KRT83_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRT83_HUMAN
• UniProt AC: P78385
• Protein Name: Keratin, type II cuticular Hb3
• Gene Name: KRT83
• Organism: Homo sapiens (Human).
• Sequence Length: 493
• Protein Sequence: MTCGFNSIGCGFRPGNFSCVSACGPRPSRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFAGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRILQSHISDTSVVVKLDNSRDLNMDCIVAEIKAQYDDIATRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVEAVNVCVSSSRGGVVCGDLCVSGSRPVTGSVCSAPCNGNLVVSTGLCKPCGQLNTTCGGGSCGQGRH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	ISCYRGLTGGFGSHS CCCCCCCCCCCCCCC	37.78	20068231
52	Phosphorylation	GLTGGFGSHSVCGGF CCCCCCCCCCCCCCC	15.44	20068231
54	Phosphorylation	TGGFGSHSVCGGFRA CCCCCCCCCCCCCCC	22.32	26657352
67	Phosphorylation	RAGSCGRSFGYRSGG CCCCCCCCCCCCCCC	14.33	24719451
137	Ubiquitination	RFLEQQNKLLETKLQ HHHHHHHHHHHHHHH	50.54	22817900
142	Ubiquitination	QNKLLETKLQFYQNR HHHHHHHHHHHHHCH	30.80	22817900
208	Phosphorylation	EEVALRATAENEFVA HHHHHHHCCCCCEEE	28.24	20068231
248	Phosphorylation	IDFLRRLYEEEIRIL HHHHHHHHHHHHHHH	21.34	20071362
257	Phosphorylation	EEIRILQSHISDTSV HHHHHHHHHCCCCEE	21.24	-
263	Phosphorylation	QSHISDTSVVVKLDN HHHCCCCEEEEEECC	20.22	20068231
294	Phosphorylation	YDDIATRSRAEAESW HCHHHHHHHHHHHHH	31.33	28348404
300	Phosphorylation	RSRAEAESWYRSKCE HHHHHHHHHHHHHHH	36.13	28348404
302	Phosphorylation	RAEAESWYRSKCEEM HHHHHHHHHHHHHHH	17.81	-
310	Ubiquitination	RSKCEEMKATVIRHG HHHHHHHHHHHHHCC	44.15	33845483
312	Phosphorylation	KCEEMKATVIRHGET HHHHHHHHHHHCCHH	15.79	24719451
319	Phosphorylation	TVIRHGETLRRTKEE HHHHCCHHHHHHHHH	30.11	24719451
323	Phosphorylation	HGETLRRTKEEINEL CCHHHHHHHHHHHHH	36.05	24719451
324	Ubiquitination	GETLRRTKEEINELN CHHHHHHHHHHHHHH	52.09	33845483
345	Ubiquitination	TAEVENAKCQNSKLE HHHHHHHHHHCHHHH	48.19	33845483
350	Ubiquitination	NAKCQNSKLEAAVAQ HHHHHCHHHHHHHHC	58.87	33845483
367	Phosphorylation	QQGEAALSDARCKLA HHHHHHHHHHHHHHH	25.21	28348404
372	Ubiquitination	ALSDARCKLAELEGA HHHHHHHHHHHHHHH	45.22	-
382	Ubiquitination	ELEGALQKAKQDMAC HHHHHHHHHHHHHHH	59.40	33845483
384	Ubiquitination	EGALQKAKQDMACLI HHHHHHHHHHHHHHH	54.59	33845483
400	Phosphorylation	EYQEVMNSKLGLDIE HHHHHHHHCCCCCEE	15.91	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KRT83_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRT83_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRT83_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRT38_HUMAN	KRT38	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.