SYCP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYCP3_HUMAN
• UniProt AC: Q8IZU3
• Protein Name: Synaptonemal complex protein 3
• Gene Name: SYCP3
• Organism: Homo sapiens (Human).
• Sequence Length: 236
• Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere . It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes an
• Protein Description: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity). Required for normal meiosis during spermatogenesis and male fertility. [PubMed: 14643120 Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity]
• Protein Sequence: MVSSGKKYSRKSGKPSVEDQFTRAYDFETEDKKDLSGSEEDVIEGKTAVIEKRRKKRSSAGVVEDMGGEVQNMLEGVGVDINKALLAKRKRLEMYTKASLKTSNQKIEHVWKTQQDQRQKLNQEYSQQFLTLFQQWDLDMQKAEEQEEKILNMFRQQQKILQQSRIVQSQRLKTIKQLYEQFIKSMEELEKNHDNLLTGAQNEFKKEMAMLQKKIMMETQQQEIASVRKSLQSMLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MVSSGKKYSRKSGKP CCCCCCCCCCCCCCC	19.73	29116813
36	Phosphorylation	TEDKKDLSGSEEDVI CCCCCCCCCCHHHHH	50.86	-
38	Phosphorylation	DKKDLSGSEEDVIEG CCCCCCCCHHHHHHC	34.14	-
46	Acetylation	EEDVIEGKTAVIEKR HHHHHHCCHHHHHHH	22.11	11792141
52	Acetylation	GKTAVIEKRRKKRSS CCHHHHHHHHHHCCC	46.51	11792151
58	Phosphorylation	EKRRKKRSSAGVVED HHHHHHCCCCCCCCC	33.16	-
59	Phosphorylation	KRRKKRSSAGVVEDM HHHHHCCCCCCCCCC	32.83	-
95	Phosphorylation	KRKRLEMYTKASLKT HHHHHHHHHHHCHHC	8.84	22468782
106	Ubiquitination	SLKTSNQKIEHVWKT CHHCCCHHHHHHHHC	55.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYCP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYCP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYCP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BLK_HUMAN	BLK	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.