PPIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIP2_HUMAN
• UniProt AC: Q9H939
• Protein Name: Proline-serine-threonine phosphatase-interacting protein 2
• Gene Name: PSTPIP2
• Organism: Homo sapiens (Human).
• Sequence Length: 334
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity)..
• Protein Sequence: MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLSRKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKTELIMDAIHKQKSLQFKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKLATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQLSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYENFYSSQKNAVPAGKATGPNLARRGPLPIPKSSPDDPNYSLVDDYSLLYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MTRSLFKGNFW ----CCCCCCCCCCC	29.05	24719451
36	Ubiquitination	NNGRKNCKEFEDFLK HHCCCCHHHHHHHHH	74.88	-
68	Phosphorylation	RKKPCGQSEINTLKR CCCCCCHHHHHHHHH	26.23	22210691
117	Acetylation	EKQKLQRKKTELIMD HHHHHHHHHHHHHHH	51.60	7976115
118	Acetylation	KQKLQRKKTELIMDA HHHHHHHHHHHHHHH	49.79	7976127
119	O-linked_Glycosylation	QKLQRKKTELIMDAI HHHHHHHHHHHHHHH	38.77	30379171
128	Acetylation	LIMDAIHKQKSLQFK HHHHHHHHHHCHHHH	53.99	7976139
136	Acetylation	QKSLQFKKTMDAKKN HHCHHHHHHHHHHHH	50.82	7966179
137	Phosphorylation	KSLQFKKTMDAKKNY HCHHHHHHHHHHHHH	22.37	-
141	Acetylation	FKKTMDAKKNYEQKC HHHHHHHHHHHHHHH	36.97	15614425
176	Ubiquitination	QQEKLFVKLATSKTA HHHHHHHHHHCCCCC	25.68	-
181 (in isoform 2)	Ubiquitination	-	35.83	21906983
181 (in isoform 1)	Ubiquitination	-	35.83	21906983
181	Ubiquitination	FVKLATSKTAVEDSD HHHHHCCCCCCCCCC	35.83	2190698
267	Phosphorylation	SIQRDIEYFVNQRKT HCHHHHHHHHHCCCC	17.11	21552520
274	Phosphorylation	YFVNQRKTGQIPPAP HHHHCCCCCCCCCCC	36.19	29759185
288	Phosphorylation	PIMYENFYSSQKNAV CCCCCCCCCCCCCCC	20.99	27642862
289	Phosphorylation	IMYENFYSSQKNAVP CCCCCCCCCCCCCCC	23.35	18077418
290	Phosphorylation	MYENFYSSQKNAVPA CCCCCCCCCCCCCCC	33.52	29759185
292	Acetylation	ENFYSSQKNAVPAGK CCCCCCCCCCCCCCC	49.15	7661935
299	Ubiquitination	KNAVPAGKATGPNLA CCCCCCCCCCCCCHH	44.90	-
299	Acetylation	KNAVPAGKATGPNLA CCCCCCCCCCCCCHH	44.90	7661943
301	Phosphorylation	AVPAGKATGPNLARR CCCCCCCCCCCHHHC	57.57	18785766
311 (in isoform 2)	Phosphorylation	-	7.18	-
316	Phosphorylation	GPLPIPKSSPDDPNY CCCCCCCCCCCCCCC	41.57	28450419
317	Phosphorylation	PLPIPKSSPDDPNYS CCCCCCCCCCCCCCC	38.17	28450419
323	Phosphorylation	SSPDDPNYSLVDDYS CCCCCCCCCCCCCCH	14.58	28450419
324	Phosphorylation	SPDDPNYSLVDDYSL CCCCCCCCCCCCCHH	28.67	28450419
329	Phosphorylation	NYSLVDDYSLLYQ-- CCCCCCCCHHHCC--	9.21	-
333	Phosphorylation	VDDYSLLYQ------ CCCCHHHCC------	19.92	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PPIP2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.