MLXPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MLXPL_HUMAN
• UniProt AC: Q9NP71
• Protein Name: Carbohydrate-responsive element-binding protein
• Gene Name: MLXIPL
• Organism: Homo sapiens (Human).
• Sequence Length: 852
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity)..
• Protein Sequence: MAGALAGLAAGLQVPRVAPSPDSDSDTDSEDPSLRRSAGGLLRSQVIHSGHFMVSSPHSDSLPRRRDQEGSVGPSDFGPRSIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVKRRKSPVCGFVTPLQGPEADAHRKPEAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKPSREDDLLAPKQAEGRWPPPEQWCKQLFSSVVPVLLGDPEEEPGGRQLLDLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFFTNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCPGPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTALLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLPLGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGSNNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPGPATLAPSRPLLVPKAERLSPPAPSGSERRLSGDLSSMPGPGTLSVRVSPPQPILSRGRPDSNKTENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAGLQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASVHTLRQTSLAWLDQYCSLPALRPTVLNSLRQLGTSTSILTDPGRIPEQATRAVTEGTLGKPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	QVPRVAPSPDSDSDT CCCCCCCCCCCCCCC	31.44	23312004
23	Phosphorylation	RVAPSPDSDSDTDSE CCCCCCCCCCCCCCC	42.26	20363803
25	Phosphorylation	APSPDSDSDTDSEDP CCCCCCCCCCCCCCH	46.49	21082442
27	Phosphorylation	SPDSDSDTDSEDPSL CCCCCCCCCCCCHHH	45.43	20363803
29	Phosphorylation	DSDSDTDSEDPSLRR CCCCCCCCCCHHHHH	46.09	22798277
33	Phosphorylation	DTDSEDPSLRRSAGG CCCCCCHHHHHHHHH	46.99	23312004
37	Phosphorylation	EDPSLRRSAGGLLRS CCHHHHHHHHHHHHH	25.49	24275569
44	Phosphorylation	SAGGLLRSQVIHSGH HHHHHHHHEEEECCE	28.86	23312004
49	Phosphorylation	LRSQVIHSGHFMVSS HHHEEEECCEEEECC	23.88	23312004
55	Phosphorylation	HSGHFMVSSPHSDSL ECCEEEECCCCCCCC	26.77	28348404
56	Phosphorylation	SGHFMVSSPHSDSLP CCEEEECCCCCCCCC	18.41	28348404
59	Phosphorylation	FMVSSPHSDSLPRRR EEECCCCCCCCCCCC	32.07	23312004
61	Phosphorylation	VSSPHSDSLPRRRDQ ECCCCCCCCCCCCCC	43.20	23312004
71	Phosphorylation	RRRDQEGSVGPSDFG CCCCCCCCCCHHHCC	24.13	22798277
81	Phosphorylation	PSDFGPRSIDPTLTR HHHCCCCCCCHHHHH	34.18	22798277
103	Phosphorylation	AYSGKLVSPKWKNFK HHCCCCCCCCCCCCC	31.06	24719451
140	Phosphorylation	QYVKRRKSPVCGFVT HHHHHCCCCCCEEEC	22.28	21665952
147	Phosphorylation	SPVCGFVTPLQGPEA CCCCEEECCCCCCCC	18.93	28985074
171	Acetylation	VLEGNYWKRRIEVVM EEECCCHHHHHHHHH	22.80	19813591
196	Phosphorylation	KKRLRKPSREDDLLA HHHCCCCCCCCCCCC	51.87	25072903
361	Phosphorylation	SRLQARNSCPGPLDS CHHHCCCCCCCCCCH	19.01	23663014
368	Phosphorylation	SCPGPLDSSAFLSSD CCCCCCCHHHHHCCC	31.11	23312004
369	Phosphorylation	CPGPLDSSAFLSSDF CCCCCCHHHHHCCCC	23.78	23312004
373	Phosphorylation	LDSSAFLSSDFLLPE CCHHHHHCCCCCCCC	22.77	23312004
374	Phosphorylation	DSSAFLSSDFLLPED CHHHHHCCCCCCCCC	34.23	23312004
499	Phosphorylation	RGKPPAPSPRGQKAS CCCCCCCCCCCCCCC	29.36	23312004
556	Phosphorylation	TLLRSPGSPQETVPE EEECCCCCCCCCCCC	27.13	-
602	Phosphorylation	VPKAERLSPPAPSGS CCCHHHCCCCCCCCC	34.75	28102081
607	Phosphorylation	RLSPPAPSGSERRLS HCCCCCCCCCCCCCC	57.99	23186163
609	Phosphorylation	SPPAPSGSERRLSGD CCCCCCCCCCCCCCC	32.06	23312004
614	Phosphorylation	SGSERRLSGDLSSMP CCCCCCCCCCCCCCC	28.57	22617229
618	Phosphorylation	RRLSGDLSSMPGPGT CCCCCCCCCCCCCCE	29.36	28674151
619	Phosphorylation	RLSGDLSSMPGPGTL CCCCCCCCCCCCCEE	35.97	28857561
625	Phosphorylation	SSMPGPGTLSVRVSP CCCCCCCEEEEEECC	20.99	27251275
627	Phosphorylation	MPGPGTLSVRVSPPQ CCCCCEEEEEECCCC	14.02	27251275
631	Phosphorylation	GTLSVRVSPPQPILS CEEEEEECCCCCCCC	21.94	11230181
651 (in isoform 3)	Phosphorylation	-	50.14	11698644
651 (in isoform 4)	Phosphorylation	-	50.14	11698644
653	Phosphorylation	KTENRRITHISAEQK CCCCCCCCCCCHHHH	16.02	11698644
807	Phosphorylation	AWLDQYCSLPALRPT HHHHHHCCCHHHCHH	32.24	24719451
840	Phosphorylation	GRIPEQATRAVTEGT CCCCHHHHHHHHHCC	20.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
196	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
556	S	Phosphorylation	Kinase	AMPK	Q9Y478	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
556	S	Phosphorylation	Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MLXPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLX_HUMAN	MLX	physical	11230181
MLX_HUMAN	MLX	physical	20382893

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.