BCAP_HUMAN - dbPTM
BCAP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCAP_HUMAN
UniProt AC Q6ZUJ8
Protein Name Phosphoinositide 3-kinase adapter protein 1
Gene Name PIK3AP1
Organism Homo sapiens (Human).
Sequence Length 805
Subcellular Localization Cytoplasm. Cell membrane
Peripheral membrane protein.
Protein Description Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL..
Protein Sequence MAASGVPRGCDILIVYSPDAEEWCQYLQTLFLSSRQVRSQKILTHRLGPEASFSAEDLSLFLSTRCVVVLLSAELVQHFHKPALLPLLQRAFHPPHRVVRLLCGVRDSEEFLDFFPDWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPGNLMVVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMTNQRDEELPTLLHFAAKYGLKNLTALLLTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKSHIKEELMHGEEADAVYESMAHLSTDLLMKCSLNPGCDEDLYESMAAFVPAATEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLEGNSMGMTNLERDQCHLGQEEDVYHTVDDDEAFSVDLASRPPVPVPRPETTAPGAHQLPDNEPYIFKVFAEKSQERPGNFYVSSESIRKGPPVRPWRDRPQSSIYDPFAGMKTPGQRQLITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRDSITRRQREKQKSGKQTDLEITVPIRHSQHLPAKVEFGVYESGPRKSVIPPRTELRRGDWKTDSTSSTASSTSNRSSTRSLLSVSSGMEGDNEDNEVPEVTRSRSPGPPQVDGTPTMSLERPPRVPPRAASQRPPTRETFHPPPPVPPRGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56 (in isoform 3)Phosphorylation-59.2825072903
57 (in isoform 3)Phosphorylation-41.0725072903
58 (in isoform 3)Phosphorylation-3.4525072903
65 (in isoform 3)Phosphorylation-14.0925072903
66 (in isoform 3)Phosphorylation-2.4925072903
67 (in isoform 3)Phosphorylation-2.7725072903
76 (in isoform 3)Phosphorylation-2.9025072903
86 (in isoform 3)Ubiquitination-31.6921890473
133PhosphorylationCDDEPETYVAAVKKA
CCCCCHHHHHHHHHH		6.0922817900
142PhosphorylationAAVKKAISEDSGCDS
HHHHHHHHCCCCCCC		39.9628450419
145PhosphorylationKKAISEDSGCDSVTD
HHHHHCCCCCCCCCC		36.9528450419
149PhosphorylationSEDSGCDSVTDTEPE
HCCCCCCCCCCCCCC		30.8723401153
151PhosphorylationDSGCDSVTDTEPEDE
CCCCCCCCCCCCCCC		40.9523401153
153PhosphorylationGCDSVTDTEPEDEKV
CCCCCCCCCCCCCCE		44.0430108239
162PhosphorylationPEDEKVVSYSKQQNL
CCCCCEECCCCCCCC		27.0321552520
163PhosphorylationEDEKVVSYSKQQNLP
CCCCEECCCCCCCCC		14.3123312004
164PhosphorylationDEKVVSYSKQQNLPT
CCCEECCCCCCCCCC		19.2427486199
171PhosphorylationSKQQNLPTVTSPGNL
CCCCCCCCCCCCCCE		39.3128450419
173PhosphorylationQQNLPTVTSPGNLMV
CCCCCCCCCCCCEEE		31.5128450419
174PhosphorylationQNLPTVTSPGNLMVV
CCCCCCCCCCCEEEE		26.8628188228
230PhosphorylationEAKVENEYTISVKAP
EEEEEEEEEEEEECC		22.4326074081
231PhosphorylationAKVENEYTISVKAPN
EEEEEEEEEEEECCC		10.7026074081
233PhosphorylationVENEYTISVKAPNLS
EEEEEEEEEECCCCC		15.1226074081
240PhosphorylationSVKAPNLSSGNVSLK
EEECCCCCCCCEEEE		42.7226074081
241PhosphorylationVKAPNLSSGNVSLKI
EECCCCCCCCEEEEE		37.2426074081
245PhosphorylationNLSSGNVSLKIYSGD
CCCCCCEEEEEECCC		28.1326074081
249PhosphorylationGNVSLKIYSGDLVVC
CCEEEEEECCCEEEE		12.6726074081
250PhosphorylationNVSLKIYSGDLVVCE
CEEEEEECCCEEEEE		29.3326074081
263PhosphorylationCETVISYYTDMEEIG
EEEEHHHCCCHHHHH		6.89-
309 (in isoform 2)Ubiquitination-4.1621890473
349UbiquitinationFAAKYGLKNLTALLL
HHHHHCCCHHHHHHH		45.61-
394PhosphorylationLRQFIDEYVETVDML
HHHHHHHHHHHHHHH		10.3922468782
419PhosphorylationGEEADAVYESMAHLS
CHHHHHHHHHHHHHC		12.1928176486
421PhosphorylationEADAVYESMAHLSTD
HHHHHHHHHHHHCHH		12.0028176486
444PhosphorylationPGCDEDLYESMAAFV
CCCCHHHHHHHHHHC		20.48-
459PhosphorylationPAATEDLYVEMLQAS
CCCCHHHHHHHHHHH		13.49-
483PhosphorylationFSRATKDSMIRKFLE
CCHHCHHHHHHHHHC		20.0528857561
487UbiquitinationTKDSMIRKFLEGNSM
CHHHHHHHHHCCCCC		43.2921890473
487 (in isoform 1)Ubiquitination-43.2921890473
513PhosphorylationLGQEEDVYHTVDDDE
CCCCCCCEEECCCCC		12.2322817900
553PhosphorylationQLPDNEPYIFKVFAE
CCCCCCCCEEEEEEC		16.8922817900
562PhosphorylationFKVFAEKSQERPGNF
EEEEECCCCCCCCCE		28.8728857561
570PhosphorylationQERPGNFYVSSESIR
CCCCCCEEECHHHHC		11.9228674151
572PhosphorylationRPGNFYVSSESIRKG
CCCCEEECHHHHCCC		19.6028450419
573PhosphorylationPGNFYVSSESIRKGP
CCCEEECHHHHCCCC		25.8928450419
575PhosphorylationNFYVSSESIRKGPPV
CEEECHHHHCCCCCC		29.6423401153
591PhosphorylationPWRDRPQSSIYDPFA
CCCCCCCCCCCCCCC		22.7628450419
592PhosphorylationWRDRPQSSIYDPFAG
CCCCCCCCCCCCCCC		21.6628450419
594PhosphorylationDRPQSSIYDPFAGMK
CCCCCCCCCCCCCCC		21.3622817900
601UbiquitinationYDPFAGMKTPGQRQL
CCCCCCCCCCCCCEE		51.13-
640PhosphorylationQLNQKKRSESFRFQQ
HCCCCHHCHHHHHHH		46.6128450419
642PhosphorylationNQKKRSESFRFQQEN
CCCHHCHHHHHHHHH		23.9823401153
656PhosphorylationNLKRLRDSITRRQRE
HHHHHHHHHHHHHHH		21.3023401153
658PhosphorylationKRLRDSITRRQREKQ
HHHHHHHHHHHHHHH		24.6130266825
676PhosphorylationKQTDLEITVPIRHSQ
CCCCCEEEEECCCCC		15.7424043423
682PhosphorylationITVPIRHSQHLPAKV
EEEECCCCCCCCEEE		14.9428857561
694PhosphorylationAKVEFGVYESGPRKS
EEEEEEEECCCCCCC		12.5419605366
696PhosphorylationVEFGVYESGPRKSVI
EEEEEECCCCCCCCC		36.0929978859
701PhosphorylationYESGPRKSVIPPRTE
ECCCCCCCCCCCCCC		26.9328857561
716PhosphorylationLRRGDWKTDSTSSTA
CCCCCCCCCCCCCCC		30.8130576142
718PhosphorylationRGDWKTDSTSSTASS
CCCCCCCCCCCCCCC		35.1128450419
719PhosphorylationGDWKTDSTSSTASST
CCCCCCCCCCCCCCC		29.5225072903
720PhosphorylationDWKTDSTSSTASSTS
CCCCCCCCCCCCCCC		29.6428450419
721PhosphorylationWKTDSTSSTASSTSN
CCCCCCCCCCCCCCC		28.2528450419
722PhosphorylationKTDSTSSTASSTSNR
CCCCCCCCCCCCCCC		30.2628450419
724PhosphorylationDSTSSTASSTSNRSS
CCCCCCCCCCCCCCC		33.9528450419
725PhosphorylationSTSSTASSTSNRSST
CCCCCCCCCCCCCCC		33.1328450419
726PhosphorylationTSSTASSTSNRSSTR
CCCCCCCCCCCCCCC		27.7628450419
727PhosphorylationSSTASSTSNRSSTRS
CCCCCCCCCCCCCCE		31.9930576142
730PhosphorylationASSTSNRSSTRSLLS
CCCCCCCCCCCEEEE		40.0728450419
731PhosphorylationSSTSNRSSTRSLLSV
CCCCCCCCCCEEEEC		25.3028450419
732PhosphorylationSTSNRSSTRSLLSVS
CCCCCCCCCEEEECC		26.0628450419
734PhosphorylationSNRSSTRSLLSVSSG
CCCCCCCEEEECCCC		33.4824667141
737PhosphorylationSSTRSLLSVSSGMEG
CCCCEEEECCCCCCC		25.8328450419
739PhosphorylationTRSLLSVSSGMEGDN
CCEEEECCCCCCCCC		20.1424719451
740PhosphorylationRSLLSVSSGMEGDNE
CEEEECCCCCCCCCC		39.7528450419
757PhosphorylationEVPEVTRSRSPGPPQ
CCCCCCCCCCCCCCC		27.9523401153
759PhosphorylationPEVTRSRSPGPPQVD
CCCCCCCCCCCCCCC		35.1423401153
768PhosphorylationGPPQVDGTPTMSLER
CCCCCCCCCCCCCCC		15.8929759185
770PhosphorylationPQVDGTPTMSLERPP
CCCCCCCCCCCCCCC		21.1630301811
772PhosphorylationVDGTPTMSLERPPRV
CCCCCCCCCCCCCCC		29.5630301811
793PhosphorylationQRPPTRETFHPPPPV
CCCCCCCCCCCCCCC		24.7726657352
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
419YPhosphorylationKinaseSYKP43405
Uniprot
444YPhosphorylationKinaseSYKP43405
Uniprot
459YPhosphorylationKinaseSYKP43405
Uniprot
513YPhosphorylationKinaseABLP00519
PSP
513YPhosphorylationKinaseABL-FAMILY-GPS
553YPhosphorylationKinaseABLP00519
PSP
553YPhosphorylationKinaseABL-FAMILY-GPS
570YPhosphorylationKinaseABLP00519
PSP
570YPhosphorylationKinaseABL-FAMILY-GPS
594YPhosphorylationKinaseABLP00519
PSP
594YPhosphorylationKinaseABL-FAMILY-GPS
694YPhosphorylationKinaseABLP00519
PSP
694YPhosphorylationKinaseABL-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCAP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCAP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NCK2_HUMANNCK2physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCAP_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-694, AND MASSSPECTROMETRY.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-694, AND MASSSPECTROMETRY.
"Identification of B cell adaptor for PI3-kinase (BCAP) as an Ablinteractor 1-regulated substrate of Abl kinases.";
Maruoka M., Suzuki J., Kawata S., Yoshida K., Hirao N., Sato S.,Goff S.P., Takeya T., Tani K., Shishido T.;
FEBS Lett. 579:2986-2990(2005).
Cited for: FUNCTION, INTERACTION WITH ABI1, AND PHOSPHORYLATION AT TYR-513;TYR-553; TYR-570; TYR-594 AND TYR-694.

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