| UniProt ID | MAD4_HUMAN | |
|---|---|---|
| UniProt AC | Q14582 | |
| Protein Name | Max dimerization protein 4 | |
| Gene Name | MXD4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 209 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).. | |
| Protein Sequence | MELNSLLILLEAAEYLERRDREAEHGYASVLPFDGDFAREKTKAAGLVRKAPNNRSSHNELEKHRRAKLRLYLEQLKQLVPLGPDSTRHTTLSLLKRAKVHIKKLEEQDRRALSIKEQLQQEHRFLKRRLEQLSVQSVERVRTDSTGSAVSTDDSEQEVDIEGMEFGPGELDSVGSSSDADDHYSLQSGTGGDSGFGPHCRRLGRPALS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MELNSLLILLEA ---CCHHHHHHHHHH | 36.86 | 29083192 | |
| 27 | Phosphorylation | DREAEHGYASVLPFD HHHHHHCCCCCCCCC | 9.52 | 27642862 | |
| 77 | Ubiquitination | RLYLEQLKQLVPLGP HHHHHHHHHHCCCCC | 41.08 | 21963094 | |
| 93 | Phosphorylation | STRHTTLSLLKRAKV CCHHHHHHHHHHHHH | 29.57 | 20860994 | |
| 96 | Ubiquitination | HTTLSLLKRAKVHIK HHHHHHHHHHHHHHH | 56.45 | 29967540 | |
| 116 | Ubiquitination | DRRALSIKEQLQQEH HHHHHHHHHHHHHHH | 35.71 | 21963094 | |
| 131 | Ubiquitination | RFLKRRLEQLSVQSV HHHHHHHHHHCCCEE | 47.89 | 21963094 | |
| 170 | Ubiquitination | GMEFGPGELDSVGSS CCEECCCCCCCCCCC | 53.16 | 21963094 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MAD4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MAD4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MAD4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MLX_HUMAN | MLX | physical | 10593926 | |
| MAX_HUMAN | MAX | physical | 10593926 | |
| TCP1L_HUMAN | TCP10L | physical | 21988832 | |
| CU077_HUMAN | TCP10L | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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