PKHS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHS1_HUMAN
• UniProt AC: Q5SXH7
• Protein Name: Pleckstrin homology domain-containing family S member 1
• Gene Name: PLEKHS1
• Organism: Homo sapiens (Human).
• Sequence Length: 462
• Protein Sequence: MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHHHRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDWVSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHLMEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIASSDSGESIETDGPDQVSGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADVEAQTTNDQKGSASLTVVQLSILINNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCHGDHLLAVNDLKPQSLEEVSLFLTRSIQKEKLKLTIGRIPNSETFHAASCMCPSKCQSAAPSQLDKPRLNRAPKRSPAIKKSQQKGARE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 4)	Phosphorylation	-		22617229
8	Phosphorylation	MAGGKQFTFSYENEV CCCCCEEEEEECCCC		24719451
24	Phosphorylation	KQDYFIKSPPSQLFS CCCEEECCCHHHHHH		28348404
27	Phosphorylation	YFIKSPPSQLFSSVT EEECCCHHHHHHCCC		28348404
31	Phosphorylation	SPPSQLFSSVTSWKK CCHHHHHHCCCHHHE		25003641
32	Phosphorylation	PPSQLFSSVTSWKKR CHHHHHHCCCHHHEE		25003641
34	Phosphorylation	SQLFSSVTSWKKRFF HHHHHCCCHHHEEEE		25003641
50	Phosphorylation	LSKAGEKSFSLSYYK EECCCCCEEEEEEEC		27251275
52	Phosphorylation	KAGEKSFSLSYYKDH CCCCCEEEEEEECCC		27251275
64	Phosphorylation	KDHHHRGSIEIDQNS CCCCCCCCEEECCCC		25850435
71	Phosphorylation	SIEIDQNSSVEVGIS CEEECCCCEEEECCC		25850435
72	Phosphorylation	IEIDQNSSVEVGISS EEECCCCEEEECCCC		25850435
78	Phosphorylation	SSVEVGISSQEKMQS CEEEECCCCHHHHHH		25850435
79	Phosphorylation	SVEVGISSQEKMQSV EEEECCCCHHHHHHH		25850435
102	Phosphorylation	DEVMSIRTTNREYFL HHCEEEEECCCEEEE		28152594
103	Phosphorylation	EVMSIRTTNREYFLI HCEEEEECCCEEEEE		28152594
107	Phosphorylation	IRTTNREYFLIGHDR EEECCCEEEEEECCH		28152594
143	Phosphorylation	QNTEEELSLGNKRTL CCCHHHHHCCCCCEE		27251275
149	Phosphorylation	LSLGNKRTLFYSSPL HHCCCCCEEEEECCC		-
153	Phosphorylation	NKRTLFYSSPLLGPS CCCEEEEECCCCCCC		24719451
154	Phosphorylation	KRTLFYSSPLLGPSS CCEEEEECCCCCCCC		27251275
159	Phosphorylation	YSSPLLGPSSTSEAV EECCCCCCCCCCCCC		24719451
160	Phosphorylation	SSPLLGPSSTSEAVG ECCCCCCCCCCCCCC		28348404
161	Phosphorylation	SPLLGPSSTSEAVGS CCCCCCCCCCCCCCC		28348404
162	Phosphorylation	PLLGPSSTSEAVGSS CCCCCCCCCCCCCCC		28348404
163	Phosphorylation	LLGPSSTSEAVGSSS CCCCCCCCCCCCCCC		28348404
168	Phosphorylation	STSEAVGSSSPRNGL CCCCCCCCCCCCCCC		26657352
169	Phosphorylation	TSEAVGSSSPRNGLQ CCCCCCCCCCCCCCC		29802988
170	Phosphorylation	SEAVGSSSPRNGLQD CCCCCCCCCCCCCCC		27966365
176	Phosphorylation	SSPRNGLQDKHLMEQ CCCCCCCCCHHHHHH		24719451
184	Phosphorylation	DKHLMEQSSPGFRQT CHHHHHHCCCCCCHH		22617229
185	Phosphorylation	KHLMEQSSPGFRQTH HHHHHHCCCCCCHHH		22617229
191	Phosphorylation	SSPGFRQTHLQDLSE CCCCCCHHHHHHHHH		24719451
200	Phosphorylation	LQDLSEATQDVKEEN HHHHHHHHHHHHHHC		26356563
209	Phosphorylation	DVKEENHYLTPRSVL HHHHHCCCCCHHHHH		26356563
211	Phosphorylation	KEENHYLTPRSVLLE HHHCCCCCHHHHHHE		26356563
217	Phosphorylation	LTPRSVLLELDNIIA CCHHHHHHEECCEEE		24719451
248	Phosphorylation	SGRIECHYEPMESSF CCEEEEECCCCCCCC		26356563
253	Phosphorylation	CHYEPMESSFFKETS EECCCCCCCCCEECC		23401153
260	Phosphorylation	SSFFKETSHESVDSS CCCCEECCCCCCCCC		-
263	Phosphorylation	FKETSHESVDSSKEE CEECCCCCCCCCCCC		30576142
266	Phosphorylation	TSHESVDSSKEEPQT CCCCCCCCCCCCCCC		30576142
312	Phosphorylation	TNDQKGSASLTVVQL CCCCCCCEEEEEEEH		24719451
339	Phosphorylation	VEKLNVFLSPPDVIN HHHCCEECCCHHHHH		27251275
340	Phosphorylation	EKLNVFLSPPDVINY HHCCEECCCHHHHHH		28348404
408	Phosphorylation	QKEKLKLTIGRIPNS HHHCCEEEEECCCCC		24719451
435	Phosphorylation	KCQSAAPSQLDKPRL HHHCCCHHHCCCCHH		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_HUMAN	GRB2	physical	25814554
P55G_HUMAN	PIK3R3	physical	25814554
PBLD_HUMAN	PBLD	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.