FABPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FABPL_HUMAN
• UniProt AC: P07148
• Protein Name: Fatty acid-binding protein, liver
• Gene Name: FABP1
• Organism: Homo sapiens (Human).
• Sequence Length: 127
• Subcellular Localization: Cytoplasm.
• Protein Description: Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. [PubMed: 25732850 Binds cholesterol]
• Protein Sequence: MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MSFSGKYQ -------CCCCCCCC	9.12	3838309
11	Phosphorylation	SGKYQLQSQENFEAF CCCCCCCCHHHHHHH	48.32	20166139
31	Succinylation	LPEELIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	-
31	Succinylation	LPEELIQKGKDIKGV CCHHHHHCCCCCCCH	62.02	-
33	Acetylation	EELIQKGKDIKGVSE HHHHHCCCCCCCHHH	64.41	20167786
36	Succinylation	IQKGKDIKGVSEIVQ HHCCCCCCCHHHHHH	64.49	-
36	Succinylation	IQKGKDIKGVSEIVQ HHCCCCCCCHHHHHH	64.49	-
39	Phosphorylation	GKDIKGVSEIVQNGK CCCCCCHHHHHHCCC	30.21	-
46	Acetylation	SEIVQNGKHFKFTIT HHHHHCCCEEEEEEE	54.11	20167786
46	Succinylation	SEIVQNGKHFKFTIT HHHHHCCCEEEEEEE	54.11	-
46	Succinylation	SEIVQNGKHFKFTIT HHHHHCCCEEEEEEE	54.11	-
49	Acetylation	VQNGKHFKFTITAGS HHCCCEEEEEEECCC	41.12	27178108
51	Phosphorylation	NGKHFKFTITAGSKV CCCEEEEEEECCCEE	20.29	28857561
53	Phosphorylation	KHFKFTITAGSKVIQ CEEEEEEECCCEEEC	23.16	20166139
56	Phosphorylation	KFTITAGSKVIQNEF EEEEECCCEEECCEE	22.68	28857561
57	Succinylation	FTITAGSKVIQNEFT EEEECCCEEECCEEE	42.30	-
57	Succinylation	FTITAGSKVIQNEFT EEEECCCEEECCEEE	42.30	-
64	Phosphorylation	KVIQNEFTVGEECEL EEECCEEECCCEEEE	22.79	28857561
78	Succinylation	LETMTGEKVKTVVQL EEECCCCEEEEEEEE	50.83	-
78	Succinylation	LETMTGEKVKTVVQL EEECCCCEEEEEEEE	50.83	-
81	Phosphorylation	MTGEKVKTVVQLEGD CCCCEEEEEEEEECC	28.97	22798277
90	Succinylation	VQLEGDNKLVTTFKN EEEECCCCEEEEECC	49.42	-
90	Succinylation	VQLEGDNKLVTTFKN EEEECCCCEEEEECC	49.42	-
100	Phosphorylation	TTFKNIKSVTELNGD EEECCCCCHHEECCC	30.40	28258704
121	Succinylation	TLGDIVFKRISKRI- CHHHHHHHHHHHCC-	37.62	-
121	Acetylation	TLGDIVFKRISKRI- CHHHHHHHHHHHCC-	37.62	156649
121	Succinylation	TLGDIVFKRISKRI- CHHHHHHHHHHHCC-	37.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FABPL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FABPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FABPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNA_HUMAN	FLNA	physical	25416956
GNA1_HUMAN	GNPNAT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB02659: Cholic Acid