Z3H7A_HUMAN - dbPTM
Z3H7A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID Z3H7A_HUMAN
UniProt AC Q8IWR0
Protein Name Zinc finger CCCH domain-containing protein 7A
Gene Name ZC3H7A
Organism Homo sapiens (Human).
Sequence Length 971
Subcellular Localization Nucleus .
Protein Description May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop..
Protein Sequence MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWNNSISQYTEALNIADYAKSEEILIPKEIIEKLYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVRAELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPSFSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTMPEAFLDDGDMVLGDELDDLLDSAPETNETVMPSALVRGPLQTASVSPSMPFSASLLGTLPIGARYAPPPSFSEFYPPLTSSLEDFCSSLNSFSMSESKRDLSTSTSREGTPLNNSNSSLLLMNGPGSLFASENFLGISSQPRNDFGNFFGSAVTKPSSSVTPRHPLEGTHELRQACQICFVKSGPKLMDFTYHANIDHKCKKDILIGRIKNVEDKSWKKIRPRPTKTNYEGPYYICKDVAAEEECRYSGHCTFAYCQEEIDVWTLERKGAFSREAFFGGNGKINLTVFKLLQEHLGEFIFLCEKCFDHKPRMISKRNKDNSTACSHPVTKHEFEDNKCLVHILRETTVKYSKIRSFHGQCQLDLCRHEVRYGCLREDECFYAHSLVELKVWIMQNETGISHDAIAQESKRYWQNLEANVPGAQVLGNQIMPGFLNMKIKFVCAQCLRNGQVIEPDKNRKYCSAKARHSWTKDRRAMRVMSIERKKWMNIRPLPTKKQMPLQFDLCNHIASGKKCQYVGNCSFAHSPEEREVWTYMKENGIQDMEQFYELWLKSQKNEKSEDIASQSNKENGKQIHMPTDYAEVTVDFHCWMCGKNCNSEKQWQGHISSEKHKEKVFHTEDDQYCWQHRFPTGYFSICDRYMNGTCPEGNSCKFAHGNAELHEWEERRDALKMKLNKARKDHLIGPNDNDFGKYSFLFKDLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2O-linked_Glycosylation------MSNVSEERR
------CCCHHHHHH		46.0330379171
16UbiquitinationRKRQQNIKEGLQFIQ
HHHHHHHHHHHHHHH		53.96-
24PhosphorylationEGLQFIQSPLSYPGT
HHHHHHHCCCCCCCC		24.0024043423
27PhosphorylationQFIQSPLSYPGTQEQ
HHHHCCCCCCCCHHH		32.4424043423
28PhosphorylationFIQSPLSYPGTQEQY
HHHCCCCCCCCHHHH		17.2324043423
31PhosphorylationSPLSYPGTQEQYAVY
CCCCCCCCHHHHHHH		25.1624043423
34UbiquitinationSYPGTQEQYAVYLRA
CCCCCHHHHHHHHHH		22.9723000965
35PhosphorylationYPGTQEQYAVYLRAL
CCCCHHHHHHHHHHH		9.4024043423
38PhosphorylationTQEQYAVYLRALVRN
CHHHHHHHHHHHHHH		5.1424043423
61UbiquitinationYREHDWNNSISQYTE
CHHCCCCCCHHHHHH		36.1422505724
62PhosphorylationREHDWNNSISQYTEA
HHCCCCCCHHHHHHH		22.0220873877
64PhosphorylationHDWNNSISQYTEALN
CCCCCCHHHHHHHHC		19.5620873877
66PhosphorylationWNNSISQYTEALNIA
CCCCHHHHHHHHCHH		10.3520873877
67PhosphorylationNNSISQYTEALNIAD
CCCHHHHHHHHCHHH		13.7220873877
85UbiquitinationSEEILIPKEIIEKLY
CCCCCCCHHHHHHHH		55.3329967540
90UbiquitinationIPKEIIEKLYINRIA
CCHHHHHHHHHCCHH		35.8629967540
124UbiquitinationSLNASNCKALYRKSK
EECHHHHHHHHHHHH		45.7529967540
130PhosphorylationCKALYRKSKALSDLG
HHHHHHHHHHHHHHH		17.7324719451
131UbiquitinationKALYRKSKALSDLGR
HHHHHHHHHHHHHHH		57.2829967540
139PhosphorylationALSDLGRYKKAYDAV
HHHHHHHHHHHHHHH		18.2929496907
140UbiquitinationLSDLGRYKKAYDAVA
HHHHHHHHHHHHHHH		29.57-
141UbiquitinationSDLGRYKKAYDAVAK
HHHHHHHHHHHHHHH		43.1529967540
143PhosphorylationLGRYKKAYDAVAKCS
HHHHHHHHHHHHHCC		17.2024719451
148UbiquitinationKAYDAVAKCSLAVPQ
HHHHHHHHCCCCCCC		20.1129967540
161UbiquitinationPQDEHVIKLTQELAQ
CCCHHHHHHHHHHHH		44.3829967540
169UbiquitinationLTQELAQKLGFKIRK
HHHHHHHHHCCCHHH		44.9929967540
186UbiquitinationVRAELSLKSVPGDGA
HHHEEECCCCCCCHH		46.1323000965
195UbiquitinationVPGDGATKALNHSVE
CCCCHHHHHCCCCHH		50.7929967540
200PhosphorylationATKALNHSVEDIEPD
HHHHCCCCHHHCCCC		26.5720873877
210PhosphorylationDIEPDLLTPRQEAVP
HCCCCCCCCCCCCCC		24.5930266825
213UbiquitinationPDLLTPRQEAVPVVS
CCCCCCCCCCCCEEE		44.1722505724
231UbiquitinationPSFSHEVGSELASVP
CCCCCCCCCCCCCCE		16.6524816145
312PhosphorylationLVRGPLQTASVSPSM
HHCCCCCCCCCCCCC		28.6924732914
314PhosphorylationRGPLQTASVSPSMPF
CCCCCCCCCCCCCCC		26.9024732914
316PhosphorylationPLQTASVSPSMPFSA
CCCCCCCCCCCCCCH		14.5721712546
318PhosphorylationQTASVSPSMPFSASL
CCCCCCCCCCCCHHH		31.4225159151
322PhosphorylationVSPSMPFSASLLGTL
CCCCCCCCHHHHCCC		15.8624732914
324UbiquitinationPSMPFSASLLGTLPI
CCCCCCHHHHCCCCC		23.9523000965
324PhosphorylationPSMPFSASLLGTLPI
CCCCCCHHHHCCCCC		23.9524732914
328PhosphorylationFSASLLGTLPIGARY
CCHHHHCCCCCCCCC		29.3624732914
334MethylationGTLPIGARYAPPPSF
CCCCCCCCCCCCCCH		23.9654560791
335UbiquitinationTLPIGARYAPPPSFS
CCCCCCCCCCCCCHH		23.9524816145
338UbiquitinationIGARYAPPPSFSEFY
CCCCCCCCCCHHHCC		29.0624816145
351UbiquitinationFYPPLTSSLEDFCSS
CCCCCCCCHHHHHHH		30.4622505724
357PhosphorylationSSLEDFCSSLNSFSM
CCHHHHHHHCHHCCC		37.5422468782
358PhosphorylationSLEDFCSSLNSFSMS
CHHHHHHHCHHCCCC		32.5222468782
365PhosphorylationSLNSFSMSESKRDLS
HCHHCCCCCHHCCCC		37.20-
374PhosphorylationSKRDLSTSTSREGTP
HHCCCCCCCCCCCCC		22.4722468782
376O-linked_GlycosylationRDLSTSTSREGTPLN
CCCCCCCCCCCCCCC		28.2730379171
383UbiquitinationSREGTPLNNSNSSLL
CCCCCCCCCCCCCEE		51.6024816145
385PhosphorylationEGTPLNNSNSSLLLM
CCCCCCCCCCCEEEE		36.7028348404
387PhosphorylationTPLNNSNSSLLLMNG
CCCCCCCCCEEEECC		23.3724719451
392UbiquitinationSNSSLLLMNGPGSLF
CCCCEEEECCCCCCC		5.7122505724
421PhosphorylationDFGNFFGSAVTKPSS
CCCCCCCCCCCCCCC		17.8928555341
425UbiquitinationFFGSAVTKPSSSVTP
CCCCCCCCCCCCCCC		35.9823000965
425AcetylationFFGSAVTKPSSSVTP
CCCCCCCCCCCCCCC		35.9826051181
425 (in isoform 1)Ubiquitination-35.9821890473
427PhosphorylationGSAVTKPSSSVTPRH
CCCCCCCCCCCCCCC		36.4821712546
428PhosphorylationSAVTKPSSSVTPRHP
CCCCCCCCCCCCCCC		37.0426471730
429PhosphorylationAVTKPSSSVTPRHPL
CCCCCCCCCCCCCCC		34.0624719451
431PhosphorylationTKPSSSVTPRHPLEG
CCCCCCCCCCCCCCC		19.2921712546
452UbiquitinationACQICFVKSGPKLMD
HCEEEEEECCCCEEE		29.4622505724
456UbiquitinationCFVKSGPKLMDFTYH
EEEECCCCEEEEEEE		61.0329967540
469UbiquitinationYHANIDHKCKKDILI
EECCCCCCCCCCEEE		43.9629967540
471UbiquitinationANIDHKCKKDILIGR
CCCCCCCCCCEEEEE		59.28-
472UbiquitinationNIDHKCKKDILIGRI
CCCCCCCCCEEEEEE		60.5129967540
480UbiquitinationDILIGRIKNVEDKSW
CEEEEEECCCCCCCC		54.2929967540
485UbiquitinationRIKNVEDKSWKKIRP
EECCCCCCCCCCCCC		44.7229967540
487UbiquitinationKNVEDKSWKKIRPRP
CCCCCCCCCCCCCCC		16.2324816145
490UbiquitinationEDKSWKKIRPRPTKT
CCCCCCCCCCCCCCC		6.9524816145
496UbiquitinationKIRPRPTKTNYEGPY
CCCCCCCCCCCCCCE		37.1429967540
507UbiquitinationEGPYYICKDVAAEEE
CCCEEEECCHHCCCC		45.7529967540
521UbiquitinationECRYSGHCTFAYCQE
CHHHCCCCCEEEECC		3.6924816145
544UbiquitinationRKGAFSREAFFGGNG
ECCCCCCEECCCCCC		48.9422505724
571UbiquitinationHLGEFIFLCEKCFDH
HHHHHHHHHHHHHCC		2.9322505724
574UbiquitinationEFIFLCEKCFDHKPR
HHHHHHHHHHCCCCC		38.9229967540
577UbiquitinationFLCEKCFDHKPRMIS
HHHHHHHCCCCCCHH		59.3722505724
579UbiquitinationCEKCFDHKPRMISKR
HHHHHCCCCCCHHCC		35.8429967540
588UbiquitinationRMISKRNKDNSTACS
CCHHCCCCCCCCCCC		63.4229967540
592PhosphorylationKRNKDNSTACSHPVT
CCCCCCCCCCCCCCC		37.63-
600UbiquitinationACSHPVTKHEFEDNK
CCCCCCCHHHCCCCC		41.1829967540
607UbiquitinationKHEFEDNKCLVHILR
HHHCCCCCEEEHHHH		41.0729967540
622UbiquitinationETTVKYSKIRSFHGQ
HHCCCHHHHHHCCCC		38.7624816145
625PhosphorylationVKYSKIRSFHGQCQL
CCHHHHHHCCCCHHH		25.68-
625UbiquitinationVKYSKIRSFHGQCQL
CCHHHHHHCCCCHHH		25.6824816145
628UbiquitinationSKIRSFHGQCQLDLC
HHHHHCCCCHHHHCC		28.1324816145
679UbiquitinationDAIAQESKRYWQNLE
HHHHHHHHHHHHHHH		49.0729967540
681PhosphorylationIAQESKRYWQNLEAN
HHHHHHHHHHHHHHC		18.32-
682UbiquitinationAQESKRYWQNLEANV
HHHHHHHHHHHHHCC		5.6622505724
709UbiquitinationGFLNMKIKFVCAQCL
CCHHCHHHHHHHHHH		26.6529967540
709MalonylationGFLNMKIKFVCAQCL
CCHHCHHHHHHHHHH		26.6526320211
723UbiquitinationLRNGQVIEPDKNRKY
HHCCCEECCCCCCCC		48.9022505724
726UbiquitinationGQVIEPDKNRKYCSA
CCEECCCCCCCCCCH		70.1724816145
729UbiquitinationIEPDKNRKYCSAKAR
ECCCCCCCCCCHHHH		61.0624816145
734UbiquitinationNRKYCSAKARHSWTK
CCCCCCHHHHCCCCC		29.6529967540
738PhosphorylationCSAKARHSWTKDRRA
CCHHHHCCCCCCHHH		30.7824719451
741UbiquitinationKARHSWTKDRRAMRV
HHHCCCCCCHHHHHC		42.8729967540
750PhosphorylationRRAMRVMSIERKKWM
HHHHHCCEEEEHHCC		20.5917081983
755UbiquitinationVMSIERKKWMNIRPL
CCEEEEHHCCCCCCC		58.8729967540
764PhosphorylationMNIRPLPTKKQMPLQ
CCCCCCCCCCCCCCC		59.5622964224
766UbiquitinationIRPLPTKKQMPLQFD
CCCCCCCCCCCCCEE		55.0729967540
780PhosphorylationDLCNHIASGKKCQYV
ECHHHHHCCCCCEEE		51.0125159151
782UbiquitinationCNHIASGKKCQYVGN
HHHHHCCCCCEEECC		48.1329967540
782AcetylationCNHIASGKKCQYVGN
HHHHHCCCCCEEECC		48.1325953088
783UbiquitinationNHIASGKKCQYVGNC
HHHHCCCCCEEECCC		30.0522505724
786PhosphorylationASGKKCQYVGNCSFA
HCCCCCEEECCCCCC		21.57-
822UbiquitinationQFYELWLKSQKNEKS
HHHHHHHHHHCCCCH		38.9829967540
828UbiquitinationLKSQKNEKSEDIASQ
HHHHCCCCHHHHHHH		69.4129967540
829PhosphorylationKSQKNEKSEDIASQS
HHHCCCCHHHHHHHH		34.03-
834PhosphorylationEKSEDIASQSNKENG
CCHHHHHHHHHHHCC		34.18-
836PhosphorylationSEDIASQSNKENGKQ
HHHHHHHHHHHCCCC		47.58-
838UbiquitinationDIASQSNKENGKQIH
HHHHHHHHHCCCCCC		58.7829967540
861UbiquitinationTVDFHCWMCGKNCNS
EEEEEEEECCCCCCC		2.3522505724
867UbiquitinationWMCGKNCNSEKQWQG
EECCCCCCCCHHHCC		63.7022505724
870UbiquitinationGKNCNSEKQWQGHIS
CCCCCCCHHHCCCCC		57.5729967540
870AcetylationGKNCNSEKQWQGHIS
CCCCCCCHHHCCCCC		57.5726051181
880UbiquitinationQGHISSEKHKEKVFH
CCCCCCHHHHHHEEE		63.0229967540
882UbiquitinationHISSEKHKEKVFHTE
CCCCHHHHHHEEECC		71.01-
884UbiquitinationSSEKHKEKVFHTEDD
CCHHHHHHEEECCCC		55.8129967540
893PhosphorylationFHTEDDQYCWQHRFP
EECCCCCCEECCCCC		11.5827642862
903PhosphorylationQHRFPTGYFSICDRY
CCCCCCCEEECHHHH		9.1620090780
941AcetylationEERRDALKMKLNKAR
HHHHHHHHHHHHHHH		35.3924885377
941UbiquitinationEERRDALKMKLNKAR
HHHHHHHHHHHHHHH		35.3929967540
943AcetylationRRDALKMKLNKARKD
HHHHHHHHHHHHHHH		47.5224885385
949UbiquitinationMKLNKARKDHLIGPN
HHHHHHHHHCCCCCC		55.1229967540
962UbiquitinationPNDNDFGKYSFLFKD
CCCCCCHHHEEEEEC		37.4022505724
962AcetylationPNDNDFGKYSFLFKD
CCCCCCHHHEEEEEC		37.4026051181
963PhosphorylationNDNDFGKYSFLFKDL
CCCCCHHHEEEEECC		12.6828555341
964PhosphorylationDNDFGKYSFLFKDLN
CCCCHHHEEEEECCC		20.9624247654
968UbiquitinationGKYSFLFKDLN----
HHHEEEEECCC----		64.5522505724
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of Z3H7A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of Z3H7A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of Z3H7A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of Z3H7A_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of Z3H7A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-750, AND MASSSPECTROMETRY.

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