IOD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IOD2_HUMAN
• UniProt AC: Q92813
• Protein Name: Type II iodothyronine deiodinase
• Gene Name: DIO2
• Organism: Homo sapiens (Human).
• Sequence Length: 273
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development..
• Protein Sequence: MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGEWRRMLTSEGLRCVWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGGDNSGNGTQEKIAEGATCHLLDFASPERPLVVNFGSATUPPFTSQLPAFRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSSLSFEVKKHQNQEDRCAAAQQLLERFSLPPQCRVVADRMDNNANIAYGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNFSKRUKKTRLAG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Ubiquitination	EGLRCVWKSFLLDAY HHHHHHHHHHHHHHH	15.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	WSB1	Q9Y6I7	PMID:15965468
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF6	O60337	PMID:19651899

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IOD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IOD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP33_HUMAN	USP33	physical	12865408
IOD2_HUMAN	DIO2	physical	17452445
UB2G1_HUMAN	UBE2G1	physical	17452445
WSB1_HUMAN	WSB1	physical	17452445
UBP33_HUMAN	USP33	physical	17452445
ELOB_HUMAN	TCEB2	physical	15965468
CUL5_HUMAN	CUL5	physical	15965468
ELOC_HUMAN	TCEB1	physical	15965468
RBX1_HUMAN	RBX1	physical	15965468
WSB1_HUMAN	WSB1	physical	15965468
UB2J1_HUMAN	UBE2J1	physical	12933904
UB2G1_HUMAN	UBE2G1	physical	12933904
TERA_HUMAN	VCP	physical	24196352
UBP33_HUMAN	USP33	physical	24196352
PSMD4_HUMAN	PSMD4	physical	24196352
MARH6_HUMAN	MARCH6	physical	25074266
WSB1_HUMAN	WSB1	physical	25074266

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.