LY66F_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LY66F_HUMAN
• UniProt AC: Q5SQ64
• Protein Name: Lymphocyte antigen 6 complex locus protein G6f
• Gene Name: LY6G6F
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: May play a role in the downstream signal transduction pathways involving GRB2 and GRB7..
• Protein Sequence: MAVLFLLLFLCGTPQAADNMQAIYVALGEAVELPCPSPPTLHGDEHLSWFCSPAAGSFTTLVAQVQVGRPAPDPGKPGRESRLRLLGNYSLWLEGSKEEDAGRYWCAVLGQHHNYQNWRVYDVLVLKGSQLSARAADGSPCNVLLCSVVPSRRMDSVTWQEGKGPVRGRVQSFWGSEAALLLVCPGEGLSEPRSRRPRIIRCLMTHNKGVSFSLAASIDASPALCAPSTGWDMPWILMLLLTMGQGVVILALSIVLWRQRVRGAPGRDASIPQFKPEIQVYENIHLARLGPPAHKPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	N-linked_Glycosylation	SRLRLLGNYSLWLEG HHHHHEEEEEEEEEC	24.16	16263699
270	Phosphorylation	GAPGRDASIPQFKPE CCCCCCCCCCCCCCC	38.81	27535140
281	Phosphorylation	FKPEIQVYENIHLAR CCCCEEEECCEECCC	6.20	12852788

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LY66F_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LY66F_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LY66F_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LY66F_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach.";
Lewandrowski U., Moebius J., Walter U., Sickmann A.;
Mol. Cell. Proteomics 5:226-233(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88, AND MASS SPECTROMETRY.
PubMed: 16263699

Phosphorylation

"Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f,a novel member of the immunoglobulin superfamily encoded in the MHC.";
De Vet E.C.J.M., Aguado B., Campbell R.D.;
Biochem. J. 375:207-213(2003).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH GRB2 AND GRB7,SUBCELLULAR LOCATION, GLYCOSYLATION, PHOSPHORYLATION AT TYR-281, ANDMUTAGENESIS OF TYR-281.
PubMed: 12852788