CROCC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CROCC_HUMAN
• UniProt AC: Q5TZA2
• Protein Name: Rootletin
• Gene Name: CROCC {ECO:0000312|EMBL:CAH70055.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 2017
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . In ciliated cells, associated with ciliary rootlets. In
• Protein Description: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis. [PubMed: 27623382 Contributes to centrosome cohesion before mitosis]
• Protein Sequence: MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	VEDLLAQSRAERDEL HHHHHHHCHHHHHHH	28.05	25599653
154	Phosphorylation	QLQEEQASYRRKLQA HHHHHHHHHHHHHHH	20.90	24719451
155	Phosphorylation	LQEEQASYRRKLQAY HHHHHHHHHHHHHHH	19.90	24719451
229	Phosphorylation	LEEEQQRSASLAQVN HHHHHHHCHHHHHHH	20.19	30576742
284	Phosphorylation	AWRREEESFNAYFSN HHHHHHHHHHHHCCC	27.38	28555341
288	Phosphorylation	EEESFNAYFSNEHSR HHHHHHHHCCCHHHH	14.51	-
320	Ubiquitination	VKMFTERDLLQLGGE HHHCCHHHHHHHHHH	45.56	24816145
379	Ubiquitination	RDKVLREKDLAQQQM HHHHHHHHHHHHHHH	52.16	29967540
392	Ubiquitination	QMQSDLDKADLSARV HHHHHHHHHHHHHHH	51.61	24816145
394	Ubiquitination	QSDLDKADLSARVTE HHHHHHHHHHHHHHH	47.07	24816145
400	Phosphorylation	ADLSARVTELGLAVK HHHHHHHHHHHHHHH	21.68	21406692
426	Ubiquitination	VNKDLTEKLEALESL CCHHHHHHHHHHHHH	46.52	29967540
432	Phosphorylation	EKLEALESLRLQEQA HHHHHHHHHHHHHHH	21.46	19413330
462	Phosphorylation	DLAQAVLSDSESGVQ HHHHHHHCCCCCCCC	32.27	30266825
464	Phosphorylation	AQAVLSDSESGVQLS HHHHHCCCCCCCCCC	30.22	30266825
466	Phosphorylation	AVLSDSESGVQLSGS HHHCCCCCCCCCCCC	48.49	30266825
471	Phosphorylation	SESGVQLSGSERTAD CCCCCCCCCCCCEEC	24.15	30266825
473	Phosphorylation	SGVQLSGSERTADAS CCCCCCCCCCEECCC	22.11	21406692
480	Phosphorylation	SERTADASNGSLRGL CCCEECCCCCCCCCC	42.12	29802988
483	Phosphorylation	TADASNGSLRGLSGQ EECCCCCCCCCCCCC	21.10	25850435
488	Phosphorylation	NGSLRGLSGQRTPSP CCCCCCCCCCCCCCC	35.39	30266825
492	Phosphorylation	RGLSGQRTPSPPRRS CCCCCCCCCCCCCCC	21.89	30266825
494	Phosphorylation	LSGQRTPSPPRRSSP CCCCCCCCCCCCCCC	47.09	30266825
499	Phosphorylation	TPSPPRRSSPGRGRS CCCCCCCCCCCCCCC	42.01	21406692
500	Phosphorylation	PSPPRRSSPGRGRSP CCCCCCCCCCCCCCC	29.57	30576142
506	Phosphorylation	SSPGRGRSPRRGPSP CCCCCCCCCCCCCCC	26.11	-
512	Phosphorylation	RSPRRGPSPACSDSS CCCCCCCCCCCCCHH	28.14	23401153
516	Phosphorylation	RGPSPACSDSSTLAL CCCCCCCCCHHHHHH	42.51	25850435
518	Phosphorylation	PSPACSDSSTLALIH CCCCCCCHHHHHHHH	14.66	25850435
519	Phosphorylation	SPACSDSSTLALIHS CCCCCCHHHHHHHHH	32.22	25850435
520	Phosphorylation	PACSDSSTLALIHSA CCCCCHHHHHHHHHH	21.72	25850435
526	Phosphorylation	STLALIHSALHKRQL HHHHHHHHHHHHCCC	26.07	27251275
602	Phosphorylation	RSANELLSREKSNLA HHHHHHHHHHHHHHH	51.52	24719451
712	Acetylation	EVAEALTKAEAGRVE HHHHHHHHHHCCCCE	45.11	20167786
723	Phosphorylation	GRVELELSMTKLRAE CCCEEEEEHHHHHHH	18.28	27794612
725	Phosphorylation	VELELSMTKLRAEEA CEEEEEHHHHHHHHH	24.45	27794612
737	Phosphorylation	EEASLQDSLSKLSAL HHHHHHHHHHHHHHH	22.91	24719451
739	Phosphorylation	ASLQDSLSKLSALNE HHHHHHHHHHHHHCH	35.19	27251275
807	Phosphorylation	ARQGLEGSLRVAEQA HHCHHHHHHHHHHHH	12.02	-
830	Phosphorylation	PTLRHERSQLQEQLA HHHHHHHHHHHHHHH	32.05	-
844	Phosphorylation	AQLSRQLSGREQELE HHHHHHHHCHHHHHH	27.71	-
958	Phosphorylation	LRQQIIATQEKASLD HHHHHHHHHHHHHCC	27.18	24719451
1065	Phosphorylation	SEKQQALSLKESEKT HHHHHHHCCCHHHHH	40.17	24719451
1065	O-linked_Glycosylation	SEKQQALSLKESEKT HHHHHHHCCCHHHHH	40.17	30379171
1109	Phosphorylation	RQEQDRSTVNALTSE HHHHHHHHHHHHHHH	20.76	25690035
1151	Phosphorylation	DLGKQRDSCLREAEE HHHHHHHHHHHHHHH	19.76	-
1218	Phosphorylation	EREALRRSNEELRSA HHHHHHHCHHHHHHH	42.00	29802988
1224	Phosphorylation	RSNEELRSAVKKAES HCHHHHHHHHHHHHH	50.46	30266825
1231	Phosphorylation	SAVKKAESERISLKL HHHHHHHHHHHHHHH	36.71	30266825
1259	Ubiquitination	EARTAVGKEAGELRT HHHHHHHHHHHHHHH	37.48	29967540
1290	Ubiquitination	QELRRQMKMLDSENT HHHHHHHHHHHCCCH	28.15	29967540
1390	Ubiquitination	HARGLELKLEAARAE HHHHHHHHHHHHHHH	34.60	-
1442	Methylation	GLRSALRRGLGLGRA HHHHHHHHCCCCCCC	45.60	-
1451	Phosphorylation	LGLGRAPSPAPRPVP CCCCCCCCCCCCCCC	32.48	26055452
1460	Phosphorylation	APRPVPGSPARDAPA CCCCCCCCCCCCCCC	14.87	30266825
1470	Phosphorylation	RDAPAEGSGEGLNSP CCCCCCCCCCCCCCC	25.77	25850435
1476	Phosphorylation	GSGEGLNSPSTLECS CCCCCCCCCCCCCCC	25.85	25850435
1478	Phosphorylation	GEGLNSPSTLECSPG CCCCCCCCCCCCCCC	45.50	25850435
1479	Phosphorylation	EGLNSPSTLECSPGS CCCCCCCCCCCCCCC	29.93	25850435
1483	Phosphorylation	SPSTLECSPGSQPPS CCCCCCCCCCCCCCC	23.95	25850435
1486	Phosphorylation	TLECSPGSQPPSPGP CCCCCCCCCCCCCCC	42.78	25850435
1490	Phosphorylation	SPGSQPPSPGPATSP CCCCCCCCCCCCCCC	49.53	25850435
1495	Phosphorylation	PPSPGPATSPASPDL CCCCCCCCCCCCCCC	38.07	27251275
1496	Phosphorylation	PSPGPATSPASPDLD CCCCCCCCCCCCCCC	22.15	27251275
1499	Phosphorylation	GPATSPASPDLDPEA CCCCCCCCCCCCHHH	23.49	27251275
1575	Phosphorylation	RSVDGRLSGVQAELA HHHCCCHHHHHHHHH	35.24	28555341
1587	Phosphorylation	ELALQEESVRRSERE HHHHCHHHHHHHHHH	21.85	27251275
1598	Phosphorylation	SERERRATLDQVATL HHHHHHHHHHHHHHH	29.11	27251275
1608	Phosphorylation	QVATLERSLQATESE HHHHHHHHHHHHHHH	18.56	26437602
1612	Phosphorylation	LERSLQATESELRAS HHHHHHHHHHHHHHC	27.38	29978859
1614	Phosphorylation	RSLQATESELRASQE HHHHHHHHHHHHCHH	37.26	29978859
1619	Phosphorylation	TESELRASQEKISKM HHHHHHHCHHHHHHH	32.22	25849741
1622	Ubiquitination	ELRASQEKISKMKAN HHHHCHHHHHHHHHC	44.64	29967540
1647	Phosphorylation	LKEVLDASESRTVKL HHHHHHHCCCCCHHH	35.45	23911959
1660	Phosphorylation	KLELQRRSLEGELQR HHHHHHHHHHHHHHH	32.72	25159151
1685	Methylation	QAQALQDRVDSLQRQ HHHHHHHHHHHHHHH	22.60	-
1732	Phosphorylation	RDKVRGLTEALAQSS HHHHHHHHHHHHHCH	23.26	22210691
1741	Phosphorylation	ALAQSSASLNSTRDK HHHHCHHHCCCCCCC	29.99	22210691
1832	Phosphorylation	GEAAALNTVQKLQDE HHHHHHHHHHHHHHH	25.76	22817900
1849	Phosphorylation	LLQERLGSLQRALAQ HHHHHHHHHHHHHHH	26.39	22817900
1892	Phosphorylation	VEREKLRSHEDTVRL HHHHHHHCCHHHHHH	41.48	23312004
1892	O-linked_Glycosylation	VEREKLRSHEDTVRL HHHHHHHCCHHHHHH	41.48	30379171
1900	Phosphorylation	HEDTVRLSAEKGRLD CHHHHHHHHHCCCCC	24.66	28985074
1909	Phosphorylation	EKGRLDRTLTGAELE HCCCCCCCCCHHHHH	28.48	27251275
1911	Phosphorylation	GRLDRTLTGAELELA CCCCCCCCHHHHHHH	33.46	28857561
1937	Phosphorylation	QVVVLEQSHSPAQLE HEEEEECCCCCHHHH	19.29	28348404
1939	Phosphorylation	VVLEQSHSPAQLEVD EEEECCCCCHHHHHH	27.46	26657352
2004	Phosphorylation	LQQELRRSSAPFSPP HHHHHHHCCCCCCCC	25.15	22199227
2005	Phosphorylation	QQELRRSSAPFSPPS HHHHHHCCCCCCCCC	37.84	25159151
2009	Phosphorylation	RRSSAPFSPPSGPPE HHCCCCCCCCCCCCC	34.54	25159151
2012	Phosphorylation	SAPFSPPSGPPEK-- CCCCCCCCCCCCC--	68.28	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CROCC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CROCC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CROCC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RN152_HUMAN	RNF152	physical	21988832
HDGF_HUMAN	HDGF	physical	22863883
XBP1_HUMAN	XBP1	physical	28514442
PEX14_HUMAN	PEX14	physical	28514442
PUSL1_HUMAN	PUSL1	physical	28514442
SRBD1_HUMAN	SRBD1	physical	28514442
UBR1_HUMAN	UBR1	physical	28514442
GIT1_HUMAN	GIT1	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
SCOC_HUMAN	SCOC	physical	28514442
UBR2_HUMAN	UBR2	physical	28514442
TGFA1_HUMAN	TGFBRAP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1619, AND MASSSPECTROMETRY.
PubMed: 17525332