TCP1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCP1L_HUMAN
• UniProt AC: Q8TDR4
• Protein Name: T-complex protein 10A homolog 2
• Gene Name: TCP10L
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells..
• Protein Sequence: MLAGQLEARDPKEGTHPEDPCPGAGAVMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSNNSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	QELGRQKSLWADVHG HHHHCCCCHHHHHHH	22.32	23909892
110	Phosphorylation	ARKKSAASPHAGQES HHHHHCCCCCCCCHH	19.55	-
149	Phosphorylation	YAGHKNQSATLLGQR HCCCCCCCCEECCCC	32.39	29978859
151	Phosphorylation	GHKNQSATLLGQRSS CCCCCCCEECCCCCC	27.97	29978859
157	Phosphorylation	ATLLGQRSSSNNSAP CEECCCCCCCCCCCC	30.17	29978859
158	Phosphorylation	TLLGQRSSSNNSAPP EECCCCCCCCCCCCC	38.99	29978859
159	Phosphorylation	LLGQRSSSNNSAPPK ECCCCCCCCCCCCCC	41.08	23532336
162	Phosphorylation	QRSSSNNSAPPKPMS CCCCCCCCCCCCCCC	46.53	23532336
200	Phosphorylation	RRQDRRATPTGRPTP HHHHHCCCCCCCCCC	21.41	22210691
202	Phosphorylation	QDRRATPTGRPTPCA HHHCCCCCCCCCCHH	41.28	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCP1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCP1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCP1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAD4_HUMAN	MXD4	physical	15469726
A4_HUMAN	APP	physical	21832049
TNNC1_HUMAN	TNNC1	physical	21988832
GRAP1_HUMAN	GRIPAP1	physical	28514442
PPR21_HUMAN	PPP1R21	physical	28514442
TBCK_HUMAN	TBCK	physical	28514442
KI20B_HUMAN	KIF20B	physical	28514442
QORL1_HUMAN	CRYZL1	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
SH3K1_HUMAN	SH3KBP1	physical	28514442
FBX28_HUMAN	FBXO28	physical	28514442
PICK1_HUMAN	PICK1	physical	28514442
NIN_HUMAN	NIN	physical	28514442
UBP4_HUMAN	USP4	physical	28514442
AF10_HUMAN	MLLT10	physical	28514442
BRE1B_HUMAN	RNF40	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
FYCO1_HUMAN	FYCO1	physical	28514442
BICD2_HUMAN	BICD2	physical	28514442
CD2AP_HUMAN	CD2AP	physical	28514442
PCNT_HUMAN	PCNT	physical	28514442
GCC2_HUMAN	GCC2	physical	28514442
NUMA1_HUMAN	NUMA1	physical	28514442
CL004_HUMAN	C12orf4	physical	28514442
TCP2L_HUMAN	TCP10L2	physical	28514442
HOME1_HUMAN	HOMER1	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
CCDC6_HUMAN	CCDC6	physical	28514442
SNAPN_HUMAN	SNAPIN	physical	28514442
KIF2C_HUMAN	KIF2C	physical	28514442
KLH23_HUMAN	KLHL23	physical	28514442
CI016_HUMAN	C9orf16	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442
FBX11_HUMAN	FBXO11	physical	28514442
H1BP3_HUMAN	HS1BP3	physical	28514442
NDE1_HUMAN	NDE1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.