CSF3R_HUMAN - dbPTM
CSF3R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CSF3R_HUMAN
UniProt AC Q99062
Protein Name Granulocyte colony-stimulating factor receptor
Gene Name CSF3R
Organism Homo sapiens (Human).
Sequence Length 836
Subcellular Localization Isoform 2: Secreted .
Cell membrane
Single-pass type I membrane protein .
Protein Description Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface..
Protein Sequence MARLGNCSLTWAALIILLLPGSLEECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSELHIILGLFGLLLLLTCLCGTAWLCCSPNRKNPLWPSVPDPAHSSLGSWVPTIMEEDAFQLPGLGTPPITKLTVLEEDEKKPVPWESHNSSETCGLPTLVQTYVLQGDPRAVSTQPQSQSGTSDQVLYGQLLGSPTSPGPGHYLRCDSTQPLLAGLTPSPKSYENLWFQASPLGTLVTPAPSQEDDCVFGPLLNFPLLQGIRVHGMEALGSF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51N-linked_GlycosylationASCIIKQNCSHLDPE
HHHEEECCCCCCCCC		25.028855939
51N-linked_GlycosylationASCIIKQNCSHLDPE
HHHEEECCCCCCCCC		25.028855939
93N-linked_GlycosylationIITLPHLNHTQAFLS
EEECCCCCHHHHHHH		32.888855939
93N-linked_GlycosylationIITLPHLNHTQAFLS
EEECCCCCHHHHHHH		32.888855939
128N-linked_GlycosylationYPPAIPHNLSCLMNL
CCCCCCCCHHHHHHC		28.448855939
128N-linked_GlycosylationYPPAIPHNLSCLMNL
CCCCCCCCHHHHHHC		28.448855939
134N-linked_GlycosylationHNLSCLMNLTTSSLI
CCHHHHHHCCCCCCE		22.6816492764
134N-linked_GlycosylationHNLSCLMNLTTSSLI
CCHHHHHHCCCCCCE		22.6816492764
160PhosphorylationPTSFTLKSFKSRGNC
CCEEEEEEHHHCCCC		40.8124719451
196PhosphorylationPRKHLLLYQNMGIWV
ECCEEEEEECCEEEE		9.60-
324PhosphorylationHWSDWSPSLELRTTE
CHHHCCCCEEEEECC		29.0324719451
351PhosphorylationQRQLDPRTVQLFWKP
HCCCCCCEEEEEEEE		20.28-
365PhosphorylationPVPLEEDSGRIQGYV
EEECCCCCCCEEEEE		33.0027732954
389N-linked_GlycosylationGAILPLCNTTELSCT
CCEEECCCCCEEEEE		58.698855939
389N-linked_GlycosylationGAILPLCNTTELSCT
CCEEECCCCCEEEEE		58.698855939
401PhosphorylationSCTFHLPSEAQEVAL
EEEEECCCCCCEEEE		52.5024275569
413PhosphorylationVALVAYNSAGTSRPT
EEEEEECCCCCCCCC		18.5224275569
416PhosphorylationVAYNSAGTSRPTPVV
EEECCCCCCCCCCEE		22.6824275569
420PhosphorylationSAGTSRPTPVVFSES
CCCCCCCCCEEEECC		27.8324275569
425PhosphorylationRPTPVVFSESRGPAL
CCCCEEEECCCCCHH		24.0524275569
427PhosphorylationTPVVFSESRGPALTR
CCEEEECCCCCHHHH		41.1424275569
474N-linked_GlycosylationPPSASNSNKTWRMEQ
CCCCCCCCCCEEEEE		50.458855939
474N-linked_GlycosylationPPSASNSNKTWRMEQ
CCCCCCCCCCEEEEE		50.458855939
571N-linked_GlycosylationIFWTNAQNQSFSAIL
EEEECCCCCCHHHHH		36.738855939
571N-linked_GlycosylationIFWTNAQNQSFSAIL
EEEECCCCCCHHHHH		36.738855939
579N-linked_GlycosylationQSFSAILNASSRGFV
CCHHHHHCCCCCCEE		31.508855939
579N-linked_GlycosylationQSFSAILNASSRGFV
CCHHHHHCCCCCCEE		31.508855939
610N-linked_GlycosylationASQAGATNSTVLTLM
HHHCCCCCCEEEEEE		34.848855939
610N-linked_GlycosylationASQAGATNSTVLTLM
HHHCCCCCCEEEEEE		34.848855939
655UbiquitinationLCCSPNRKNPLWPSV
HHCCCCCCCCCCCCC		70.3419453968
681 (in isoform 2)Phosphorylation-39.1022210691
684 (in isoform 2)Phosphorylation-48.7622210691
695UbiquitinationLGTPPITKLTVLEED
CCCCCCCEEEEEECC		42.7719453968
704UbiquitinationTVLEEDEKKPVPWES
EEEECCCCCCCCCCC		74.7719453968
705UbiquitinationVLEEDEKKPVPWESH
EEECCCCCCCCCCCC		49.561945396
727PhosphorylationLPTLVQTYVLQGDPR
CCCEEEEEEECCCCC		5.1012133942
752PhosphorylationGTSDQVLYGQLLGSP
CCCCCEEEEEHHCCC		12.1712133942
767PhosphorylationTSPGPGHYLRCDSTQ
CCCCCCCEEECCCCC		11.1916493051
772PhosphorylationGHYLRCDSTQPLLAG
CCEEECCCCCCEECC		32.3528509920
773PhosphorylationHYLRCDSTQPLLAGL
CEEECCCCCCEECCC		22.4328509920
781PhosphorylationQPLLAGLTPSPKSYE
CCEECCCCCCCCCHH		22.3228509920
783PhosphorylationLLAGLTPSPKSYENL
EECCCCCCCCCHHCC		39.4628509920
787PhosphorylationLTPSPKSYENLWFQA
CCCCCCCHHCCEEEE		18.248547634
835PhosphorylationHGMEALGSF------
CCHHHCCCC------		28.7428450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseFBXW7Q969H0
PMID:24658274
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CSF3R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CSF3R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JAK1_HUMANJAK1physical
7512720
LYN_HUMANLYNphysical
8197119
KSYK_HUMANSYKphysical
8197119
FZR1_HUMANFZR1physical
17001306
WSB1_HUMANWSB1physical
17001306
WSB2_HUMANWSB2physical
17001306
SHC1_HUMANSHC1physical
17001306
GRB2_HUMANGRB2physical
17001306
CISH_HUMANCISHphysical
15470047
FBXW7_HUMANFBXW7physical
23820376
GSK3B_HUMANGSK3Bphysical
23820376
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
162830Hereditary neutrophilia (NEUTROPHILIA)
Kegg Drug
D03235 Filgrastim (genetical recombination) (JP16); Filgrastim (USAN/INN); Filgrastim (genetical recombinat
D03245 Nartograstim (genetical recombination) (JP16); Nartograstim (INN)
D03247 Lenograstim (genetical recombination) (JP16); Lenograstim (USAN/INN); Neutrogin (TN)
D04695 Leridistim (USAN/INN)
D05036 Milodistim (USAN/INN); Pixykine (TN)
D05389 Pegnartograstim (USAN/INN)
D06889 Pegfilgrastim (genetical recombination) (JAN); Pegfilgrastim (INN); Neulasta (TN)
D10242 Lipegfilgrastim (USAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CSF3R_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex.";
Tamada T., Honjo E., Maeda Y., Okamoto T., Ishibashi M., Tokunaga M.,Kuroki R.;
Proc. Natl. Acad. Sci. U.S.A. 103:3135-3140(2006).
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-333 IN COMPLEX WITH CSF3,GLYCOSYLATION AT ASN-134, DISULFIDE BONDS, AND SUBUNIT.

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