| UniProt ID | AUNIP_HUMAN | |
|---|---|---|
| UniProt AC | Q9H7T9 | |
| Protein Name | Aurora kinase A and ninein-interacting protein {ECO:0000303|PubMed:20596670} | |
| Gene Name | AUNIP {ECO:0000303|PubMed:29042561, ECO:0000312|HGNC:HGNC:28363} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 357 | |
| Subcellular Localization | Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replicatio | |
| Protein Description | DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. [PubMed: 29042561 Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair] | |
| Protein Sequence | MRRTGPEEEACGVWLDAAALKRRKVQTHLIKPGTKMLTLLPGERKANIYFTQRRAPSTGIHQRSIASFFTLQPGKTNGSDQKSVSSHTESQINKESKKNATQLDHLIPGLAHDCMASPLATSTTADIQEAGLSPQSLQTSGHHRMKTPFSTELSLLQPDTPDCAGDSHTPLAFSFTEDLESSCLLDRKEEKGDSARKWEWLHESKKNYQSMEKHTKLPGDKCCQPLGKTKLERKVSAKENRQAPVLLQTYRESWNGENIESVKQSRSPVSVFSWDNEKNDKDSWSQLFTEDSQGQRVIAHNTRAPFQDVTNNWNWDLGPFPNSPWAQCQEDGPTQNLKPDLLFTQDSEGNQVIRHQF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 27 | Phosphorylation | LKRRKVQTHLIKPGT HHHCCCHHEEECCCC | - | ||
| 34 | Phosphorylation | THLIKPGTKMLTLLP HEEECCCCEEEEECC | - | ||
| 38 | Phosphorylation | KPGTKMLTLLPGERK CCCCEEEEECCCCHH | - | ||
| 49 | Phosphorylation | GERKANIYFTQRRAP CCHHCEEEEECCCCC | - | ||
| 236 | Phosphorylation | TKLERKVSAKENRQA CHHHHHCCHHHHCCC | 24719451 | ||
| 263 | Ubiquitination | GENIESVKQSRSPVS CCCHHHHHHCCCCCE | 29967540 | ||
| 265 | Phosphorylation | NIESVKQSRSPVSVF CHHHHHHCCCCCEEE | 22199227 | ||
| 267 | Phosphorylation | ESVKQSRSPVSVFSW HHHHHCCCCCEEEEE | 25159151 | ||
| 270 | Phosphorylation | KQSRSPVSVFSWDNE HHCCCCCEEEEECCC | 22199227 | ||
| 273 | Phosphorylation | RSPVSVFSWDNEKND CCCCEEEEECCCCCC | 22199227 | ||
| 281 | Ubiquitination | WDNEKNDKDSWSQLF ECCCCCCCCCHHHHH | 29967540 | ||
| 289 | Phosphorylation | DSWSQLFTEDSQGQR CCHHHHHEECCCCCE | 23186163 | ||
| 292 | Phosphorylation | SQLFTEDSQGQRVIA HHHHEECCCCCEEEE | 17525332 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AUNIP_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AUNIP_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AUNIP_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ANM6_HUMAN | PRMT6 | physical | 23455924 | |
| TRI68_HUMAN | TRIM68 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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