ANS1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANS1B_HUMAN
• UniProt AC: Q7Z6G8
• Protein Name: Ankyrin repeat and sterile alpha motif domain-containing protein 1B
• Gene Name: ANKS1B
• Organism: Homo sapiens (Human).
• Sequence Length: 1248
• Subcellular Localization: Cytoplasm .; Isoform 2: Nucleus.; Isoform 3: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation
• Protein Description: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing..
• Protein Sequence: MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQEYLEGVGRSTVLEEPVQEDATQETHISSPVESPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLDNLSKISEEELGKNGSQSVRTSSTINLSPGEVEEEDDDENTCGPSGLWEALTPCNGCRNLGFPMLAQESYPKKRNYTMEIVPSASLDTFPSENENFLCDLMDTAVTKKPCSLEIARAPSPRTDNASEVAVTTPGTSNHRNSSTGPTPDCSPPSPDTALKNIVKVIRPQPKQRTSIVSSLDFHRMNHNQEYFEINTSTGCTSFTASPPASPPTSSVGTTEVKNEGTNHTDDLSRQDDNDPPKEYDPGQFAGLLHGSSPACESPENPFHLYGKREQCEKGQDEVSLANSPLPFKQSPIENNSEPLVKKIKPKVVSRTIFHKKSNQLENHTIVGTRSTRSGSRNGDQWVMNAGGFVERACTLGRIRSLPKALIDMHLSKSVSKSDSDLIAYPSNEKTSRVNWSESSTAEHSSKGNSERTPSFTSEWEEIDKIMSSIDVGINNELKEMNGETTRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSIRKSVDLLHASHTGQEPSERHTEEALRKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	LPLSNLLSIWRGPNV CCHHHHHHHHCCCCC	24.22	24719451
192	Phosphorylation	PNLMSCNTRKHTPLH CCHHCCCCCCCCCCH	45.48	68723321
194	Ubiquitination	LMSCNTRKHTPLHLA HHCCCCCCCCCCHHH	50.20	-
303	Phosphorylation	EPVQEDATQETHISS CCCCCCCCCCCCCCC	38.98	46160927
306	Phosphorylation	QEDATQETHISSPVE CCCCCCCCCCCCCCC	18.07	28348404
309	Phosphorylation	ATQETHISSPVESPS CCCCCCCCCCCCCCC	22.45	28348404
310	Phosphorylation	TQETHISSPVESPSQ CCCCCCCCCCCCCCC	32.15	28348404
314	Phosphorylation	HISSPVESPSQKTKS CCCCCCCCCCCCCCC	30.04	28348404
325	Phosphorylation	KTKSETVTGELSKLL CCCCHHHHHHHHHHH	32.15	46160933
353	Phosphorylation	EDLCHTISDHYLDNL HHHHHHHHHHHHHHH	21.35	24076635
364	Phosphorylation	LDNLSKISEEELGKN HHHHHHCCHHHHCCC	42.57	-
389 (in isoform 2)	Phosphorylation	-	16.19	27251275
413 (in isoform 5)	Phosphorylation	-	20.62	27251275
426	Phosphorylation	FPMLAQESYPKKRNY CCCCCCCCCCCCCCE	34.35	24719451
473 (in isoform 3)	Phosphorylation	-	53.33	27251275
488	Phosphorylation	NASEVAVTTPGTSNH CCCCEEEECCCCCCC	19.96	27251275
489	Phosphorylation	ASEVAVTTPGTSNHR CCCEEEECCCCCCCC	17.08	27251275
498	Phosphorylation	GTSNHRNSSTGPTPD CCCCCCCCCCCCCCC	29.27	30301811
499	Phosphorylation	TSNHRNSSTGPTPDC CCCCCCCCCCCCCCC	40.72	30301811
500	Phosphorylation	SNHRNSSTGPTPDCS CCCCCCCCCCCCCCC	47.18	30301811
503	Phosphorylation	RNSSTGPTPDCSPPS CCCCCCCCCCCCCCC	32.86	24076635
507	Phosphorylation	TGPTPDCSPPSPDTA CCCCCCCCCCCHHHH	47.42	24076635
510	Phosphorylation	TPDCSPPSPDTALKN CCCCCCCCHHHHHHH	38.50	30301811
513	Phosphorylation	CSPPSPDTALKNIVK CCCCCHHHHHHHHHH	36.96	30301811
520	Ubiquitination	TALKNIVKVIRPQPK HHHHHHHHHHCCCCC	28.31	-
530	Phosphorylation	RPQPKQRTSIVSSLD CCCCCCCCEEEEEEE	21.95	27251275
531	Phosphorylation	PQPKQRTSIVSSLDF CCCCCCCEEEEEEEH	24.15	28348404
644	Phosphorylation	DEVSLANSPLPFKQS CCCCCCCCCCCCCCC	23.39	113324071
651	Phosphorylation	SPLPFKQSPIENNSE CCCCCCCCCCCCCCC	28.56	24076635
678	Phosphorylation	RTIFHKKSNQLENHT EEEEECCCCCCCCCE	34.31	24719451
689	Phosphorylation	ENHTIVGTRSTRSGS CCCEEEEECCCCCCC	15.56	46160939
721	Phosphorylation	CTLGRIRSLPKALID HHHHHHHHHHHHHHH	46.80	24719451
734	Phosphorylation	IDMHLSKSVSKSDSD HHHHHCCCCCCCHHC	28.39	25307156
736	Phosphorylation	MHLSKSVSKSDSDLI HHHCCCCCCCHHCCE	33.27	30301811
738	Phosphorylation	LSKSVSKSDSDLIAY HCCCCCCCHHCCEEE	34.54	25850435
740	Phosphorylation	KSVSKSDSDLIAYPS CCCCCCHHCCEEECC	41.21	30301811
745	Phosphorylation	SDSDLIAYPSNEKTS CHHCCEEECCCCCCC	10.53	25850435
747	Phosphorylation	SDLIAYPSNEKTSRV HCCEEECCCCCCCCC	44.97	102780265
773	Phosphorylation	SKGNSERTPSFTSEW CCCCCCCCCCCCCCH	21.16	-
775	Phosphorylation	GNSERTPSFTSEWEE CCCCCCCCCCCCHHH	40.31	73404909
887	Phosphorylation	GHDGYHPTSVAEWLD CCCCCCCCCHHHHHH	23.63	26434552
895	Phosphorylation	SVAEWLDSIELGDYT CHHHHHHHCCCCCCC	18.78	26434552
901	Phosphorylation	DSIELGDYTKAFLIN HHCCCCCCCEEEEEC	14.35	26434552
942	Phosphorylation	HRKRILASLGDRLHD HHHHHHHHHHHHHCC	29.46	46160915
974	Phosphorylation	NHTPPQLSPSLSQST CCCCCCCCCCCCCCC	13.75	-
1007	Phosphorylation	RRRRNENYFDDIPRS HHHCCCCCCCCCCHH	11.38	27196784
1030	Phosphorylation	TGDWGEPSITLRPPN HCCCCCCCCEECCCC	24.73	24719451
1032	Phosphorylation	DWGEPSITLRPPNEA CCCCCCCEECCCCCC	22.50	24719451
1078	Phosphorylation	LIKELRGTESTQDAC HHHHHHCCCCHHHHH	21.96	50564235
1080	Phosphorylation	KELRGTESTQDACAK HHHHCCCCHHHHHHH	31.07	50564243
1081	Phosphorylation	ELRGTESTQDACAKM HHHCCCCHHHHHHHH	25.00	50564251
1096	O-linked_Glycosylation	RANCQKSTEQMKKVP HHHHHHCHHHHHCCC	36.95	30379171
1104	Phosphorylation	EQMKKVPTIILSVSY HHHHCCCEEEEEEEC	24.52	46160921
1223	Phosphorylation	PRVSIRKSVDLLHAS CCCEEHHHHHHHHHH	15.83	26670566

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANS1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANS1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANS1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	20100865
A4_HUMAN	APP	physical	21832049
EPHA8_HUMAN	EPHA8	physical	20100865

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.