LR2BP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LR2BP_HUMAN
• UniProt AC: Q9P2M1
• Protein Name: LRP2-binding protein
• Gene Name: LRP2BP
• Organism: Homo sapiens (Human).
• Sequence Length: 347
• Subcellular Localization: Cytoplasm . Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
• Protein Description: May act as an adapter that regulates LRP2 function..
• Protein Sequence: MKLTSEKLPKNPFYASVSQYAAKNQKFFQWKKEKTDYTHANLVDKALQLLKERILKGDTLAYFLRGQLYFEEGWYEEALEQFEEIKEKDHQATYQLGVMYYDGLGTTLDAEKGVDYMKKILDSPCPKARHLKFAAAYNLGRAYYEGKGVKRSNEEAERLWLIAADNGNPKASVKAQSMLGLYYSTKEPKELEKAFYWHSEACGNGNLESQGALGLMYLYGQGIRQDTEAALQCLREAAERGNVYAQGNLVEYYYKMKFFTKCVAFSKRIADYDEVHDIPMIAQVTDCLPEFIGRGMAMASFYHARCLQLGLGITRDETTAKHYYSKACRLNPALADELHSLLIRQRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	WKKEKTDYTHANLVD CHHCCCCCCHHHHHH	12.98	17287340
51	2-Hydroxyisobutyrylation	DKALQLLKERILKGD HHHHHHHHHHHHCCC	54.24	-
182	Phosphorylation	AQSMLGLYYSTKEPK HHHHHCHHCCCCCHH	8.12	-
183	Phosphorylation	QSMLGLYYSTKEPKE HHHHCHHCCCCCHHH	18.20	-
184	Phosphorylation	SMLGLYYSTKEPKEL HHHCHHCCCCCHHHH	21.32	-
285	Phosphorylation	IPMIAQVTDCLPEFI CCHHHHHHHHCHHHH	14.65	22210691
300	Phosphorylation	GRGMAMASFYHARCL CHHHHHHHHHHHHHH	17.16	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LR2BP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LR2BP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LR2BP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP2_HUMAN	LRP2	physical	12508107
GSTT1_HUMAN	GSTT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-37, AND MASSSPECTROMETRY.
PubMed: 17287340