M4K3_HUMAN - dbPTM
M4K3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID M4K3_HUMAN
UniProt AC Q8IVH8
Protein Name Mitogen-activated protein kinase kinase kinase kinase 3
Gene Name MAP4K3
Organism Homo sapiens (Human).
Sequence Length 894
Subcellular Localization
Protein Description May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway..
Protein Sequence MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNPGFDLS
-------CCCCCCCC		14.2422223895
8PhosphorylationMNPGFDLSRRNPQED
CCCCCCCCCCCHHHH		30.9128857561
24PhosphorylationELIQRIGSGTYGDVY
HHHHHHCCCCCCCEE		26.1221406692
26PhosphorylationIQRIGSGTYGDVYKA
HHHHCCCCCCCEEEE		26.4821406692
27PhosphorylationQRIGSGTYGDVYKAR
HHHCCCCCCCEEEEE		18.1721406692
31PhosphorylationSGTYGDVYKARNVNT
CCCCCCEEEEECCCC		12.0421406692
32UbiquitinationGTYGDVYKARNVNTG
CCCCCEEEEECCCCC		40.49-
145PhosphorylationKGANILLTDNGHVKL
CCCCEEEECCCCEEE		24.7927251275
158PhosphorylationKLADFGVSAQITATI
EECHHCCEEEEEEEH		18.1626074081
162PhosphorylationFGVSAQITATIAKRK
HCCEEEEEEEHHHCC		12.9826074081
164PhosphorylationVSAQITATIAKRKSF
CEEEEEEEHHHCCCC		16.9026074081
167UbiquitinationQITATIAKRKSFIGT
EEEEEHHHCCCCCCC		57.41-
170PhosphorylationATIAKRKSFIGTPYW
EEHHHCCCCCCCCCC		26.5730108239
174PhosphorylationKRKSFIGTPYWMAPE
HCCCCCCCCCCCCHH		14.3730108239
176PhosphorylationKSFIGTPYWMAPEVA
CCCCCCCCCCCHHHH		13.9826074081
227PhosphorylationMRALFLMTKSNFQPP
HHHHHHHCCCCCCCC		33.2127174698
229PhosphorylationALFLMTKSNFQPPKL
HHHHHCCCCCCCCCH		33.4427174698
280PhosphorylationVTQHLTRSLAIELLD
HHHHHHHHHHHHHHH		19.5422617229
295PhosphorylationKVNNPDHSTYHDFDD
HCCCCCCCCCCCCCC		37.7329978859
296PhosphorylationVNNPDHSTYHDFDDD
CCCCCCCCCCCCCCC		22.8129978859
297PhosphorylationNNPDHSTYHDFDDDD
CCCCCCCCCCCCCCC		11.4729978859
327PhosphorylationRNVREEKTRSEITFG
CCCCCHHHHCCEEEE		42.5828176443
329PhosphorylationVREEKTRSEITFGQV
CCCHHHHCCEEEEEC		38.2828176443
332PhosphorylationEKTRSEITFGQVKFD
HHHHCCEEEEECCCC		20.0523403867
346 (in isoform 3)Phosphorylation-58.8320049867
355PhosphorylationPHHELPDSDGFLDSS
CCCCCCCCCCCCCCC		37.3827642862
358 (in isoform 3)Phosphorylation-9.1027642862
361PhosphorylationDSDGFLDSSEEIYYT
CCCCCCCCCCHHEEH		41.6229978859
362PhosphorylationSDGFLDSSEEIYYTA
CCCCCCCCCHHEEHH		38.6327642862
366 (in isoform 3)Phosphorylation-9.6927642862
366PhosphorylationLDSSEEIYYTARSNL
CCCCCHHEEHHHHCC		9.6929978859
367PhosphorylationDSSEEIYYTARSNLD
CCCCHHEEHHHHCCE		10.2829978859
368PhosphorylationSSEEIYYTARSNLDL
CCCHHEEHHHHCCEE		9.9127642862
371PhosphorylationEIYYTARSNLDLQLE
HHEEHHHHCCEEEEE		39.0028348404
379PhosphorylationNLDLQLEYGQGHQGG
CCEEEEECCCCCCCC		24.2822817900
387PhosphorylationGQGHQGGYFLGANKS
CCCCCCCEEECCCHH		11.4922817900
394PhosphorylationYFLGANKSLLKSVEE
EEECCCHHHHHHHHH		38.4524719451
397UbiquitinationGANKSLLKSVEEELH
CCCHHHHHHHHHHHH		58.72-
398PhosphorylationANKSLLKSVEEELHQ
CCHHHHHHHHHHHHH		34.4320227368
422PhosphorylationDEGDDDESKHSTLKA
CCCCCCCHHCCCHHC		42.5424275569
426PhosphorylationDDESKHSTLKAKIPP
CCCHHCCCHHCCCCC		31.8124275569
450PhosphorylationFIPQEMHSTEDENQG
ECCCCCCCCCCCCCC		31.9828555341
451PhosphorylationIPQEMHSTEDENQGT
CCCCCCCCCCCCCCC		32.5528857561
458PhosphorylationTEDENQGTIKRCPMS
CCCCCCCCEEECCCC		17.3528857561
465PhosphorylationTIKRCPMSGSPAKPS
CEEECCCCCCCCCCC		22.6628102081
467PhosphorylationKRCPMSGSPAKPSQV
EECCCCCCCCCCCCC		17.8725159151
472PhosphorylationSGSPAKPSQVPPRPP
CCCCCCCCCCCCCCC		43.0028122231
507PhosphorylationLNGERDGSLCQQQNE
CCCCCCCCHHHHHHC		30.2025849741
530AcetylationKEKKDVPKPISNGLP
HHCCCCCCCCCCCCC		55.637825305
533PhosphorylationKDVPKPISNGLPPTP
CCCCCCCCCCCCCCC		33.11-
539PhosphorylationISNGLPPTPKVHMGA
CCCCCCCCCCCCHHH		33.53-
541AcetylationNGLPPTPKVHMGACF
CCCCCCCCCCHHHHH		47.457825317
604S-palmitoylationEQLFPRRCTWLYVMN
HHHHCCCCHHHHHHC		3.1929575903
613S-palmitoylationWLYVMNNCLLSISGK
HHHHHCCEEEEECCC		3.2529575903
616PhosphorylationVMNNCLLSISGKASQ
HHCCEEEEECCCHHH		11.1923401153
618PhosphorylationNNCLLSISGKASQLY
CCEEEEECCCHHHHH		30.7521082442
625PhosphorylationSGKASQLYSHNLPGL
CCCHHHHHHCCCCCH		10.5527067055
626PhosphorylationGKASQLYSHNLPGLF
CCHHHHHHCCCCCHH		17.9427067055
661PhosphorylationRILPRKFSVSAKIPE
CCCCCCCEECEECCC		20.4218691976
663PhosphorylationLPRKFSVSAKIPETK
CCCCCEECEECCCCC		23.7328102081
735PhosphorylationLVVPEQEYPLVCVGV
EECCCCCCCEEEEEE		11.10-
743PhosphorylationPLVCVGVSRGRDFNQ
CEEEEEECCCCCCCC		24.08-
893PhosphorylationILAGHENSY------
EEECCCCCC------		29.2727251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
170SPhosphorylationKinaseMAP4K3Q8IVH8
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of M4K3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of M4K3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRBS1_HUMANSORBS1physical
20936779
CSN5_HUMANCOPS5physical
20936779
ITSN2_HUMANITSN2physical
20936779
SH3R1_HUMANSH3RF1physical
20936779
PCBP1_HUMANPCBP1physical
25852190
M4K5_HUMANMAP4K5physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of M4K3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-327; SER-398 ANDSER-893, AND MASS SPECTROMETRY.

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