NEUR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUR3_HUMAN
• UniProt AC: Q9UQ49
• Protein Name: Sialidase-3
• Gene Name: NEU3
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Subcellular Localization: Cell membrane ; Peripheral membrane protein .
• Protein Description: Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates..
• Protein Sequence: MEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQWGPLKPLMEATLPGHRTMNPCPVWEQKSGCVFLFFICVRGHVTERQQIVSGRNAARLCFIYSQDAGCSWSEVRDLTEEVIGSELKHWATFAVGPGHGIQLQSGRLVIPAYTYYIPSWFFCFQLPCKTRPHSLMIYSDDLGVTWHHGRLIRPMVTVECEVAEVTGRAGHPVLYCSARTPNRCRAEALSTDHGEGFQRLALSRQLCEPPHGCQGSVVSFRPLEIPHRCQDSSSKDAPTIQQSSPGSSLRLEEEAGTPSESWLLYSHPTSRKQRVDLGIYLNQTPLEAACWSRPWILHCGPCGYSDLAALEEEGLFGCLFECGTKQECEQIAFRLFTHREILSHLQGDCTSPGRNPSQFKSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	QEDDRGITYRIPALL CCCCCCCCEEECEEE	15.01	-
24	Phosphorylation	EDDRGITYRIPALLY CCCCCCCEEECEEEE	12.48	-
31	Phosphorylation	YRIPALLYIPPTHTF EEECEEEEECCCHHH	16.54	-
35	Phosphorylation	ALLYIPPTHTFLAFA EEEEECCCHHHHHHH	28.35	-
44	Ubiquitination	TFLAFAEKRSTRRDE HHHHHHHHHCCCCCH	48.49	-
74	Ubiquitination	LVQWGPLKPLMEATL EEECCCCHHHEECCC	38.96	-
77	Ubiquitination	WGPLKPLMEATLPGH CCCCHHHEECCCCCC	4.46	-
107	Ubiquitination	VFLFFICVRGHVTER EEEEEEEECCCCCCH	7.59	-
154	Ubiquitination	EVIGSELKHWATFAV HHHCHHHHCEEEEEE	32.80	-
171	Phosphorylation	GHGIQLQSGRLVIPA CCCEEECCCCEEEEC	34.18	26074081
179	Phosphorylation	GRLVIPAYTYYIPSW CCEEEECEEEEECCE	7.01	26074081
180	Phosphorylation	RLVIPAYTYYIPSWF CEEEECEEEEECCEE	16.38	26074081
181	Phosphorylation	LVIPAYTYYIPSWFF EEEECEEEEECCEEE	6.16	26074081
182	Phosphorylation	VIPAYTYYIPSWFFC EEECEEEEECCEEEE	9.88	26074081
187	Ubiquitination	TYYIPSWFFCFQLPC EEEECCEEEEEECCC	4.48	-
241	Phosphorylation	RAGHPVLYCSARTPN CCCCEEEEEECCCCC	5.65	21945579
243	Phosphorylation	GHPVLYCSARTPNRC CCEEEEEECCCCCCC	13.76	21945579
269	Phosphorylation	GFQRLALSRQLCEPP HHHHHHHHHCCCCCC	16.63	24719451
298	Phosphorylation	IPHRCQDSSSKDAPT CCCCCCCCCCCCCCC	15.61	27251275
299	Phosphorylation	PHRCQDSSSKDAPTI CCCCCCCCCCCCCCC	50.09	27251275
300	Phosphorylation	HRCQDSSSKDAPTIQ CCCCCCCCCCCCCCC	38.21	27251275
301	Ubiquitination	RCQDSSSKDAPTIQQ CCCCCCCCCCCCCCC	60.91	-
302	Phosphorylation	CQDSSSKDAPTIQQS CCCCCCCCCCCCCCC	60.78	24719451
305	Phosphorylation	SSSKDAPTIQQSSPG CCCCCCCCCCCCCCC	32.89	27732954
309	Phosphorylation	DAPTIQQSSPGSSLR CCCCCCCCCCCCCEE	23.33	30278072
310	Phosphorylation	APTIQQSSPGSSLRL CCCCCCCCCCCCEEE	29.01	30278072
313	Phosphorylation	IQQSSPGSSLRLEEE CCCCCCCCCEEEEEC	29.59	30108239
314	Phosphorylation	QQSSPGSSLRLEEEA CCCCCCCCEEEEECC	24.35	30108239
327	Phosphorylation	EAGTPSESWLLYSHP CCCCCCCEEEEEECC	27.62	30576142
331	Phosphorylation	PSESWLLYSHPTSRK CCCEEEEEECCCCCC	11.63	28796482
332	Phosphorylation	SESWLLYSHPTSRKQ CCEEEEEECCCCCCC	23.98	28796482
334	Ubiquitination	SWLLYSHPTSRKQRV EEEEEECCCCCCCCE	26.57	-
335	Phosphorylation	WLLYSHPTSRKQRVD EEEEECCCCCCCCEE	35.42	28796482
336	Phosphorylation	LLYSHPTSRKQRVDL EEEECCCCCCCCEEE	41.76	28796482
342	Phosphorylation	TSRKQRVDLGIYLNQ CCCCCCEEEEEECCC	41.17	18691976
343	Phosphorylation	SRKQRVDLGIYLNQT CCCCCEEEEEECCCC	4.04	27251275
346	Phosphorylation	QRVDLGIYLNQTPLE CCEEEEEECCCCCCH	9.59	22817900
347	Phosphorylation	RVDLGIYLNQTPLEA CEEEEEECCCCCCHH	3.46	27251275
409	Phosphorylation	FTHREILSHLQGDCT HHHHHHHHHCCCCCC	28.01	29978859
416	Phosphorylation	SHLQGDCTSPGRNPS HHCCCCCCCCCCCHH	42.57	23401153
417	Phosphorylation	HLQGDCTSPGRNPSQ HCCCCCCCCCCCHHH	31.52	25159151
423	Phosphorylation	TSPGRNPSQFKSN-- CCCCCCHHHHCCC--	52.37	29978859
426	Methylation	GRNPSQFKSN----- CCCHHHHCCC-----	41.26	82982557
426	Ubiquitination	GRNPSQFKSN----- CCCHHHHCCC-----	41.26	-
450	Phosphorylation	----------------------------- -----------------------------		24719451
459	Ubiquitination	-------------------------------------- --------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_HUMAN	GRB2	physical	12730204

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-417, AND MASSSPECTROMETRY.
PubMed: 18691976