KRT35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRT35_HUMAN
• UniProt AC: Q92764
• Protein Name: Keratin, type I cuticular Ha5
• Gene Name: KRT35
• Organism: Homo sapiens (Human).
• Sequence Length: 455
• Protein Sequence: MASKCLKAGFSSGSLKSPGGASGGSTRVSAMYSSSSCKLPSLSPVARSFSACSVGLGRSSYRATSCLPALCLPAGGFATSYSGGGGWFGEGILTGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRRILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLECEINTYRGLLESEDSKLPCNPCAPDYSPSKSCLPCLPAASCGPSAARTNCSPRPICVPCPGGRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASKCLKAGF -----CCCHHHHCCC	23.70	-
29	Phosphorylation	SGGSTRVSAMYSSSS CCCCCCCEEEECCCC	12.20	-
32	Phosphorylation	STRVSAMYSSSSCKL CCCCEEEECCCCCCC	12.71	25599653
33	Phosphorylation	TRVSAMYSSSSCKLP CCCEEEECCCCCCCC	15.62	23532336
34	Phosphorylation	RVSAMYSSSSCKLPS CCEEEECCCCCCCCC	14.58	23532336
35	Phosphorylation	VSAMYSSSSCKLPSL CEEEECCCCCCCCCC	33.54	25599653
36	Phosphorylation	SAMYSSSSCKLPSLS EEEECCCCCCCCCCC	19.74	25599653
100	Phosphorylation	LTGNEKETMQSLNDR CCCCHHHHHHHHHHH	31.42	30242111
101	Sulfoxidation	TGNEKETMQSLNDRL CCCHHHHHHHHHHHH	2.39	28183972
103	Phosphorylation	NEKETMQSLNDRLAG CHHHHHHHHHHHHHH	20.51	28188228
111	Phosphorylation	LNDRLAGYLEKVRQL HHHHHHHHHHHHHHH	13.18	24719451
139	Phosphorylation	WCEQQVPYMCPDYQS HHHHHCCCCCCCHHH	16.70	22817900
144	Phosphorylation	VPYMCPDYQSYFRTI CCCCCCCHHHHHHHH	5.63	22817900
147	Phosphorylation	MCPDYQSYFRTIEEL CCCCHHHHHHHHHHH	4.99	18083107
186	Phosphorylation	ADDFRTKYETEVSLR HHHHHHHHHHHHHHH	27.72	-
289	Phosphorylation	RDAEDWLDTQSEELN CCHHHHHHHCCHHHH	38.15	17081983
302	Phosphorylation	LNQQVVSSSEQLQSC HHHHHCCCHHHHHHH	26.70	17081983
319	Phosphorylation	EIIELRRTVNALEIE HHHHHHHHHHHHHHH	16.21	20068231
332	Phosphorylation	IELQAQHSMRDALES HHHHHHHHHHHHHHH	11.93	21082442
339	Phosphorylation	SMRDALESTLAETEA HHHHHHHHHHHHHHH	29.57	-
340	Phosphorylation	MRDALESTLAETEAR HHHHHHHHHHHHHHH	22.17	-
344	Phosphorylation	LESTLAETEARYSSQ HHHHHHHHHHHHHHH	29.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KRT35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRT35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRT35_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KRT35_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.