WSB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WSB1_HUMAN
• UniProt AC: Q9Y6I7
• Protein Name: WD repeat and SOCS box-containing protein 1
• Gene Name: WSB1
• Organism: Homo sapiens (Human).
• Sequence Length: 421
• Protein Description: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation..
• Protein Sequence: MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASFPPRVNE -----CCCCCCCCCH	36.67	24719451
3 (in isoform 2)	Phosphorylation	-	36.67	24719451
11	Ubiquitination	FPPRVNEKEIVRLRT CCCCCCHHHEEEEEE	47.76	-
31	Ubiquitination	APAAPFDKKCGRENW CCCCCCCCCCCCCCE	50.79	21890473
31 (in isoform 1)	Ubiquitination	-	50.79	21890473
31	Ubiquitination	APAAPFDKKCGRENW CCCCCCCCCCCCCCE	50.79	21890473
31 (in isoform 3)	Ubiquitination	-	50.79	-
32	Ubiquitination	PAAPFDKKCGRENWT CCCCCCCCCCCCCEE	43.71	-
59	Ubiquitination	SQGHRTVKLVPWSQC ECCCCEEEEEEHHHH	43.06	-
62 (in isoform 2)	Ubiquitination	-	35.12	21890473
91	Phosphorylation	LRLPRQNSDGGQKNK EECCCCCCCCCCCCC	29.33	26074081
131	Ubiquitination	SRCVNIEWHRFRFGQ HCCEEEEEEEEECCC	5.55	21906983
187 (in isoform 2)	Ubiquitination	-	3.40	21890473
201	Ubiquitination	TLRVWDLKDDGNMMK EEEEEEECCCCCCEE	51.83	-
208	Ubiquitination	KDDGNMMKVLRGHQN CCCCCCEEEEECCCC	27.61	21890473
208 (in isoform 1)	Ubiquitination	-	27.61	21890473
208	Ubiquitination	KDDGNMMKVLRGHQN CCCCCCEEEEECCCC	27.61	21890473
316	Phosphorylation	ANDRWVRSVSFSHDG CCCCEEEEEEECCCC	16.70	27251275
318	Phosphorylation	DRWVRSVSFSHDGLH CCEEEEEEECCCCEE	23.44	27251275
320	Phosphorylation	WVRSVSFSHDGLHVA EEEEEEECCCCEEEE	17.11	27251275
328	Phosphorylation	HDGLHVASLADDKMV CCCEEEEECCCCCEE	24.01	21815630
333	Ubiquitination	VASLADDKMVRFWRI EEECCCCCEEEEEEE	39.58	2190698
333 (in isoform 1)	Ubiquitination	-	39.58	21890473
394	Phosphorylation	LQHLCRMSIRRVMPT HHHHHHHHHCCCCCC	8.13	22210691
411	Phosphorylation	VQELPIPSKLLEFLS HHCCCCCHHHHHHHH	36.33	24719451
412	Ubiquitination	QELPIPSKLLEFLSY HCCCCCHHHHHHHHC	52.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WSB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WSB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WSB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IOD2_HUMAN	DIO2	physical	15965468
HIPK2_HUMAN	HIPK2	physical	18093972
CUL5_HUMAN	CUL5	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
UB2D3_HUMAN	UBE2D3	physical	18093972
GDIR2_HUMAN	ARHGDIB	physical	26424695
LRRK2_HUMAN	LRRK2	physical	27273569
UB2D2_HUMAN	UBE2D2	physical	27273569

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.