KRT36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KRT36_HUMAN
• UniProt AC: O76013
• Protein Name: Keratin, type I cuticular Ha6
• Gene Name: KRT36
• Organism: Homo sapiens (Human).
• Sequence Length: 467
• Protein Sequence: MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSARSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALEIELQAQHSMRNSLESTLAETEARYSSQLAQMQCLISNVEAQLSEIRCDLERQNQEYQVLLDVKARLEGEIATYRHLLEGEDCKLPPQPCATACKPVIRVPSVPPVPCVPSVPCTPAPQVGTQIRTITEEIRDGKVISSREHVQSRPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	TKYETELSLRQLVEA HHHHHHCHHHHHHHH	18.44	24719451
315	Phosphorylation	EIIELRRTVNALEIE HHHHHHHHHHHHHHH	16.21	20068231
328	Phosphorylation	IELQAQHSMRNSLES HHHHHHHHHHHHHHH	13.83	22817900
335	Phosphorylation	SMRNSLESTLAETEA HHHHHHHHHHHHHHH	33.73	-
336	Phosphorylation	MRNSLESTLAETEAR HHHHHHHHHHHHHHH	22.17	-
340	Phosphorylation	LESTLAETEARYSSQ HHHHHHHHHHHHHHH	29.36	-
363	Phosphorylation	SNVEAQLSEIRCDLE HHHHHHHHHHCCCHH	20.92	24719451
458	Phosphorylation	RDGKVISSREHVQSR HCCCEECCCCCHHCC	30.48	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KRT36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KRT36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-315 AND SER-328, ANDMASS SPECTROMETRY.
PubMed: 17081983