MLX_HUMAN - dbPTM
MLX_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MLX_HUMAN
UniProt AC Q9UH92
Protein Name Max-like protein X
Gene Name MLX
Organism Homo sapiens (Human).
Sequence Length 298
Subcellular Localization Isoform Alpha: Cytoplasm . Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Beta: Cytoplasm . Found predominantly in the cytoplasm (PubMed:10918583).
Isoform Gamma: Nucleus . Found predominantly in the nucleus (PubMed:10918
Protein Description Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation..
Protein Sequence MTEPGASPEDPWVKASPVGAHAGEGRAGRARARRGAGRRGASLLSPKSPTLSVPRGCREDSSHPACAKVEYAYSDNSLDPGLFVESTRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHKEKKKQEEEVSTLRKDVTALKIMKVNYEQIVKAHQDNPHEGEDQVSDQVKFNVFQGIMDSLFQSFNASISVASFQELSACVFSWIEEHCKPQTLREIVIGVLHQLKNQLY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTEPGASPE
------CCCCCCCCC		51.3823663014
7 (in isoform 2)Phosphorylation-34.4429507054
7Phosphorylation-MTEPGASPEDPWVK
-CCCCCCCCCCCCCC		34.4428188228
7 (in isoform 3)Phosphorylation-34.4429507054
17 (in isoform 2)Phosphorylation-33.1627732954
17 (in isoform 3)Phosphorylation-33.16-
19 (in isoform 2)Phosphorylation-18.2827732954
19 (in isoform 3)Phosphorylation-18.28-
20 (in isoform 2)Phosphorylation-6.9227732954
20 (in isoform 3)Phosphorylation-6.9224275569
23 (in isoform 2)Phosphorylation-28.2027732954
26MethylationGAHAGEGRAGRARAR
CCCCCCCHHHHHHHH		29.57115483567
29MethylationAGEGRAGRARARRGA
CCCCHHHHHHHHCCC		21.66115483575
31 (in isoform 2)Phosphorylation-27.5423090842
31MethylationEGRAGRARARRGAGR
CCHHHHHHHHCCCCC		27.54115483583
33 (in isoform 2)Phosphorylation-31.8223090842
38 (in isoform 2)Phosphorylation-33.0723090842
39UbiquitinationARRGAGRRGASLLSP
HHCCCCCCCCCCCCC		44.0829967540
42PhosphorylationGAGRRGASLLSPKSP
CCCCCCCCCCCCCCC		32.4430266825
45PhosphorylationRRGASLLSPKSPTLS
CCCCCCCCCCCCCCC		35.2630266825
48PhosphorylationASLLSPKSPTLSVPR
CCCCCCCCCCCCCCC		26.8825159151
50PhosphorylationLLSPKSPTLSVPRGC
CCCCCCCCCCCCCCC		38.4626434776
52PhosphorylationSPKSPTLSVPRGCRE
CCCCCCCCCCCCCCC		32.3324719451
56UbiquitinationPTLSVPRGCREDSSH
CCCCCCCCCCCCCCC		14.5729967540
71PhosphorylationPACAKVEYAYSDNSL
CCCEEEEEECCCCCC		17.5227732954
73PhosphorylationCAKVEYAYSDNSLDP
CEEEEEECCCCCCCC		18.6930576142
74PhosphorylationAKVEYAYSDNSLDPG
EEEEEECCCCCCCCC		23.3430576142
77PhosphorylationEYAYSDNSLDPGLFV
EEECCCCCCCCCCEE		38.8622496350
86UbiquitinationDPGLFVESTRKGSVV
CCCCEEEECCCCCCE		28.3621963094
87PhosphorylationPGLFVESTRKGSVVS
CCCEEEECCCCCCEE		23.93-
89UbiquitinationLFVESTRKGSVVSRA
CEEEECCCCCCEECC		56.4733845483
91PhosphorylationVESTRKGSVVSRANS
EEECCCCCCEECCCC		23.5228857561
94PhosphorylationTRKGSVVSRANSIGS
CCCCCCEECCCCCCC		24.4224719451
98PhosphorylationSVVSRANSIGSTSAS
CCEECCCCCCCCCCC		27.6025159151
101PhosphorylationSRANSIGSTSASSVP
ECCCCCCCCCCCCCC		19.9528450419
102PhosphorylationRANSIGSTSASSVPN
CCCCCCCCCCCCCCC		24.0928450419
103PhosphorylationANSIGSTSASSVPNT
CCCCCCCCCCCCCCC		28.0528450419
105UbiquitinationSIGSTSASSVPNTDD
CCCCCCCCCCCCCCC		31.4729967540
105PhosphorylationSIGSTSASSVPNTDD
CCCCCCCCCCCCCCC		31.4730576142
106PhosphorylationIGSTSASSVPNTDDE
CCCCCCCCCCCCCCC		41.1130576142
110PhosphorylationSASSVPNTDDEDSDY
CCCCCCCCCCCCCHH		38.4625159151
115PhosphorylationPNTDDEDSDYHQEAY
CCCCCCCCHHHHHHH		37.7128102081
116UbiquitinationNTDDEDSDYHQEAYK
CCCCCCCHHHHHHHH		58.2021963094
117PhosphorylationTDDEDSDYHQEAYKE
CCCCCCHHHHHHHHH		14.8923663014
119UbiquitinationDEDSDYHQEAYKESY
CCCCHHHHHHHHHHH		30.6833845483
122PhosphorylationSDYHQEAYKESYKDR
CHHHHHHHHHHHHHH		17.9723663014
125UbiquitinationHQEAYKESYKDRRRR
HHHHHHHHHHHHHHH		33.0733845483
126PhosphorylationQEAYKESYKDRRRRA
HHHHHHHHHHHHHHH		20.28-
135UbiquitinationDRRRRAHTQAEQKRR
HHHHHHHHHHHHHHH		28.6129967540
136UbiquitinationRRRRAHTQAEQKRRD
HHHHHHHHHHHHHHH		32.7921963094
136 (in isoform 2)Ubiquitination-32.7921906983
140UbiquitinationAHTQAEQKRRDAIKR
HHHHHHHHHHHHHHH		40.6921963094
143UbiquitinationQAEQKRRDAIKRGYD
HHHHHHHHHHHHCHH		57.5922817900
155UbiquitinationGYDDLQTIVPTCQQQ
CHHHHHHHCHHHCCC		1.9433845483
166 (in isoform 3)Ubiquitination-6.5921906983
166UbiquitinationCQQQDFSIGSQKLSK
HCCCCCCCCCHHHHH		6.5921963094
170UbiquitinationDFSIGSQKLSKAIVL
CCCCCCHHHHHHHHH		57.3221963094
173UbiquitinationIGSQKLSKAIVLQKT
CCCHHHHHHHHHHHH		53.2022817900
179UbiquitinationSKAIVLQKTIDYIQF
HHHHHHHHHHHHHHH		43.20-
180PhosphorylationKAIVLQKTIDYIQFL
HHHHHHHHHHHHHHH		13.2029978859
183PhosphorylationVLQKTIDYIQFLHKE
HHHHHHHHHHHHCHH		7.8629978859
189UbiquitinationDYIQFLHKEKKKQEE
HHHHHHCHHHHHHHH		73.6729967540
190UbiquitinationYIQFLHKEKKKQEEE
HHHHHCHHHHHHHHH		60.4021963094
192UbiquitinationQFLHKEKKKQEEEVS
HHHCHHHHHHHHHHH		61.86-
193UbiquitinationFLHKEKKKQEEEVST
HHCHHHHHHHHHHHH		74.20-
206PhosphorylationSTLRKDVTALKIMKV
HHHHHHHHHHHEEEC		36.08-
209UbiquitinationRKDVTALKIMKVNYE
HHHHHHHHEEECCHH		37.9933845483
212UbiquitinationVTALKIMKVNYEQIV
HHHHHEEECCHHHHH		30.70-
215PhosphorylationLKIMKVNYEQIVKAH
HHEEECCHHHHHHHH		16.5227642862
220UbiquitinationVNYEQIVKAHQDNPH
CCHHHHHHHHCCCCC		41.6021963094
220 (in isoform 1)Ubiquitination-41.6021906983
294UbiquitinationIGVLHQLKNQLY---
HHHHHHHHHHCC---		35.76-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MLX_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MLX_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MLX_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GBRL2_HUMANGABARAPL2physical
16189514
MAD4_HUMANMXD4physical
11073985
MLXIP_HUMANMLXIPphysical
12446771
MLXPL_HUMANMLXIPLphysical
11230181
MLX_HUMANMLXphysical
11230181
MLX_HUMANMLXphysical
10918583
MAD1_HUMANMXD1physical
10918583
MNT_HUMANMNTphysical
10918583
A4_HUMANAPPphysical
21832049
S30BP_HUMANSAP30BPphysical
18255255
ID3_HUMANID3physical
18255255
RBM39_HUMANRBM39physical
25416956
GBRL2_HUMANGABARAPL2physical
25416956
ZBT32_HUMANZBTB32physical
25416956
MLXIP_HUMANMLXIPphysical
28514442
MLXPL_HUMANMLXIPLphysical
28514442
CSPG5_HUMANCSPG5physical
28514442
CSK22_HUMANCSNK2A2physical
28514442
BACH1_HUMANBACH1physical
28514442
CSK21_HUMANCSNK2A1physical
28514442
SNX1_HUMANSNX1physical
28514442
AMPD2_HUMANAMPD2physical
28514442
MGAP_HUMANMGAphysical
28514442
SNX5_HUMANSNX5physical
28514442
CSK2B_HUMANCSNK2Bphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MLX_HUMAN

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Related Literatures of Post-Translational Modification

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