GPAN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPAN1_HUMAN
• UniProt AC: O95872
• Protein Name: G patch domain and ankyrin repeat-containing protein 1
• Gene Name: GPANK1
• Organism: Homo sapiens (Human).
• Sequence Length: 356
• Protein Sequence: MSRPLLITFTPATDPSDLWKDGQQQPQPEKPESTLDGAAARAFYEALIGDESSAPDSQRSQTEPARERKRKKRRIMKAPAAEAVAEGASGRHGQGRSLEAEDKMTHRILRAAQEGDLPELRRLLEPHEAGGAGGNINARDAFWWTPLMCAARAGQGAAVSYLLGRGAAWVGVCELSGRDAAQLAEEAGFPEVARMVRESHGETRSPENRSPTPSLQYCENCDTHFQDSNHRTSTAHLLSLSQGPQPPNLPLGVPISSPGFKLLLRGGWEPGMGLGPRGEGRANPIPTVLKRDQEGLGYRSAPQPRVTHFPAWDTRAVAGRERPPRVATLSWREERRREEKDRAWERDLRTYMNLEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Ubiquitination	QQQPQPEKPESTLDG CCCCCCCCCCCCHHH	61.85	-
44	Phosphorylation	GAAARAFYEALIGDE HHHHHHHHHHHHCCC	10.17	28796482
77	Sumoylation	RKKRRIMKAPAAEAV HHHHHHHHHHHHHHH	49.17	-
77	Ubiquitination	RKKRRIMKAPAAEAV HHHHHHHHHHHHHHH	49.17	-
77	Sumoylation	RKKRRIMKAPAAEAV HHHHHHHHHHHHHHH	49.17	-
103	Ubiquitination	RSLEAEDKMTHRILR CCCHHHHHHHHHHHH	36.88	-
103	Sumoylation	RSLEAEDKMTHRILR CCCHHHHHHHHHHHH	36.88	-
103	Sumoylation	RSLEAEDKMTHRILR CCCHHHHHHHHHHHH	36.88	-
210	Phosphorylation	TRSPENRSPTPSLQY CCCCCCCCCCCCCHH	44.71	24719451
212	Phosphorylation	SPENRSPTPSLQYCE CCCCCCCCCCCHHCC	27.10	28348404
214	Phosphorylation	ENRSPTPSLQYCENC CCCCCCCCCHHCCCC	30.50	28348404
256	Phosphorylation	LPLGVPISSPGFKLL CCCCCCCCCCCEEEE	25.14	18669648
257	Phosphorylation	PLGVPISSPGFKLLL CCCCCCCCCCEEEEE	29.75	28348404
261	Ubiquitination	PISSPGFKLLLRGGW CCCCCCEEEEECCCC	44.11	-
290	Ubiquitination	NPIPTVLKRDQEGLG CCCCCCCCCCCCCCC	49.98	-
290	Sumoylation	NPIPTVLKRDQEGLG CCCCCCCCCCCCCCC	49.98	28112733
330	Phosphorylation	PPRVATLSWREERRR CCCEEECCHHHHHHH	21.52	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPAN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPAN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPAN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CC85B_HUMAN	CCDC85B	physical	16189514
A4_HUMAN	APP	physical	21832049
PNMA1_HUMAN	PNMA1	physical	25416956
CC184_HUMAN	CCDC184	physical	25416956
TGM1_HUMAN	TGM1	physical	26186194
TTC19_HUMAN	TTC19	physical	26186194
LX12B_HUMAN	ALOX12B	physical	26186194
LZTS2_HUMAN	LZTS2	physical	21516116
TTC19_HUMAN	TTC19	physical	28514442
IL37_HUMAN	IL37	physical	28514442
TGM1_HUMAN	TGM1	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442
KPRP_HUMAN	KPRP	physical	28514442
HDGR3_HUMAN	HDGFRP3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.