ASAP2_HUMAN - dbPTM
ASAP2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ASAP2_HUMAN
UniProt AC O43150
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Gene Name ASAP2
Organism Homo sapiens (Human).
Sequence Length 1006
Subcellular Localization Cytoplasm. Golgi apparatus, Golgi stack membrane
Peripheral membrane protein. Cell membrane
Peripheral membrane protein. Colocalizes with F-actin and ARF6 in phagocytic cups.
Protein Description Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration..
Protein Sequence MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59MalonylationYKMKKSVKAINSSGL
HHHHHHHHHHHCCCC		51.1126320211
75PhosphorylationHVENEEQYTQALEKF
CCCCHHHHHHHHHHH		12.2327642862
75 (in isoform 2)Nitration-12.23-
81UbiquitinationQYTQALEKFGGNCVC
HHHHHHHHHCCCEEE		50.5929967540
129PhosphorylationIISFPLDSLLKGDLK
HHHCCHHHHCCCCCC		43.1924719451
201PhosphorylationFQLQMCEYLLKVNEI
HHHHHHHHHHHHCCC		16.65-
212UbiquitinationVNEIKIKKGVDLLQN
HCCCCHHHHHHHHHH		68.58-
242UbiquitinationLKAVESLKPSIETLS
HHHHHHHCCHHHHHC		46.1029967540
242AcetylationLKAVESLKPSIETLS
HHHHHHHCCHHHHHC		46.1023954790
244PhosphorylationAVESLKPSIETLSTD
HHHHHCCHHHHHCCC		31.3121406692
247PhosphorylationSLKPSIETLSTDLHT
HHCCHHHHHCCCHHH		25.0821406692
249PhosphorylationKPSIETLSTDLHTIK
CCHHHHHCCCHHHHH		27.5621406692
250PhosphorylationPSIETLSTDLHTIKQ
CHHHHHCCCHHHHHH		45.7721406692
254PhosphorylationTLSTDLHTIKQAQDE
HHCCCHHHHHHCCHH		36.8521406692
274UbiquitinationIQLRDILKSALQVEQ
HHHHHHHHHHHCHHH		33.7329967540
282UbiquitinationSALQVEQKEDSQIRQ
HHHCHHHHHCHHHHH		50.4029967540
285PhosphorylationQVEQKEDSQIRQSTA
CHHHHHCHHHHHHHC		28.7128857561
290PhosphorylationEDSQIRQSTAYSLHQ
HCHHHHHHHCHHCCC		12.7328555341
293PhosphorylationQIRQSTAYSLHQPQG
HHHHHHCHHCCCCCC		16.3225159151
294PhosphorylationIRQSTAYSLHQPQGN
HHHHHCHHCCCCCCC		19.5325394399
311PhosphorylationHGTERNGSLYKKSDG
CCCCCCCCEEECCCC		31.8824719451
313PhosphorylationTERNGSLYKKSDGIR
CCCCCCEEECCCCHH		20.3329978859
321AcetylationKKSDGIRKVWQKRKC
ECCCCHHHHHHHCCC		46.006570287
325AcetylationGIRKVWQKRKCSVKN
CHHHHHHHCCCEEEC		37.816570225
329PhosphorylationVWQKRKCSVKNGFLT
HHHHCCCEEECCEEE		38.8822817900
336PhosphorylationSVKNGFLTISHGTAN
EEECCEEEEECCCCC		20.4122817900
338PhosphorylationKNGFLTISHGTANRP
ECCEEEEECCCCCCC		15.6122817900
405UbiquitinationEALNNAFKGDDNTGE
HHHHHHCCCCCCCCC		60.0529967540
546UbiquitinationKHADNAAKLHSLCEA
HHHCHHHHHHHHHHH		44.3029967540
549PhosphorylationDNAAKLHSLCEAVKT
CHHHHHHHHHHHHHH		45.1928857561
555UbiquitinationHSLCEAVKTRDIFGL
HHHHHHHHHHHHHHH		44.9129967540
556PhosphorylationSLCEAVKTRDIFGLL
HHHHHHHHHHHHHHH		27.29-
662UbiquitinationETPLDIAKRLKHEHC
CCHHHHHHHHCHHHH		59.6129967540
689PhosphorylationNSHVHVEYEWRLLHE
CCCCEEEEEEEHHHC		21.5027642862
701PhosphorylationLHEDLDESDDDMDEK
HHCCCCCCCCCHHHH		46.1129255136
712PhosphorylationMDEKLQPSPNRREDR
HHHHCCCCCCCCCCC		23.1123403867
722PhosphorylationRREDRPISFYQLGSN
CCCCCCCCEEECCCC		22.1526657352
724PhosphorylationEDRPISFYQLGSNQL
CCCCCCEEECCCCHH		8.9525106551
728PhosphorylationISFYQLGSNQLQSNA
CCEEECCCCHHHHHH		29.9629978859
737PhosphorylationQLQSNAVSLARDAAN
HHHHHHHHHHHHHHH		17.5624719451
756PhosphorylationKQRAFMPSILQNETY
HHHHHCCHHHCCCCH		24.9226356563
762PhosphorylationPSILQNETYGALLSG
CHHHCCCCHHHHHCC		34.5026356563
763PhosphorylationSILQNETYGALLSGS
HHHCCCCHHHHHCCC		8.3327259358
768PhosphorylationETYGALLSGSPPPAQ
CCHHHHHCCCCCCCC		37.7726356563
770PhosphorylationYGALLSGSPPPAQPA
HHHHHCCCCCCCCCC		30.7526356563
780PhosphorylationPAQPAAPSTTSAPPL
CCCCCCCCCCCCCCC		39.3226356563
781PhosphorylationAQPAAPSTTSAPPLP
CCCCCCCCCCCCCCC		24.5826356563
782PhosphorylationQPAAPSTTSAPPLPP
CCCCCCCCCCCCCCC		27.5126356563
783PhosphorylationPAAPSTTSAPPLPPR
CCCCCCCCCCCCCCC		38.5826356563
797PhosphorylationRNVGKVQTASSANTL
CCCCCEEECCCCCCE		31.3423312004
798 (in isoform 2)Phosphorylation-5.6126657352
799PhosphorylationVGKVQTASSANTLWK
CCCEEECCCCCCEEE		33.1128857561
800 (in isoform 2)Phosphorylation-24.0722199227
800PhosphorylationGKVQTASSANTLWKT
CCEEECCCCCCEEEC		24.0728857561
803PhosphorylationQTASSANTLWKTNSV
EECCCCCCEEECCEE		33.4428857561
807PhosphorylationSANTLWKTNSVSVDG
CCCCEEECCEEECCC		22.5728102081
809PhosphorylationNTLWKTNSVSVDGGS
CCEEECCEEECCCCC		22.4728857561
811PhosphorylationLWKTNSVSVDGGSRQ
EEECCEEECCCCCCC		17.8227535140
816PhosphorylationSVSVDGGSRQRSSSD
EEECCCCCCCCCCCC		30.6728102081
820PhosphorylationDGGSRQRSSSDPPAV
CCCCCCCCCCCCCCC		26.3430278072
821PhosphorylationGGSRQRSSSDPPAVH
CCCCCCCCCCCCCCC		40.7330278072
822PhosphorylationGSRQRSSSDPPAVHP
CCCCCCCCCCCCCCC		56.2230278072
837PhosphorylationPLPPLRVTSTNPLTP
CCCCCCEEECCCCCC		24.3328060719
838PhosphorylationLPPLRVTSTNPLTPT
CCCCCEEECCCCCCC		24.2728060719
839PhosphorylationPPLRVTSTNPLTPTP
CCCCEEECCCCCCCC		31.3324719451
843PhosphorylationVTSTNPLTPTPPPPV
EEECCCCCCCCCCCC		26.7728060719
845PhosphorylationSTNPLTPTPPPPVAK
ECCCCCCCCCCCCCC		43.1028985074
899PhosphorylationPAPGADKSTPLTNKG
CCCCCCCCCCCCCCC		35.4921406692
900PhosphorylationAPGADKSTPLTNKGQ
CCCCCCCCCCCCCCC		28.2321406692
903PhosphorylationADKSTPLTNKGQPRG
CCCCCCCCCCCCCCC		35.7721406692
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ASAP2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ASAP2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ASAP2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PAXI_HUMANPXNphysical
10749932
FAK2_HUMANPTK2Bphysical
10022920
SRC_HUMANSRCphysical
10022920
SH3K1_HUMANSH3KBP1physical
25416956
RFIP3_HUMANRAB11FIP3physical
18685082
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ASAP2_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701 AND SER-822, ANDMASS SPECTROMETRY.
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory