PLCG1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCG1_RAT
• UniProt AC: P10686
• Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
• Gene Name: Plcg1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1290
• Subcellular Localization: Cell projection, lamellipodium. Cell projection, ruffle. Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment..
• Protein Description: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity)..
• Protein Sequence: MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDFEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNTLRTGERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGVGTPCA ------CCCCCCCCC	32.46	-
175	Acetylation	REDRISAKDLKNMLS HHCCCCHHHHHHHHH	57.72	22902405
379	Phosphorylation	PDGMPVIYHGHTLTT CCCCEEEEECCEEEE	11.28	-
481	Phosphorylation	EVPTSVMYSENDISN CCCCCEECCCCCCCH	15.63	-
506	Phosphorylation	DPVNHEWYPHYFVLT CCCCCCCCCEEEEEE	4.16	-
509	Phosphorylation	NHEWYPHYFVLTSSK CCCCCCEEEEEECCE	7.29	20164676
513	Phosphorylation	YPHYFVLTSSKIYYS CCEEEEEECCEEEEE	26.17	22673903
514	Phosphorylation	PHYFVLTSSKIYYSE CEEEEEECCEEEEEC	26.02	22673903
515	Phosphorylation	HYFVLTSSKIYYSEE EEEEEECCEEEEECC	20.17	22673903
518	Phosphorylation	VLTSSKIYYSEETSS EEECCEEEEECCCCC	12.50	23984901
519	Phosphorylation	LTSSKIYYSEETSSD EECCEEEEECCCCCC	17.06	23984901
520	Phosphorylation	TSSKIYYSEETSSDQ ECCEEEEECCCCCCC	16.40	23984901
523	Phosphorylation	KIYYSEETSSDQGNE EEEEECCCCCCCCCC	29.49	23984901
524	Phosphorylation	IYYSEETSSDQGNED EEEECCCCCCCCCCC	34.89	23984901
525	Phosphorylation	YYSEETSSDQGNEDE EEECCCCCCCCCCCC	41.18	27097102
582	Phosphorylation	ETGAPDGSFLVRESE HHCCCCCCEEEEECC	23.84	27097102
766	Phosphorylation	EALEKIGTAEPDYGA HHHHHHCCCCCCCCC	31.18	30181290
771	Phosphorylation	IGTAEPDYGALYEGR HCCCCCCCCCCCCCC	18.27	27097102
775	Phosphorylation	EPDYGALYEGRNPGF CCCCCCCCCCCCCCC	18.79	8106527
783	Phosphorylation	EGRNPGFYVEANPMP CCCCCCCEEECCCCC	11.86	27097102
977	Phosphorylation	IGTERACYRDMSSFP HCCCCHHCCCHHHCC	14.52	-
1221	Phosphorylation	AKENGDLSPFSGTSL CCCCCCCCCCCCCCH	28.74	27097102
1224	Phosphorylation	NGDLSPFSGTSLRER CCCCCCCCCCCHHHH	44.54	27097102
1226	Phosphorylation	DLSPFSGTSLRERAS CCCCCCCCCHHHHHC	24.32	23984901
1227	Phosphorylation	LSPFSGTSLRERASD CCCCCCCCHHHHHCC	29.02	23984901
1233	Phosphorylation	TSLRERASDASSQLF CCHHHHHCCCCCCCE	39.67	28432305
1236	Phosphorylation	RERASDASSQLFHVR HHHHCCCCCCCEEEE	24.49	28432305
1237	Phosphorylation	ERASDASSQLFHVRA HHHCCCCCCCEEEEE	32.40	29779826
1248	Phosphorylation	HVRAREGSFEARYQQ EEEECCCCCEEECCC	18.37	29779826
1253	Phosphorylation	EGSFEARYQQPFEDF CCCCEEECCCCHHHC	20.67	27097102
1263	Phosphorylation	PFEDFRISQEHLADH CHHHCCCCHHHHHHH	25.84	27097102
1273	Phosphorylation	HLADHFDSRERRAPR HHHHHCCCCCCCCCC	34.79	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
771	Y	Phosphorylation	Kinase	SYK	Q64725	Uniprot
783	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
783	Y	Phosphorylation	Kinase	SYK	Q64725	Uniprot
783	Y	Phosphorylation	Kinase	NTRK2	Q63604	GPS
783	Y	Phosphorylation	Kinase	SRC	P12931	PSP
783	Y	Phosphorylation	Kinase	ZAP70	P43403	PSP
783	Y	Phosphorylation	Kinase	ITK	-	Uniprot
783	Y	Phosphorylation	Kinase	TXK	-	Uniprot
1253	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
1253	Y	Phosphorylation	Kinase	NTRK2	Q63604	GPS
1253	Y	Phosphorylation	Kinase	SRC	P12931	PSP
1253	Y	Phosphorylation	Kinase	ZAP70	P43403	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Cblb	Q8K4S7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCG1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCG1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP180_RAT	Snap91	physical	11779129
GRB2_RAT	Grb2	physical	16038803

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.