GAB3_HUMAN - dbPTM
GAB3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAB3_HUMAN
UniProt AC Q8WWW8
Protein Name GRB2-associated-binding protein 3
Gene Name GAB3
Organism Homo sapiens (Human).
Sequence Length 586
Subcellular Localization
Protein Description
Protein Sequence MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCHGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSGSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47PhosphorylationGNPDVLEYYRNKHSS
CCHHHHHHHHHCCCC		11.9923917254
94PhosphorylationIVKTTSRTFYLVAKT
EEEECCCEEEEEEEC		19.1929759185
96PhosphorylationKTTSRTFYLVAKTEQ
EECCCEEEEEEECHH		10.3129759185
153PhosphorylationLLTAHAASSSLPRDD
HHHHHHHHCCCCCCC		22.6526699800
154PhosphorylationLTAHAASSSLPRDDP
HHHHHHHCCCCCCCC		31.0326699800
155PhosphorylationTAHAASSSLPRDDPN
HHHHHHCCCCCCCCC		39.6424719451
163PhosphorylationLPRDDPNTNAVATEE
CCCCCCCCCCCCCCC		29.9128450419
168PhosphorylationPNTNAVATEETRSES
CCCCCCCCCCCCCHH		27.9628450419
171PhosphorylationNAVATEETRSESELL
CCCCCCCCCCHHHEE		33.0128450419
173PhosphorylationVATEETRSESELLFL
CCCCCCCCHHHEEEC		53.5528450419
175PhosphorylationTEETRSESELLFLPD
CCCCCCHHHEEECCC		34.4928450419
197PhosphorylationETGRLHHTSLPTRCD
CCCCCCCCCCCCCCC		22.6321722762
198PhosphorylationTGRLHHTSLPTRCDS
CCCCCCCCCCCCCCC		28.1721722762
205PhosphorylationSLPTRCDSWSNSDRS
CCCCCCCCCCCCCCC		35.7121722762
207PhosphorylationPTRCDSWSNSDRSLE
CCCCCCCCCCCCCHH		30.3321722762
231PhosphorylationDCLQPLPSSHLVHPS
HCCCCCCHHHCCCCC		37.7626074081
232PhosphorylationCLQPLPSSHLVHPSC
CCCCCCHHHCCCCCC		20.9226074081
238PhosphorylationSSHLVHPSCHGSGAQ
HHHCCCCCCCCCCCC		12.1326074081
242PhosphorylationVHPSCHGSGAQEVPS
CCCCCCCCCCCCCCC		13.8026074081
249PhosphorylationSGAQEVPSSRPQAAL
CCCCCCCCCCCCEEE		44.1226074081
250PhosphorylationGAQEVPSSRPQAALI
CCCCCCCCCCCEEEE		41.7426074081
271PhosphorylationGPPRDHLSSSPLLES
CCCCCCCCCCHHHHH		25.9127080861
272PhosphorylationPPRDHLSSSPLLESS
CCCCCCCCCHHHHHH		42.1927080861
273PhosphorylationPRDHLSSSPLLESSL
CCCCCCCCHHHHHHH		19.0527080861
278PhosphorylationSSSPLLESSLSSTIQ
CCCHHHHHHHCCCEE		36.2327080861
279PhosphorylationSSPLLESSLSSTIQV
CCHHHHHHHCCCEEE		23.9327080861
283PhosphorylationLESSLSSTIQVDKNQ
HHHHHCCCEEECCCC		16.44-
344PhosphorylationTLVPRRISLSGLDNM
EEECCEEECCCCCCC		18.0523401153
345PhosphorylationLVPRRISLSGLDNMR
EECCEEECCCCCCCC		4.3524719451
346PhosphorylationVPRRISLSGLDNMRT
ECCEEECCCCCCCCC		30.4423927012
355UbiquitinationLDNMRTWKADVEGQS
CCCCCCEECCCCCCC		33.8129967540
356UbiquitinationDNMRTWKADVEGQSL
CCCCCEECCCCCCCC		20.04-
356UbiquitinationDNMRTWKADVEGQSL
CCCCCEECCCCCCCC		20.0429967540
362PhosphorylationKADVEGQSLRHRDKR
ECCCCCCCCCCCCCC		37.9221722762
371PhosphorylationRHRDKRLSLNLPCRF
CCCCCCCCCCCCCCC		21.1723401153
372PhosphorylationHRDKRLSLNLPCRFS
CCCCCCCCCCCCCCC		10.1224719451
397PhosphorylationEDSYVPMSPQAGASG
CCCCCCCCCCCCCCC		14.0626074081
466PhosphorylationSIIREHASLTRTRTV
HHHHHHHCCCCCEEE		31.9821722762
468PhosphorylationIREHASLTRTRTVPC
HHHHHCCCCCEEEEC		27.7421722762
478PhosphorylationRTVPCSRTSFLSPER
EEEECCCCCCCCCCC		13.9223186163
479PhosphorylationTVPCSRTSFLSPERN
EEECCCCCCCCCCCC		24.0723186163
482PhosphorylationCSRTSFLSPERNGIN
CCCCCCCCCCCCCCC		23.7823401153
483PhosphorylationSRTSFLSPERNGINS
CCCCCCCCCCCCCCC		46.8724719451
499PhosphorylationRFFANPVSREDEESY
HHCCCCCCCCCHHHH		31.0729978859
505PhosphorylationVSREDEESYIEMEEH
CCCCCHHHHCCHHHH		29.3921722762
506 (in isoform 3)Phosphorylation-12.2725159151
506PhosphorylationSREDEESYIEMEEHR
CCCCHHHHCCHHHHH		12.2724927040
507PhosphorylationREDEESYIEMEEHRT
CCCHHHHCCHHHHHC		5.9027642862
507 (in isoform 3)Phosphorylation-5.9025159151
514PhosphorylationIEMEEHRTASSLSSG
CCHHHHHCCHHHCCC		32.5722817900
517PhosphorylationEEHRTASSLSSGALT
HHHHCCHHHCCCCCH		29.79-
519PhosphorylationHRTASSLSSGALTWT
HHCCHHHCCCCCHHE		28.7722817900
530PhosphorylationLTWTKKFSLDYLALD
CHHEEEEECEEEEEC		29.2522210691
533PhosphorylationTKKFSLDYLALDFNS
EEEEECEEEEECCCC		10.1217360941
537UbiquitinationSLDYLALDFNSASPA
ECEEEEECCCCCCCC		34.7729967540
537UbiquitinationSLDYLALDFNSASPA
ECEEEEECCCCCCCC		34.77-
540PhosphorylationYLALDFNSASPAPMQ
EEEECCCCCCCCHHH		30.0722210691
542PhosphorylationALDFNSASPAPMQQK
EECCCCCCCCHHHHH		22.7822210691
553PhosphorylationMQQKLLLSEEQRVDY
HHHHHHCCHHHCCCE		38.7722210691
560PhosphorylationSEEQRVDYVQVDEQK
CHHHCCCEEECCHHH		7.0223401153
561PhosphorylationEEQRVDYVQVDEQKT
HHHCCCEEECCHHHH		3.7527642862
575UbiquitinationTQALQSTKQEWTDER
HHHHHHHHHHHHHHH		52.0129967540
576UbiquitinationQALQSTKQEWTDERQ
HHHHHHHHHHHHHHH		52.1029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GAB3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAB3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAB3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PTN11_HUMANPTPN11physical
11739737
GRB2_HUMANGRB2physical
11739737
ABL1_HUMANABL1physical
18235045
LYN_HUMANLYNphysical
18235045
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAB3_HUMAN

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Related Literatures of Post-Translational Modification

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