MET27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MET27_HUMAN
• UniProt AC: Q8N6F8
• Protein Name: Methyltransferase-like protein 27 {ECO:0000312|HGNC:HGNC:19068}
• Gene Name: METTL27 {ECO:0000312|HGNC:HGNC:19068}
• Organism: Homo sapiens (Human).
• Sequence Length: 245
• Protein Sequence: MAQEEGGSLPEVRARVRAAHGIPDLAQKLHFYDRWAPDYDQDVATLLYRAPRLAVDCLTQALPGPPHSALILDVACGTGLVAAELRAPGFLQLHGVDGSPGMLEQAQAPGLYQRLSLCTLGQEPLPSPEGTFDAVLIVGALSDGQVPCNAIPELHVTKPGGLVCLTTRTNSSNLQYKEALEATLDRLEQAGMWEGLVAWPVDRLWTAGSWLPPSWRWYPASLPRMASSPALSTCTESGRRPRLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	GIPDLAQKLHFYDRW CCCHHHHHHCCHHCC		21906983
214	Phosphorylation	AGSWLPPSWRWYPAS CCCCCCCCCCCCCCC		26091039
221	Phosphorylation	SWRWYPASLPRMASS CCCCCCCCCCCCCCC		24719451
227	Phosphorylation	ASLPRMASSPALSTC CCCCCCCCCCCHHHC		22210691
228	Phosphorylation	SLPRMASSPALSTCT CCCCCCCCCCHHHCC		22210691
232	Phosphorylation	MASSPALSTCTESGR CCCCCCHHHCCCCCC		22210691
233	Phosphorylation	ASSPALSTCTESGRR CCCCCHHHCCCCCCC		22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MET27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MET27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MET27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
P55G_HUMAN	PIK3R3	physical	25814554

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.