HUNK_HUMAN - dbPTM
HUNK_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HUNK_HUMAN
UniProt AC P57058
Protein Name Hormonally up-regulated neu tumor-associated kinase
Gene Name HUNK
Organism Homo sapiens (Human).
Sequence Length 714
Subcellular Localization
Protein Description
Protein Sequence MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56UbiquitinationLRDFQHHKRVGNYLI
HHHHHHHHCCCCEEE		46.8029967540
65PhosphorylationVGNYLIGSRKLGEGS
CCCEEEECEECCCCC		21.17-
67UbiquitinationNYLIGSRKLGEGSFA
CEEEECEECCCCCCC		63.6429967540
75UbiquitinationLGEGSFAKVREGLHV
CCCCCCCHHHCCEEE		39.5529967540
91UbiquitinationTGEKVAIKVIDKKRA
CCCEEEEEEECHHHC		24.33-
106UbiquitinationKKDTYVTKNLRREGQ
CCCCCCCHHHHHHHH		43.89-
188UbiquitinationGVVHRDLKIENLLLD
CCCCCCCCCHHEEEC		52.87-
248PhosphorylationGPKIDVWSIGVNMYA
CCCCCEEEEECHHHH		14.8722210691
254PhosphorylationWSIGVNMYAMLTGTL
EEEECHHHHHHHCCC		5.4422210691
258PhosphorylationVNMYAMLTGTLPFTV
CHHHHHHHCCCCCEE		18.2922210691
260PhosphorylationMYAMLTGTLPFTVEP
HHHHHHCCCCCEECC		26.4822210691
274PhosphorylationPFSLRALYQKMVDKE
CCCHHHHHHHHHCCC		12.7122210691
307UbiquitinationLLEPDPVKRPNIQQA
HHCCCCCCCCCHHHH		68.47-
327UbiquitinationLNENYTGKVPCNVTY
HCCCCCCCCCCCCCC		34.89-
333PhosphorylationGKVPCNVTYPNRISL
CCCCCCCCCCCCCCH		21.1926074081
334PhosphorylationKVPCNVTYPNRISLE
CCCCCCCCCCCCCHH		8.3326074081
339PhosphorylationVTYPNRISLEDLSPS
CCCCCCCCHHHCCHH		23.5926074081
344PhosphorylationRISLEDLSPSVVLHM
CCCHHHCCHHHHHHH		27.7026074081
346PhosphorylationSLEDLSPSVVLHMTE
CHHHCCHHHHHHHHH		22.8326074081
352PhosphorylationPSVVLHMTEKLGYKN
HHHHHHHHHHHCCCC		21.1526074081
360PhosphorylationEKLGYKNSDVINTVL
HHHCCCCHHHHHHHH		29.15-
365O-linked_GlycosylationKNSDVINTVLSNRAC
CCHHHHHHHHHHHHH		16.23OGP
368PhosphorylationDVINTVLSNRACHIL
HHHHHHHHHHHHHHH		21.67-
378PhosphorylationACHILAIYFLLNKKL
HHHHHHHHHHHHHHH		5.20-
388PhosphorylationLNKKLERYLSGKSDI
HHHHHHHHHCCCCCC		8.8822817900
390PhosphorylationKKLERYLSGKSDIQD
HHHHHHHCCCCCCCC		34.9328258704
392UbiquitinationLERYLSGKSDIQDSL
HHHHHCCCCCCCCCH		41.3929967540
402UbiquitinationIQDSLCYKTRLYQIE
CCCCHHHHHCHHHHH		26.6029967540
406PhosphorylationLCYKTRLYQIEKYRA
HHHHHCHHHHHCCCC		12.2622817900
454PhosphorylationDFLHRPFSKKLDKNL
CCCCCHHHHHCCCCC		31.4029449344
467UbiquitinationNLPSHKQPSGSLMTQ
CCCCCCCCCCCHHHH		45.5217203973
483UbiquitinationQNTKALLKDRKASKS
HHHHHHHHCHHHHHC		57.2317203973
488PhosphorylationLLKDRKASKSSFPDK
HHHCHHHHHCCCCCC		35.7825072903
490PhosphorylationKDRKASKSSFPDKDS
HCHHHHHCCCCCCCC		34.4125072903
491PhosphorylationDRKASKSSFPDKDSF
CHHHHHCCCCCCCCC		44.5325072903
507PhosphorylationCRNIFRKTSDSNCVA
CHHHHHCCCCCCCEE		33.2527732954
508PhosphorylationRNIFRKTSDSNCVAS
HHHHHCCCCCCCEEC		41.9227732954
510PhosphorylationIFRKTSDSNCVASSS
HHHCCCCCCCEECCC		31.7127732954
515PhosphorylationSDSNCVASSSMEFIP
CCCCCEECCCCCEEC		11.5327732954
516PhosphorylationDSNCVASSSMEFIPV
CCCCEECCCCCEECC		24.7827732954
517PhosphorylationSNCVASSSMEFIPVP
CCCEECCCCCEECCC		21.6027732954
561PhosphorylationLMLDMVRSFESVDRD
CHHHHHHHHCCCCCC		23.1925841592
564PhosphorylationDMVRSFESVDRDDHV
HHHHHHCCCCCCCCE		27.5725841592
585PhosphorylationHHYRILNSPVSLARR
HHHHHHCCCHHHHCC		24.1922617229
588PhosphorylationRILNSPVSLARRNSS
HHHCCCHHHHCCCCC		21.5028857561
618PhosphorylationLHTPLHPTLVSFAHE
CCCCCCCHHHHHHCC		29.10-
674AcetylationGIGQMLRKRHQSLQP
HHHHHHHHHHHHCCC		50.7168917
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HUNK_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HUNK_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HUNK_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of HUNK_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HUNK_HUMAN

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"The proteomic reactor facilitates the analysis of affinity-purifiedproteins by mass spectrometry: application for identifyingubiquitinated proteins in human cells.";
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M.,Haines D.S., Figeys D.;
J. Proteome Res. 6:298-305(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-483, AND MASSSPECTROMETRY.

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