| UniProt ID | PCDB5_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y5E4 | |
| Protein Name | Protocadherin beta-5 | |
| Gene Name | PCDHB5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 795 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. |
|
| Protein Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.. | |
| Protein Sequence | METALAKTPQKRQVMFLAILLLLWEAGSEAVRYSIPEETESGYSVANLAKDLGLGVGELATRGARMHYKGNKELLQLDIKTGNLLLYEKLDREVMCGATEPCILHFQLLLENPVQFFQTDLQLTDINDHAPEFPEKEMLLKIPESTQPGTVFPLKIAQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVVLDNNDNAPEFLQSFYEVQVPENSPLNSLVVVVSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVVDVNDNAPELTMSTLSSPTPENAPETVVAVFSVSDPDSGDNGRMICSIQNDLPFLLKPTLKNFYTLVTQRTLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCLTGDSGAGEFKFLKPIIPNLLPQGAGEEIGKTAAFRNSFGLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Methylation | -METALAKTPQKRQV -CCCCCCCCHHHHHH | 62.68 | - | |
| 43 | Phosphorylation | PEETESGYSVANLAK CCCCCCCCCHHHHHH | 14.84 | - | |
| 150 | Phosphorylation | PESTQPGTVFPLKIA CCCCCCCCEEEEEEE | 26.17 | - | |
| 169 | N-linked_Glycosylation | IGSNTVQNYTISPNS CCCCEEEEEEECCCC | 31.42 | UniProtKB CARBOHYD | |
| 182 | Phosphorylation | NSHFHVATHNRGDGR CCCEEEEECCCCCCC | 20.70 | 24719451 | |
| 191 | Phosphorylation | NRGDGRKYPELVLDK CCCCCCCCCHHHHHH | 10.69 | 19658100 | |
| 296 | Acetylation | QPFVIDEKTAEIRLK CCEEECCCCCEEEEH | 49.65 | - | |
| 400 | Phosphorylation | KPTLKNFYTLVTQRT CHHHHHHHHHHEEEC | 14.46 | 24043423 | |
| 401 | Phosphorylation | PTLKNFYTLVTQRTL HHHHHHHHHHEEECC | 15.60 | 24043423 | |
| 404 | Phosphorylation | KNFYTLVTQRTLDRE HHHHHHHEEECCCCC | 18.55 | 24043423 | |
| 407 | Phosphorylation | YTLVTQRTLDRESQA HHHHEEECCCCCCCE | 24.16 | 24043423 | |
| 412 | Phosphorylation | QRTLDRESQAEYNIT EECCCCCCCEEEEEE | 35.27 | 24043423 | |
| 416 | Phosphorylation | DRESQAEYNITITVT CCCCCEEEEEEEEEE | 18.19 | 22210691 | |
| 417 | N-linked_Glycosylation | RESQAEYNITITVTD CCCCEEEEEEEEEEC | 19.21 | UniProtKB CARBOHYD | |
| 419 | Phosphorylation | SQAEYNITITVTDMG CCEEEEEEEEEECCC | 13.63 | 22468782 | |
| 421 | Phosphorylation | AEYNITITVTDMGTP EEEEEEEEEECCCCC | 14.54 | 22210691 | |
| 423 | Phosphorylation | YNITITVTDMGTPRL EEEEEEEECCCCCCC | 16.18 | 22468782 | |
| 427 | Phosphorylation | ITVTDMGTPRLKTEH EEEECCCCCCCEEEC | 9.90 | 22468782 | |
| 435 | N-linked_Glycosylation | PRLKTEHNITVLVSD CCCEEECCEEEEEEC | 25.95 | UniProtKB CARBOHYD | |
| 566 | N-linked_Glycosylation | FVLYPLQNGSAPCTE EEEEECCCCCCCCCC | 54.81 | UniProtKB CARBOHYD | |
| 767 | Ubiquitination | AGEFKFLKPIIPNLL CCCEEECCCCCCCCC | 36.98 | - | |
| 784 | Ubiquitination | GAGEEIGKTAAFRNS CCCCCCCCCHHHHHC | 40.42 | - | |
| 791 | Phosphorylation | KTAAFRNSFGLN--- CCHHHHHCCCCC--- | 19.21 | 22199227 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PCDB5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PCDB5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PCDB5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TP4A2_HUMAN | PTP4A2 | physical | 28514442 | |
| AT2A3_HUMAN | ATP2A3 | physical | 28514442 | |
| RDH13_HUMAN | RDH13 | physical | 28514442 | |
| RL23_HUMAN | RPL23 | physical | 28514442 | |
| GAS6_HUMAN | GAS6 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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