STA10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STA10_HUMAN
• UniProt AC: Q9Y365
• Protein Name: START domain-containing protein 10
• Gene Name: STARD10
• Organism: Homo sapiens (Human).
• Sequence Length: 291
• Subcellular Localization: Cell projection, cilium, flagellum. Cytoplasm . Membrane . In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic..
• Protein Description: May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes..
• Protein Sequence: MEKLAASTEPQGPRPVLGRESVQVPDDQDFRSFRSECEAEVGWNLTYSRAGVSVWVQAVEMDRTLHKIKCRMECCDVPAETLYDVLHDIEYRKKWDSNVIETFDIARLTVNADVGYYSWRCPKPLKNRDVITLRSWLPMGADYIIMNYSVKHPKYPPRKDLVRAVSIQTGYLIQSTGPKSCVITYLAQVDPKGSLPKWVVNKSSQFLAPKAMKKMYKACLKYPEWKQKHLPHFKPWLHPEQSPLPSLALSELSVQHADSLENIDESAVAESREERMGGAGGEGSDDDTSLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKLAAST -------CCCHHCCC		22814378
7	Phosphorylation	-MEKLAASTEPQGPR -CCCHHCCCCCCCCC		25849741
8	Phosphorylation	MEKLAASTEPQGPRP CCCHHCCCCCCCCCC		26270265
21	Phosphorylation	RPVLGRESVQVPDDQ CCCCCCCCCCCCCCC		24719451
94	Succinylation	HDIEYRKKWDSNVIE HHHHHHHCCCCCCEE		-
94	Succinylation	HDIEYRKKWDSNVIE HHHHHHHCCCCCCEE		-
97	Phosphorylation	EYRKKWDSNVIETFD HHHHCCCCCCEEEEE		27174698
102	Phosphorylation	WDSNVIETFDIARLT CCCCCEEEEEEEEEE		27174698
109	Phosphorylation	TFDIARLTVNADVGY EEEEEEEEECCCCEE		27174698
143	Phosphorylation	WLPMGADYIIMNYSV CCCCCCCEEEEECCC		-
148	Phosphorylation	ADYIIMNYSVKHPKY CCEEEEECCCCCCCC		-
155	Phosphorylation	YSVKHPKYPPRKDLV CCCCCCCCCCHHHHH		-
166	Phosphorylation	KDLVRAVSIQTGYLI HHHHEEEEHHHCEEE		24719451
194	Phosphorylation	AQVDPKGSLPKWVVN EECCCCCCCCHHHCC		28348404
197	Succinylation	DPKGSLPKWVVNKSS CCCCCCCHHHCCCCC		-
197	Succinylation	DPKGSLPKWVVNKSS CCCCCCCHHHCCCCC		-
202	Succinylation	LPKWVVNKSSQFLAP CCHHHCCCCCCCCCH		-
202	Succinylation	LPKWVVNKSSQFLAP CCHHHCCCCCCCCCH		-
203	Phosphorylation	PKWVVNKSSQFLAPK CHHHCCCCCCCCCHH		30622161
204	Phosphorylation	KWVVNKSSQFLAPKA HHHCCCCCCCCCHHH		30622161
242	Phosphorylation	PWLHPEQSPLPSLAL CCCCCCCCCCCHHHH		26330541
246	Phosphorylation	PEQSPLPSLALSELS CCCCCCCHHHHHHHH		26330541
250	Phosphorylation	PLPSLALSELSVQHA CCCHHHHHHHHHHCH		26657352
253	Phosphorylation	SLALSELSVQHADSL HHHHHHHHHHCHHHH		29759185
259	Phosphorylation	LSVQHADSLENIDES HHHHCHHHHCCCCHH		15704244
266	Phosphorylation	SLENIDESAVAESRE HHCCCCHHHHHHHHH		28102081
284	Phosphorylation	GGAGGEGSDDDTSLT CCCCCCCCCCCCCCC		25159151
288	Phosphorylation	GEGSDDDTSLT---- CCCCCCCCCCC----		30278072
289	Phosphorylation	EGSDDDTSLT----- CCCCCCCCCC-----		30278072
291	Phosphorylation	SDDDTSLT------- CCCCCCCC-------		28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
284	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
284	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
284	S	Phosphorylation	Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.	17561512

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STA10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ANM6_HUMAN	PRMT6	physical	23455924

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.