TAC2N_HUMAN - dbPTM
TAC2N_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAC2N_HUMAN
UniProt AC Q8N9U0
Protein Name Tandem C2 domains nuclear protein
Gene Name TC2N
Organism Homo sapiens (Human).
Sequence Length 490
Subcellular Localization Nucleus.
Protein Description
Protein Sequence MATEFIKSCCGGCFYGETEKHNFSVERDFKAAVPNSQNATISVPPLTSVSVKPQLGCTEDYLLSKLPSDGKEVPFVVPKFKLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRFPPRSEVKRLYGSVCDLRTNKLPGSPGLSKSMFDLTNSSQRFIQRHDSLSSVPSSSSSRKNSQGSNRSLDTITLSGDERDFGRLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKGILTLPKPVHFKSSAKEGSNAIEFMETFVFAIKLQNLQTVRLVFKIQTQTPRKKTIGECSMSLRTLSTQEMDYSLDITPPSKISVCHAELELGTCFQAVNSRIQLQILEARYLPSSSTPLTLSFFVKVGMFSSGELIYKKKTRLLKASNGRVKWGETMIFPLIQSEKEIVFLIKLYSRSSVRRKHFVGQIWISEDSNNIEAVNQWKETVINPEKVVIRWHKLNPS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MATEFIKSCCGGCF
-CCHHHHHHHCCCCC		42.6429901268
15PhosphorylationSCCGGCFYGETEKHN
HHCCCCCCCCHHHCC		20.37-
24PhosphorylationETEKHNFSVERDFKA
CHHHCCCEEEEEHHC		28.5223312004
58PhosphorylationVKPQLGCTEDYLLSK
CCCCCCCCHHHHHHC		30.05-
61PhosphorylationQLGCTEDYLLSKLPS
CCCCCHHHHHHCCCC		11.8725627689
64PhosphorylationCTEDYLLSKLPSDGK
CCHHHHHHCCCCCCC		29.56-
83PhosphorylationVVPKFKLSYIQPRTQ
EEEEEEEEEECCCCC		22.3026657352
84PhosphorylationVPKFKLSYIQPRTQE
EEEEEEEEECCCCCC		17.6328060719
92PhosphorylationIQPRTQETPSHLEEL
ECCCCCCCCCHHHHH		21.9228060719
102PhosphorylationHLEELEGSARASFGD
HHHHHCCCCCCCCCC		12.7628060719
106PhosphorylationLEGSARASFGDRKVE
HCCCCCCCCCCEEEE		24.9824719451
115PhosphorylationGDRKVELSSSSQHGP
CCEEEEECCCCCCCC		18.0527642862
116PhosphorylationDRKVELSSSSQHGPS
CEEEEECCCCCCCCC		46.7828270605
117PhosphorylationRKVELSSSSQHGPSY
EEEEECCCCCCCCCC		30.5528270605
118PhosphorylationKVELSSSSQHGPSYD
EEEECCCCCCCCCCC		28.3028270605
123PhosphorylationSSSQHGPSYDVYNPF
CCCCCCCCCCCCCCC		38.2627642862
124PhosphorylationSSQHGPSYDVYNPFY
CCCCCCCCCCCCCCH		16.7428270605
127PhosphorylationHGPSYDVYNPFYMYQ
CCCCCCCCCCCHHHH		17.7728270605
131PhosphorylationYDVYNPFYMYQHISP
CCCCCCCHHHHCCCC		9.0026657352
133PhosphorylationVYNPFYMYQHISPDL
CCCCCHHHHCCCCCH		5.8828270605
137PhosphorylationFYMYQHISPDLSRRF
CHHHHCCCCCHHHCC		15.3825849741
141PhosphorylationQHISPDLSRRFPPRS
HCCCCCHHHCCCCHH		28.8828270605
154PhosphorylationRSEVKRLYGSVCDLR
HHHHHHHHCCHHHCC		16.0429978859
156PhosphorylationEVKRLYGSVCDLRTN
HHHHHHCCHHHCCCC		13.1523401153
162PhosphorylationGSVCDLRTNKLPGSP
CCHHHCCCCCCCCCC		43.9628060719
168PhosphorylationRTNKLPGSPGLSKSM
CCCCCCCCCCCCHHH		17.5425159151
172PhosphorylationLPGSPGLSKSMFDLT
CCCCCCCCHHHHHCC		28.7129978859
174PhosphorylationGSPGLSKSMFDLTNS
CCCCCCHHHHHCCHH		22.7028355574
179PhosphorylationSKSMFDLTNSSQRFI
CHHHHHCCHHHHHHH		34.59-
181PhosphorylationSMFDLTNSSQRFIQR
HHHHCCHHHHHHHHH		23.7128060719
182PhosphorylationMFDLTNSSQRFIQRH
HHHCCHHHHHHHHHH		27.6928060719
191PhosphorylationRFIQRHDSLSSVPSS
HHHHHHHCCCCCCCC		24.8325849741
193PhosphorylationIQRHDSLSSVPSSSS
HHHHHCCCCCCCCCC		32.9928060719
194PhosphorylationQRHDSLSSVPSSSSS
HHHHCCCCCCCCCCC		43.2528060719
197PhosphorylationDSLSSVPSSSSSRKN
HCCCCCCCCCCCCCC		40.4728060719
198PhosphorylationSLSSVPSSSSSRKNS
CCCCCCCCCCCCCCC		28.3328060719
199PhosphorylationLSSVPSSSSSRKNSQ
CCCCCCCCCCCCCCC		36.3528060719
200PhosphorylationSSVPSSSSSRKNSQG
CCCCCCCCCCCCCCC		35.7928060719
201PhosphorylationSVPSSSSSRKNSQGS
CCCCCCCCCCCCCCC		49.5828060719
205PhosphorylationSSSSRKNSQGSNRSL
CCCCCCCCCCCCCCC		38.6727362937
208PhosphorylationSRKNSQGSNRSLDTI
CCCCCCCCCCCCCEE		22.7927362937
211PhosphorylationNSQGSNRSLDTITLS
CCCCCCCCCCEEEEC		34.5430278072
214PhosphorylationGSNRSLDTITLSGDE
CCCCCCCEEEECCCC		22.5828348404
216PhosphorylationNRSLDTITLSGDERD
CCCCCEEEECCCCCC		19.5727499020
218PhosphorylationSLDTITLSGDERDFG
CCCEEEECCCCCCCC		35.2327362937
313PhosphorylationRLVFKIQTQTPRKKT
EEEEEEECCCCCCCC		37.5729514088
315PhosphorylationVFKIQTQTPRKKTIG
EEEEECCCCCCCCHH		28.5729514088
320O-linked_GlycosylationTQTPRKKTIGECSMS
CCCCCCCCHHCCCEE		36.9330379171
325PhosphorylationKKTIGECSMSLRTLS
CCCHHCCCEEEEECC		13.7028060719
327PhosphorylationTIGECSMSLRTLSTQ
CHHCCCEEEEECCCC		9.8228060719
330PhosphorylationECSMSLRTLSTQEMD
CCCEEEEECCCCCCE		30.2928348404
332PhosphorylationSMSLRTLSTQEMDYS
CEEEEECCCCCCEEE		27.6828348404
333PhosphorylationMSLRTLSTQEMDYSL
EEEEECCCCCCEEEC		31.4928348404
382PhosphorylationARYLPSSSTPLTLSF
EEECCCCCCCEEEEE		38.0828348404
383PhosphorylationRYLPSSSTPLTLSFF
EECCCCCCCEEEEEE		25.0228348404
388PhosphorylationSSTPLTLSFFVKVGM
CCCCEEEEEEEEECC		16.05-
403PhosphorylationFSSGELIYKKKTRLL
CCCCCEEEEECCEEE		29.4025627689
407PhosphorylationELIYKKKTRLLKASN
CEEEEECCEEEECCC		35.1124732914
422PhosphorylationGRVKWGETMIFPLIQ
CCCEECCEEEEEEEC		16.1929052541
430PhosphorylationMIFPLIQSEKEIVFL
EEEEEECCCCCEEEE		43.5829052541
442PhosphorylationVFLIKLYSRSSVRRK
EEEEEHHHCCCCCHH		35.8024719451
473PhosphorylationAVNQWKETVINPEKV
HHHHHHHCCCCHHHE		23.9824719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAC2N_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAC2N_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAC2N_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TAC2N_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAC2N_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-168; SER-211;THR-214; THR-216 AND SER-218, AND MASS SPECTROMETRY.

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