dbPTM

GPBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPBL1_HUMAN
UniProt AC	Q9HC44
Protein Name	Vasculin-like protein 1
Gene Name	GPBP1L1
Organism	Homo sapiens (Human).
Sequence Length	474
Subcellular Localization	Nucleus .
Protein Description	Possible transcription factor..
Protein Sequence	MAQHDFVPAWLNFSTPQSAKSPTATFEKHGEHLPRGEGRFGVSRRRHNSSDGFFNNGPLRTAGDSWHQPSLFRHDSVDSGVSKGAYAGITGNPSGWHSSSRGHDGMSQRSGGGTGNHRHWNGSFHSRKGCAFQEKPPMEIREEKKEDKVEKLQFEEEDFPSLNPEAGKQHQPCRPIGTPSGVWENPPSAKQPSKMLVIKKVSKEDPAAAFSAAFTSPGSHHANGNKLSSVVPSVYKNLVPKPVPPPSKPNAWKANRMEHKSGSLSSSRESAFTSPISVTKPVVLASGAALSSPKESPSSTTPPIEISSSRLTKLTRRTTDRKSEFLKTLKDDRNGDFSENRDCDKLEDLEDNSTPEPKENGEEGCHQNGLALPVVEEGEVLSHSLEAEHRLLKAMGWQEYPENDENCLPLTEDELKEFHMKTEQLRRNGFGKNGFLQSRSSSLFSPWRSTCKAEFEDSDTETSSSETSDDDAWK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	VPAWLNFSTPQSAKS CCEECCCCCCCCCCC	37.80	28450419
15	Phosphorylation	PAWLNFSTPQSAKSP CEECCCCCCCCCCCC	22.62	28450419
18	Phosphorylation	LNFSTPQSAKSPTAT CCCCCCCCCCCCCCC	38.58	25106551
21	Phosphorylation	STPQSAKSPTATFEK CCCCCCCCCCCCHHH	27.48	29255136
23	Phosphorylation	PQSAKSPTATFEKHG CCCCCCCCCCHHHCC	45.48	29255136
25	Phosphorylation	SAKSPTATFEKHGEH CCCCCCCCHHHCCCC	34.50	28450419
43	Phosphorylation	GEGRFGVSRRRHNSS CCCCCCCCCCCCCCC	22.05	22985185
49	Phosphorylation	VSRRRHNSSDGFFNN CCCCCCCCCCCCCCC	24.55	22167270
50	Phosphorylation	SRRRHNSSDGFFNNG CCCCCCCCCCCCCCC	47.25	27273156
61	Phosphorylation	FNNGPLRTAGDSWHQ CCCCCCCCCCCCCCC	42.55	23186163
65	Phosphorylation	PLRTAGDSWHQPSLF CCCCCCCCCCCCCCC	26.07	23186163
70	Phosphorylation	GDSWHQPSLFRHDSV CCCCCCCCCCCCCCC	33.30	23917254
76	Phosphorylation	PSLFRHDSVDSGVSK CCCCCCCCCCCCCCC	23.00	27273156
79	Phosphorylation	FRHDSVDSGVSKGAY CCCCCCCCCCCCCCC	38.65	29396449
82	Phosphorylation	DSVDSGVSKGAYAGI CCCCCCCCCCCCEEC	28.97	23403867
86	Phosphorylation	SGVSKGAYAGITGNP CCCCCCCCEECCCCC	17.65	27642862
90	Phosphorylation	KGAYAGITGNPSGWH CCCCEECCCCCCCCC	29.95	-
94	Phosphorylation	AGITGNPSGWHSSSR EECCCCCCCCCCCCC	59.52	-
98	Phosphorylation	GNPSGWHSSSRGHDG CCCCCCCCCCCCCCC	24.41	25159151
99	Phosphorylation	NPSGWHSSSRGHDGM CCCCCCCCCCCCCCC	15.92	27080861
100	Phosphorylation	PSGWHSSSRGHDGMS CCCCCCCCCCCCCCC	45.34	27080861
101	Methylation	SGWHSSSRGHDGMSQ CCCCCCCCCCCCCCC	48.70	-
109	Methylation	GHDGMSQRSGGGTGN CCCCCCCCCCCCCCC	29.93	-
123	Phosphorylation	NHRHWNGSFHSRKGC CCCCCCCCCCCCCCC	19.30	21406692
126	Phosphorylation	HWNGSFHSRKGCAFQ CCCCCCCCCCCCCCC	33.41	21406692
161	Phosphorylation	FEEEDFPSLNPEAGK CCCCCCCCCCCCCCC	40.55	27251275
193	Phosphorylation	PPSAKQPSKMLVIKK CCCCCCCCCEEEEEE	28.36	30576142
199	Methylation	PSKMLVIKKVSKEDP CCCEEEEEECCCCCH	39.38	23644510
200	Methylation	SKMLVIKKVSKEDPA CCEEEEEECCCCCHH	40.39	23644510
202	Phosphorylation	MLVIKKVSKEDPAAA EEEEEECCCCCHHHH	38.93	30108239
203	Acetylation	LVIKKVSKEDPAAAF EEEEECCCCCHHHHH	69.95	7297989
203	Methylation	LVIKKVSKEDPAAAF EEEEECCCCCHHHHH	69.95	23644510
211	Phosphorylation	EDPAAAFSAAFTSPG CCHHHHHHHHHCCCC	17.60	21406692
215	Phosphorylation	AAFSAAFTSPGSHHA HHHHHHHCCCCCCCC	29.32	21406692
216	Phosphorylation	AFSAAFTSPGSHHAN HHHHHHCCCCCCCCC	22.32	25159151
219	Phosphorylation	AAFTSPGSHHANGNK HHHCCCCCCCCCCCC	18.58	21406692
228	Phosphorylation	HANGNKLSSVVPSVY CCCCCCHHHCCCHHH	23.77	-
229	Phosphorylation	ANGNKLSSVVPSVYK CCCCCHHHCCCHHHC	37.25	-
233	Phosphorylation	KLSSVVPSVYKNLVP CHHHCCCHHHCCCCC	26.86	28555341
235	Phosphorylation	SSVVPSVYKNLVPKP HHCCCHHHCCCCCCC	9.86	28555341
248	Acetylation	KPVPPPSKPNAWKAN CCCCCCCCCCCCHHH	48.33	25953088
253	Methylation	PSKPNAWKANRMEHK CCCCCCCHHHCCCCC	33.11	-
265	Phosphorylation	EHKSGSLSSSRESAF CCCCCCCCCCCHHHC	28.15	-
270	Phosphorylation	SLSSSRESAFTSPIS CCCCCCHHHCCCCCC	27.80	28450419
273	Phosphorylation	SSRESAFTSPISVTK CCCHHHCCCCCCCCC	33.05	26657352
274	Phosphorylation	SRESAFTSPISVTKP CCHHHCCCCCCCCCC	17.49	25159151
277	Phosphorylation	SAFTSPISVTKPVVL HHCCCCCCCCCCEEE	27.41	28450419
279	Phosphorylation	FTSPISVTKPVVLAS CCCCCCCCCCEEEEC	23.88	28450419
286	Phosphorylation	TKPVVLASGAALSSP CCCEEEECCCCCCCC	25.46	22199227
291	Phosphorylation	LASGAALSSPKESPS EECCCCCCCCCCCCC	39.61	22199227
292	Phosphorylation	ASGAALSSPKESPSS ECCCCCCCCCCCCCC	40.62	25159151
296	Phosphorylation	ALSSPKESPSSTTPP CCCCCCCCCCCCCCC	35.89	29255136
298	Phosphorylation	SSPKESPSSTTPPIE CCCCCCCCCCCCCEE	49.98	30266825
299	Phosphorylation	SPKESPSSTTPPIEI CCCCCCCCCCCCEEE	39.42	26657352
300	Phosphorylation	PKESPSSTTPPIEIS CCCCCCCCCCCEEEC	47.89	30266825
301	Phosphorylation	KESPSSTTPPIEISS CCCCCCCCCCEEECH	29.08	30266825
307	Phosphorylation	TTPPIEISSSRLTKL CCCCEEECHHHHHHH	14.96	30266825
308	Phosphorylation	TPPIEISSSRLTKLT CCCEEECHHHHHHHH	25.74	30266825
309	Phosphorylation	PPIEISSSRLTKLTR CCEEECHHHHHHHHH	25.23	30266825
319	Phosphorylation	TKLTRRTTDRKSEFL HHHHHHCCCCHHHHH	31.81	-
353	Phosphorylation	LEDLEDNSTPEPKEN HHHCCCCCCCCCCCC	58.63	21815630
354	Phosphorylation	EDLEDNSTPEPKENG HHCCCCCCCCCCCCC	37.62	23401153
382	Phosphorylation	VEEGEVLSHSLEAEH EECCCEECCCHHHHH	19.06	23401153
384	Phosphorylation	EGEVLSHSLEAEHRL CCCEECCCHHHHHHH	25.24	25159151
400	Phosphorylation	KAMGWQEYPENDENC HHCCCCCCCCCCCCC	10.76	-
411	Phosphorylation	DENCLPLTEDELKEF CCCCCCCCHHHHHHH	39.18	-
438	Phosphorylation	GKNGFLQSRSSSLFS CCCCCCCCCCCCCCC	35.96	26546556
440	Phosphorylation	NGFLQSRSSSLFSPW CCCCCCCCCCCCCCC	29.53	28450419
441	Phosphorylation	GFLQSRSSSLFSPWR CCCCCCCCCCCCCCH	29.92	30576142
442	Phosphorylation	FLQSRSSSLFSPWRS CCCCCCCCCCCCCHH	34.38	28450419
445	Phosphorylation	SRSSSLFSPWRSTCK CCCCCCCCCCHHHEE	28.92	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPBL1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPBL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKHF2_HUMAN	PLEKHF2	physical	16189514
GATA_HUMAN	QRSL1	physical	28514442
TAC2N_HUMAN	TC2N	physical	28514442
PLCD3_HUMAN	PLCD3	physical	28514442
KANL2_HUMAN	KANSL2	physical	28514442
CNO11_HUMAN	CNOT11	physical	28514442
AMPD2_HUMAN	AMPD2	physical	28514442
ZBTB1_HUMAN	ZBTB1	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
UTP6_HUMAN	UTP6	physical	28514442
CNO10_HUMAN	CNOT10	physical	28514442
CNOT2_HUMAN	CNOT2	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
AP2A1_HUMAN	AP2A1	physical	28514442
AP2A2_HUMAN	AP2A2	physical	28514442
ECD_HUMAN	ECD	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
CNOT1_HUMAN	CNOT1	physical	28514442
EIF3A_HUMAN	EIF3A	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
AP1B1_HUMAN	AP1B1	physical	28514442
CNOT8_HUMAN	CNOT8	physical	28514442
EIF3E_HUMAN	EIF3E	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
DCAF5_HUMAN	DCAF5	physical	28514442
EIF3C_HUMAN	EIF3C	physical	28514442
EIF3H_HUMAN	EIF3H	physical	28514442
AP2S1_HUMAN	AP2S1	physical	28514442
CNO6L_HUMAN	CNOT6L	physical	28514442
PDD2L_HUMAN	PDCD2L	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
AP2M1_HUMAN	AP2M1	physical	28514442
EIF3M_HUMAN	EIF3M	physical	28514442
CNOT9_HUMAN	RQCD1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPBL1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.	18220336 [Abstract]