NACC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NACC1_HUMAN
• UniProt AC: Q96RE7
• Protein Name: Nucleus accumbens-associated protein 1
• Gene Name: NACC1
• Organism: Homo sapiens (Human).
• Sequence Length: 527
• Subcellular Localization: Nucleus. Cytoplasm. Distribution in the cytoplasm is dependent on phosphorylation..
• Protein Description: Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines..
• Protein Sequence: MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNNSRSAVVELPAAVQPQSFQQILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQGLHAEEAPSSEPQSPVAQTSGWPACSTPLPLVSRVKTEQQESDSVQCMPVAKRLWDSGQKEAGGGGNGSRKMAKFSTPDLAANRPHQPPPPQQAPVVAAAQPAVAAGAGQPAGGVAAAGGVVSGPSTSERTSPGTSSAYTSDSPGSYHNEEDEEEDGGEEGMDEQYRQICNMYTMYSMMNVGQTAEKVEALPEQVAPESRNRIRVRQDLASLPAELINQIGNRCHPKLYDEGDPSEKLELVTGTNVYITRAQLMNCHVSAGTRHKVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMNAIAADMCTNARRVVRKSWMPKVKVLKAEDDAYTTFISETGKIEPDMMGVEHGFETASHEGEAGPSAEALQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAQTLQMEIPN ----CCCEEEEECCC	14.93	24043423
15	Phosphorylation	EIPNFGNSILECLNE ECCCHHHHHHHHHHH	29.00	24043423
29	Phosphorylation	EQRLQGLYCDVSVVV HHHHCCCCCCEEEEE	8.07	24043423
33	Phosphorylation	QGLYCDVSVVVKGHA CCCCCCEEEEEECCH	8.92	24043423
54	Phosphorylation	VLAASSSYFRDLFNN HHHHCCHHHHHHHCC	12.46	24719451
124	Phosphorylation	TEFFLKVSSPSCDSQ CCEEEEECCCCCCCC	34.64	23927012
125	Phosphorylation	EFFLKVSSPSCDSQG CEEEEECCCCCCCCC	24.66	23927012
127	Phosphorylation	FLKVSSPSCDSQGLH EEEECCCCCCCCCCC	32.29	23927012
130	Phosphorylation	VSSPSCDSQGLHAEE ECCCCCCCCCCCCCC	30.40	23927012
140	Phosphorylation	LHAEEAPSSEPQSPV CCCCCCCCCCCCCCC	55.15	23927012
141	Phosphorylation	HAEEAPSSEPQSPVA CCCCCCCCCCCCCCC	52.84	23927012
145	Phosphorylation	APSSEPQSPVAQTSG CCCCCCCCCCCCCCC	31.86	23927012
150	Phosphorylation	PQSPVAQTSGWPACS CCCCCCCCCCCCCCC	21.33	23927012
151	Phosphorylation	QSPVAQTSGWPACST CCCCCCCCCCCCCCC	27.12	23927012
157	Phosphorylation	TSGWPACSTPLPLVS CCCCCCCCCCCCCEE	34.86	30576142
158	Phosphorylation	SGWPACSTPLPLVSR CCCCCCCCCCCCEEC	28.82	20873877
164	Phosphorylation	STPLPLVSRVKTEQQ CCCCCCEECCCCCCC	38.75	20873877
167	Acetylation	LPLVSRVKTEQQESD CCCEECCCCCCCCCC	45.28	26051181
167	Sumoylation	LPLVSRVKTEQQESD CCCEECCCCCCCCCC	45.28	-
167	Ubiquitination	LPLVSRVKTEQQESD CCCEECCCCCCCCCC	45.28	-
167	Sumoylation	LPLVSRVKTEQQESD CCCEECCCCCCCCCC	45.28	25114211
168	Phosphorylation	PLVSRVKTEQQESDS CCEECCCCCCCCCCC	35.85	26074081
173	Phosphorylation	VKTEQQESDSVQCMP CCCCCCCCCCCCHHH	30.74	26074081
175	Phosphorylation	TEQQESDSVQCMPVA CCCCCCCCCCHHHHH	24.30	26074081
179	Sulfoxidation	ESDSVQCMPVAKRLW CCCCCCHHHHHHHHH	1.35	21406390
183	Ubiquitination	VQCMPVAKRLWDSGQ CCHHHHHHHHHHCCC	48.54	-
183	Acetylation	VQCMPVAKRLWDSGQ CCHHHHHHHHHHCCC	48.54	25953088
183	Sumoylation	VQCMPVAKRLWDSGQ CCHHHHHHHHHHCCC	48.54	28112733
188	Phosphorylation	VAKRLWDSGQKEAGG HHHHHHHCCCCCCCC	31.38	25159151
191	Ubiquitination	RLWDSGQKEAGGGGN HHHHCCCCCCCCCCC	53.72	-
202	Acetylation	GGGNGSRKMAKFSTP CCCCCCCCCCCCCCC	44.93	7266955
205	Acetylation	NGSRKMAKFSTPDLA CCCCCCCCCCCCCHH	36.03	7266967
259	Phosphorylation	VVSGPSTSERTSPGT EEECCCCCCCCCCCC	29.44	-
262	Phosphorylation	GPSTSERTSPGTSSA CCCCCCCCCCCCCCC	34.91	28450419
263	Phosphorylation	PSTSERTSPGTSSAY CCCCCCCCCCCCCCC	27.79	28450419
266	Phosphorylation	SERTSPGTSSAYTSD CCCCCCCCCCCCCCC	23.92	28450419
267	Phosphorylation	ERTSPGTSSAYTSDS CCCCCCCCCCCCCCC	20.91	23186163
268	Phosphorylation	RTSPGTSSAYTSDSP CCCCCCCCCCCCCCC	25.73	30576142
270	Phosphorylation	SPGTSSAYTSDSPGS CCCCCCCCCCCCCCC	14.55	30576142
271	Phosphorylation	PGTSSAYTSDSPGSY CCCCCCCCCCCCCCC	26.27	28450419
272	Phosphorylation	GTSSAYTSDSPGSYH CCCCCCCCCCCCCCC	24.34	30576142
274	Phosphorylation	SSAYTSDSPGSYHNE CCCCCCCCCCCCCCC	30.81	24043423
277	Phosphorylation	YTSDSPGSYHNEEDE CCCCCCCCCCCCCCC	26.97	24043423
278	Phosphorylation	TSDSPGSYHNEEDEE CCCCCCCCCCCCCCC	17.99	30576142
297	Phosphorylation	EEGMDEQYRQICNMY CCCCHHHHHHHHHHH	11.48	23186163
305	Phosphorylation	RQICNMYTMYSMMNV HHHHHHHHHHHCCCC	10.00	27642862
307	Phosphorylation	ICNMYTMYSMMNVGQ HHHHHHHHHCCCCCC	5.89	27642862
318	Sumoylation	NVGQTAEKVEALPEQ CCCCHHHHHHHCHHH	42.80	28112733
330	Phosphorylation	PEQVAPESRNRIRVR HHHHCCHHHHHHCHH	33.52	21815630
368	Ubiquitination	DEGDPSEKLELVTGT CCCCHHHHEEEEECC	52.15	21906983
411	Phosphorylation	ASFFDRNTLANSCGT HHHCCCCHHHHHCCC	28.30	-
415	Phosphorylation	DRNTLANSCGTGIRS CCCHHHHHCCCCCCC	14.33	28555341
418	Phosphorylation	TLANSCGTGIRSSTN HHHHHCCCCCCCCCC	33.49	28555341
422	Phosphorylation	SCGTGIRSSTNDPRR HCCCCCCCCCCCCCC	39.32	27251275
423	Phosphorylation	CGTGIRSSTNDPRRK CCCCCCCCCCCCCCC	22.75	27251275
424	Phosphorylation	GTGIRSSTNDPRRKP CCCCCCCCCCCCCCC	44.91	27251275
452	Ubiquitination	QNFAPNFKESEMNAI HHCCCCCCHHHHHHH	67.95	-
452	Sumoylation	QNFAPNFKESEMNAI HHCCCCCCHHHHHHH	67.95	28112733
474	Phosphorylation	ARRVVRKSWMPKVKV HHHHHHHHHCCCEEE	20.31	24719451
480	Sumoylation	KSWMPKVKVLKAEDD HHHCCCEEEEEECCC	48.23	28112733
483	Sumoylation	MPKVKVLKAEDDAYT CCCEEEEEECCCCCE	53.36	28112733
483	Ubiquitination	MPKVKVLKAEDDAYT CCCEEEEEECCCCCE	53.36	21906983
483	Sumoylation	MPKVKVLKAEDDAYT CCCEEEEEECCCCCE	53.36	-
489	Phosphorylation	LKAEDDAYTTFISET EEECCCCCEEEEECC	17.20	28796482
490	Phosphorylation	KAEDDAYTTFISETG EECCCCCEEEEECCC	19.56	29978859
491	Phosphorylation	AEDDAYTTFISETGK ECCCCCEEEEECCCC	13.29	28555341
498	Ubiquitination	TFISETGKIEPDMMG EEEECCCCCCCCCCC	51.85	21906983
498	Sumoylation	TFISETGKIEPDMMG EEEECCCCCCCCCCC	51.85	28112733
512	Phosphorylation	GVEHGFETASHEGEA CCCCCCCCCCCCCCC	31.06	22210691
514	Phosphorylation	EHGFETASHEGEAGP CCCCCCCCCCCCCCC	29.50	22210691
522	Phosphorylation	HEGEAGPSAEALQ-- CCCCCCCCHHHCC--	37.51	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
259	S	Phosphorylation	Kinase	PKC	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NACC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NACC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	17699672
PSMD7_HUMAN	PSMD7	physical	17699672
CUL4A_HUMAN	CUL4A	physical	17699672
NACC1_HUMAN	NACC1	physical	17130457
ZBTB6_HUMAN	ZBTB6	physical	19121354
BCL6_HUMAN	BCL6	physical	19121354
ZBT14_HUMAN	ZBTB14	physical	19121354
BCOR_HUMAN	BCOR	physical	19121354
KLHL2_HUMAN	KLHL2	physical	19121354
ENC1_HUMAN	ENC1	physical	19121354
NACC1_HUMAN	NACC1	physical	19407373
HDAC3_HUMAN	HDAC3	physical	16033423
HDAC4_HUMAN	HDAC4	physical	16033423
TADBP_HUMAN	TARDBP	physical	23022214
PRKN_HUMAN	PARK2	physical	24231739

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.