WSB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WSB2_HUMAN
• UniProt AC: Q9NYS7
• Protein Name: WD repeat and SOCS box-containing protein 2
• Gene Name: WSB2
• Organism: Homo sapiens (Human).
• Sequence Length: 404
• Protein Description: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
• Protein Sequence: MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Ubiquitination	IPKGFEAKSRSSKNE CCCCCCCCCCCCCCC	38.92	27667366
86	Ubiquitination	GRGSPKEKTLDCGQI CCCCCCCCEECCCCE	61.59	27667366
160	Phosphorylation	QDVVRDLSFTPSGSL CCCEEECEECCCCCE	31.22	25278378
162	Phosphorylation	VVRDLSFTPSGSLIL CEEECEECCCCCEEE	17.11	25278378
164	Phosphorylation	RDLSFTPSGSLILVS EECEECCCCCEEEEE	37.65	25278378
166	Phosphorylation	LSFTPSGSLILVSAS CEECCCCCEEEEEEC	19.30	25278378
294	Phosphorylation	DDSDVHISSLRSVCF CCCCCCHHHHHHEEE	14.40	24719451
295	Phosphorylation	DSDVHISSLRSVCFS CCCCCHHHHHHEEEC	27.48	25954137
367	Phosphorylation	WTAPRVLSSLKHLCR ECHHHHHHHHHHHHH	30.66	24719451
379	Phosphorylation	LCRKALRSFLTTYQV HHHHHHHHHHHHHHH	26.00	23532336
384	Phosphorylation	LRSFLTTYQVLALPI HHHHHHHHHHHHCCC	7.44	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WSB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WSB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WSB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IL21R_HUMAN	IL21R	physical	20059963
SNIP1_HUMAN	SNIP1	physical	28514442
CLASR_HUMAN	CLASRP	physical	28514442
ACINU_HUMAN	ACIN1	physical	28514442
CCDC9_HUMAN	CCDC9	physical	28514442
CUL5_HUMAN	CUL5	physical	28514442
ZC3HE_HUMAN	ZC3H14	physical	28514442
ARI2_HUMAN	ARIH2	physical	28514442
NCBP3_HUMAN	C17orf85	physical	28514442
UBB_HUMAN	UBB	physical	28514442
PININ_HUMAN	PNN	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
RNPS1_HUMAN	RNPS1	physical	28514442
NKTR_HUMAN	NKTR	physical	28514442
AMRA1_HUMAN	AMBRA1	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
DDA1_HUMAN	DDA1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.