFB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMFB_HUMAN
• UniProt AC: P60983
• Protein Name: Glia maturation factor beta
• Gene Name: GMFB
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Protein Description: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells..
• Protein Sequence: MSESLVVCDVAEDLVEKLRKFRFRKETNNAAIIMKIDKDKRLVVLDEELEGISPDELKDELPERQPRFIVYSYKYQHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNKLVQTAELTKVFEIRNTEDLTEEWLREKLGFFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSESLVVCD ------CCCCEEEEE	35.57	29514088
2	Acetylation	------MSESLVVCD ------CCCCEEEEE	35.57	19413330
4	Phosphorylation	----MSESLVVCDVA ----CCCCEEEEECH	21.11	29514088
17	Ubiquitination	VAEDLVEKLRKFRFR CHHHHHHHHHHHCCC	46.22	24816145
25	Ubiquitination	LRKFRFRKETNNAAI HHHHCCCCCCCCEEE	67.20	33845483
27	Phosphorylation	KFRFRKETNNAAIIM HHCCCCCCCCEEEEE	36.49	9030586
35	Ubiquitination	NNAAIIMKIDKDKRL CCEEEEEEECCCCCE	37.03	22817900
35	Ubiquitination	NNAAIIMKIDKDKRL CCEEEEEEECCCCCE	37.03	21890473
35	Ubiquitination	NNAAIIMKIDKDKRL CCEEEEEEECCCCCE	37.03	21890473
38	Ubiquitination	AIIMKIDKDKRLVVL EEEEEECCCCCEEEE	69.49	22817900
40	Ubiquitination	IMKIDKDKRLVVLDE EEEECCCCCEEEECH	54.06	22817900
53	Phosphorylation	DEELEGISPDELKDE CHHHCCCCHHHHHHH	36.84	9030586
58	Ubiquitination	GISPDELKDELPERQ CCCHHHHHHHCCCCC	47.30	21906983
58	Ubiquitination	GISPDELKDELPERQ CCCHHHHHHHCCCCC	47.30	21890473
72	Phosphorylation	QPRFIVYSYKYQHDD CCCEEEEEEEEECCC	12.31	9030586
74	Ubiquitination	RFIVYSYKYQHDDGR CEEEEEEEEECCCCC	32.28	21890473
74	Ubiquitination	RFIVYSYKYQHDDGR CEEEEEEEEECCCCC	32.28	21890473
74	Acetylation	RFIVYSYKYQHDDGR CEEEEEEEEECCCCC	32.28	25953088
74	Ubiquitination	RFIVYSYKYQHDDGR CEEEEEEEEECCCCC	32.28	21906983
83	Phosphorylation	QHDDGRVSYPLCFIF ECCCCCEEEEEEEEE	21.48	9030586
84	Phosphorylation	HDDGRVSYPLCFIFS CCCCCEEEEEEEEEC	9.43	21082442
97	Ubiquitination	FSSPVGCKPEQQMMY ECCCCCCCHHHHHCC	45.73	-
110	Acetylation	MYAGSKNKLVQTAEL CCCCCCCCEEEEHHH	54.49	25953088
110	Ubiquitination	MYAGSKNKLVQTAEL CCCCCCCCEEEEHHH	54.49	33845483
119	Ubiquitination	VQTAELTKVFEIRNT EEEHHHEEEEEECCC	58.51	-
119	Ubiquitination	VQTAELTKVFEIRNT EEEHHHEEEEEECCC	58.51	23000965
119	Acetylation	VQTAELTKVFEIRNT EEEHHHEEEEEECCC	58.51	24620447
137	2-Hydroxyisobutyrylation	TEEWLREKLGFFH-- CHHHHHHHHCCCC--	47.69	-
137	Ubiquitination	TEEWLREKLGFFH-- CHHHHHHHHCCCC--	47.69	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
27	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
27	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
27	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
27	T	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS
27	T	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
27	T	Phosphorylation	Kinase	RSK_GROUP	-	PhosphoELM
53	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
72	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
83	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
83	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
83	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMFB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMFB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK03_HUMAN	MAPK3	physical	8639570
HNRH2_HUMAN	HNRNPH2	physical	26344197
PFD6_HUMAN	PFDN6	physical	26344197
SETD3_HUMAN	SETD3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-84, AND MASSSPECTROMETRY.
PubMed: 15592455