GARE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GARE2_HUMAN
• UniProt AC: Q75VX8
• Protein Name: GRB2-associated and regulator of MAPK protein 2
• Gene Name: GAREM2
• Organism: Homo sapiens (Human).
• Sequence Length: 874
• Protein Description: Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway..
• Protein Sequence: MEKLAAGLAGLRWSMGAFPLDLIVSRCRLPTLACLGPGEYAEGVSERDILLIHSCRQWTTVTAHTLEEGHYVIGPKIDIPLQYPGKFKLLEQARDVREPVRYFSSVEEVASVFPDRIFVMEAITFSVKVVSGEFSEDSEVYNFTLHAGDELTLMGQAEILCAKTTKERSRFTTLLRKLGRAGALAGVGGGGPASAGAAGGTGGGGARPVKGKMPCLICMNHRTNESLSLPFQCQGRFSTRSPLELQMQEGEHTVRAIIERVRLPVNVLVPSRPPRNPYDLHPVREGHCYKLVSIISKTVVLGLALRREGPAPLHFLLLTDTPRFALPQGLLAGDPRVERLVRDSASYCRERFDPDEYSTAVREAPAELAEDCASPRRARLCLPAPRAPGLARAPGPLAPAPAGEGDQEYVSPDWAAAPEPAAPPAEIPYEELWAHQGPEGLVRPPPGLDLISFGAAGPPRREPEAPPPPVPPKSEAVKEECRLLNAPPVPPRGGNGSGRLSSSPPVPPRFPKLQPVHSPSSSLSYYSSGLQDGAGSRSGSGSPSPDTYSLYCYPCTWGDCKVGESSSRPAPGPLPSTTQPSQASRALTEPLSGRAASLLGADTPVKTYHSCPPLFKPSHPQKRFAPFGALNPFSGPAYPSGPSAALSSGPRTTSGPVATSGPAYSPGPASPGQAYSAAPPSSCAPSSSSSSEWQEPVLEPFDPFELGQGSSPEPELLRSQEPRAVGTPGPGPRLSPLGPSKAFEPEGLVLHQVPTPLSPAALQGPEAGGALFLTQGRLEGPPASPRDGATGFGVRDASSWQPPADLSALSLEEVSRSLRFIGLSEDVVSFFARERIDGSIFVQLSEDILADDFHLTKLQVKKIMQFIKGWRPKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	FPLDLIVSRCRLPTL CCHHHHHCCCCCCCE		24719451
102	Phosphorylation	DVREPVRYFSSVEEV CCCCCHHHCCCHHHH		-
104	Phosphorylation	REPVRYFSSVEEVAS CCCHHHCCCHHHHHH		-
124	Phosphorylation	IFVMEAITFSVKVVS EEEEEEEEEEEEEEE		-
126	Phosphorylation	VMEAITFSVKVVSGE EEEEEEEEEEEEECC		-
169	Phosphorylation	AKTTKERSRFTTLLR ECCHHHHHHHHHHHH		25072903
172	Phosphorylation	TKERSRFTTLLRKLG HHHHHHHHHHHHHHH		25072903
173	Phosphorylation	KERSRFTTLLRKLGR HHHHHHHHHHHHHHH		24260401
201	Phosphorylation	SAGAAGGTGGGGARP CCCCCCCCCCCCCCC		22210691
293	Phosphorylation	GHCYKLVSIISKTVV CCHHHHHHHHHHHHH		24719451
374	Phosphorylation	ELAEDCASPRRARLC HHHHHCCCCCCEEEC		27732954
429	Phosphorylation	APPAEIPYEELWAHQ CCCCCCCHHHHHHHC		-
501	Phosphorylation	GNGSGRLSSSPPVPP CCCCCCCCCCCCCCC		23312004
502	Phosphorylation	NGSGRLSSSPPVPPR CCCCCCCCCCCCCCC		23312004
525	Phosphorylation	SPSSSLSYYSSGLQD CCCCCCHHHCCCCCC		32142685
548	Phosphorylation	GSPSPDTYSLYCYPC CCCCCCCEEEEEEEC		-
551	Phosphorylation	SPDTYSLYCYPCTWG CCCCEEEEEEECCCC		-
588	Phosphorylation	SQASRALTEPLSGRA HHHHHHHCCCCCHHH		28509920
603	Phosphorylation	ASLLGADTPVKTYHS HHHHCCCCCCCCCCC		28509920
727	Phosphorylation	QEPRAVGTPGPGPRL CCCCCCCCCCCCCCC		-
735	Phosphorylation	PGPGPRLSPLGPSKA CCCCCCCCCCCCCCC		30266825
740	Phosphorylation	RLSPLGPSKAFEPEG CCCCCCCCCCCCCCC		30266825
784	Phosphorylation	RLEGPPASPRDGATG CCCCCCCCCCCCCCC		23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GARE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GARE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GARE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECM29_HUMAN	KIAA0368	physical	20682791
GRB2_HUMAN	GRB2	physical	24003223
PTN11_HUMAN	PTPN11	physical	24003223

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.